1.1.1.30 (R)-2-hydroxybutanoate + NAD+ isoenzyme from heavy mitochondria and isoenzyme from light mitochondria show no significant difference in activity Jaculus orientalis acetoacetate + NADH - ? 383475 1.1.1.30 (R)-3-hydroxybutanoate + 3-acetylpyridine adenine dinucleotide - Bos taurus acetoacetate + 3-acetylpyridine adenine dinucleotideH2 - r 188035 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Cavia porcellus acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Paracoccus denitrificans acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Homo sapiens acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Rattus norvegicus acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Bos taurus acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Cereibacter sphaeroides acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Pseudomonas putida acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Mycolicibacterium phlei acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Bacillus cereus acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Paucimonas lemoignei acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Staphylococcus xylosus acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Zoogloea ramigera I-16-M acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Jaculus orientalis acetoacetate + NADH - ? 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Jaculus orientalis acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Pseudomonas fragi acetoacetate + NADH - ? 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Alcaligenes faecalis acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ model of the binding mode of the substrate D-3-hydroxybutyrate, Gln193 is the only residue of the substrate-binding loop that interacts directly with the substrate, NAD+ binding increases the flexibility of the substrate-binding loop and shifts the equilibrium between the open and closed forms towards the closed form, overview Pseudomonas putida acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Bacillus cereus T acetoacetate + NADH - r 188032 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Paracoccus denitrificans acetoacetate + NADH + H+ - ? 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Alcaligenes faecalis acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Homo sapiens acetoacetate + NADH + H+ - ? 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Rattus norvegicus acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Bos taurus acetoacetate + NADH + H+ - ? 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Bos taurus acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Mycolicibacterium phlei acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Bacillus cereus acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Staphylococcus xylosus acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Zoogloea ramigera I-16-M acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Pseudomonas putida acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Ralstonia pickettii acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Legionella pneumophila subsp. pneumophila acetoacetate + NADH + H+ - ? 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Danio rerio acetoacetate + NADH + H+ - ? 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Bacillus cereus T acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Paracoccus denitrificans ATCC 17741 acetoacetate + NADH + H+ - ? 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Ralstonia pickettii T1 acetoacetate + NADH + H+ - r 383477 1.1.1.30 (R)-3-hydroxybutanoate + NAD+ - Legionella pneumophila subsp. pneumophila DSM 7513 acetoacetate + NADH + H+ - ? 383477 1.1.1.30 (R)-3-hydroxybutanoate + NADH + H+ - Cupriavidus necator acetoacetate + NAD+ - r 394975 1.1.1.30 (R)-3-hydroxybutanoate + NADH + H+ the enzyme is involved in poly(3-hydroxybutyrate) biosynthesis together with acetoacetyl-CoA thiolase and PHB synthase, pathway overview, intracellular concentrations of key metabolites, i.e. CoA, acetyl-CoA, 3HB-CoA, NAD+/NADH, determine whether a cell accumulates or degrades PHB Cupriavidus necator acetoacetate + NAD+ - r 394975 1.1.1.30 (R)-3-hydroxybutanoate + NADP+ activity with NADP+ is 2% of the activity with NAD+ Pseudomonas fragi acetoacetate + NADPH - ? 383478 1.1.1.30 (R)-3-hydroxybutyrate + NAD+ - Camelus dromedarius acetoacetate + NADH + H+ - r 370745 1.1.1.30 (R)-3-hydroxybutyrate + NAD+ - Jaculus orientalis acetoacetate + NADH + H+ - r 370745 1.1.1.30 (R)-3-hydroxybutyrate + NAD+ - Acidovorax sp. acetoacetate + NADH + H+ - r 370745 1.1.1.30 (R)-3-hydroxybutyrate + NAD+ during hibernation, the enzyme is responsible for bioconvertion of high amounts of ketone bodies, i.e. acetoacetate and (R)-3-hydroxybutyrate, in the liver for usage as energetic fuel Jaculus orientalis acetoacetate + NADH + H+ - r 370745 1.1.1.30 (R)-3-hydroxybutyrate + NAD+ strain SA1 can degrade poly((R)-3-hydroxybutyrate), i.e. PHB Acidovorax sp. acetoacetate + NADH + H+ - r 370745 1.1.1.30 2-hydroxypropansulfonate + NAD+ - Paucimonas lemoignei acetonylsulfonate + NADH - r 188034 1.1.1.30 2-methyl-3-hydroxybutyrate + NAD+ - Paucimonas lemoignei 2-methylacetoacetate + NADH - r 188033 1.1.1.30 3-hydroxyvalerate + NAD+ - Paracoccus denitrificans 3-oxovalerate + NADH + H+ - ? 436876 1.1.1.30 3-hydroxyvalerate + NAD+ - Paracoccus denitrificans ATCC 17741 3-oxovalerate + NADH + H+ - ? 436876 1.1.1.30 4-hydroxybutanoate + NAD+ isoenzyme from heavy mitochondria shows 40% lower activity than enzyme fromlight mitochondria Jaculus orientalis acetoacetate + NADH - ? 383900 1.1.1.30 acetoacetate + NADH + H+ - Alcaligenes faecalis (R)-3-hydroxybutanoate + NAD+ - ? 436283 1.1.1.30 D-3-hydroxybutyrate + NAD+ - Pseudomonas fragi acetoacetate + NADH + H+ - r 404762 1.1.1.30 D-3-hydroxybutyrate + NAD+ BDH1 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate Ralstonia pickettii acetoacetate + NADH + H+ - r 404762 1.1.1.30 D-3-hydroxybutyrate + NAD+ BDH2 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate Ralstonia pickettii acetoacetate + NADH + H+ - r 404762 1.1.1.30 D-3-hydroxybutyrate + NAD+ BDH3 is specialized to utilize 3-hydroxybutyrate Ralstonia pickettii acetoacetate + NADH + H+ - r 404762 1.1.1.30 D-3-hydroxybutyrate + NAD+ the reversible reactions occur by shuttle movements of a hydrogen negative ion from the C3 atom of the substrate to the C4 atom of NAD+ and from the C4 atom of NADH to the C3 atom of the product. The reaction may be further coupled to the withdrawal of a proton from the hydroxyl group of the substrate by the ionized Tyr155 residue Alcaligenes faecalis acetoacetate + NADH + H+ - r 404762 1.1.1.30 D-3-hydroxybutyrate + NAD+ BDH3 is specialized to utilize 3-hydroxybutyrate Ralstonia pickettii T1 acetoacetate + NADH + H+ - r 404762 1.1.1.30 D-3-hydroxybutyrate + NAD+ BDH2 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate Ralstonia pickettii T1 acetoacetate + NADH + H+ - r 404762 1.1.1.30 D-3-hydroxybutyrate + NAD+ BDH1 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate Ralstonia pickettii T1 acetoacetate + NADH + H+ - r 404762 1.1.1.30 L-threonine + NAD+ - Pseudomonas fragi ? - ? 385067 1.1.1.30 levulinic acid + NADH + H+ only the recombinant wild type enzyme with N-terminal His-tag shows activity with levulinic acid Alcaligenes faecalis 4-hydroxyvaleric acid + NAD+ - ? 437671 1.1.1.30 levulinic acid + NADH + H+ the wild type enzyme shows low activity with levulinic acid, while it's a good substrate for mutant enzyme H144L/W187F Alcaligenes faecalis 4-hydroxyvaleric acid + NAD+ - ? 437671 1.1.1.30 additional information enzyme activity is differently regulated in liver and brain at euthermic, prehibernating,and hibernating state Jaculus orientalis ? - ? 89 1.1.1.30 additional information a ketone body converting enzyme in mitochondria in liver jerboa, enzyme expression, activity and metabolism at different physiological states, overview Jaculus orientalis ? - ? 89 1.1.1.30 additional information no activity of the wild-type enzyme with levulinic acid, enzyme mutant H144L/W187F is active with levulinic acid producing 4-hydroxyvaleric acid Alcaligenes faecalis ? - ? 89 1.1.1.30 poly-3-hydroxybutyrate + NAD+ - Ralstonia pickettii acetoacetate + NADH + H+ - r 406417 1.1.1.30 poly-3-hydroxybutyrate + NAD+ - Ralstonia pickettii T1 acetoacetate + NADH + H+ - r 406417