1.1.1.188 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - Homo sapiens (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ - ? 438017 1.1.1.188 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - Leishmania major (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ - ? 438017 1.1.1.188 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - Trypanosoma cruzi (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ - ? 438017 1.1.1.188 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - Trypanosoma cruzi CL Brener (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ - ? 438017 1.1.1.188 (5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+ - Homo sapiens (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ - ? 438018 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH - Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257133 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH - Rattus norvegicus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257133 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH - Bos taurus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257133 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH - Oryctolagus cuniculus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257133 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH - Oryctolagus cuniculus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ir 257133 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH prostaglandin F2alpha exhibits contraction of smooth muscles in the uterus, brochus trachea, luteolysis, the initiation of partutition and pain transmission Rattus norvegicus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257133 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH transformation of endogenous prostaglandin D2 to prostaglandin F2alpha Oryctolagus cuniculus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257133 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH - Homo sapiens (5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257140 1.1.1.188 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH - Bos taurus (5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257140 1.1.1.188 4-nitroacetophenone + NADPH high activity Bos taurus ? - ? 230342 1.1.1.188 4-nitrobenzaldehyde + NADPH - Homo sapiens 4-nitrobenzyl alcohol + NADP+ - ? 187462 1.1.1.188 4-nitrobenzaldehyde + NADPH - Bos taurus 4-nitrobenzyl alcohol + NADP+ - ? 187462 1.1.1.188 4-nitrobenzaldehyde + NADPH - Trypanosoma brucei 4-nitrobenzyl alcohol + NADP+ - ? 187462 1.1.1.188 4-nitrobenzaldehyde + NADPH high activity Bos taurus 4-nitrobenzalcohol + NADP+ - ? 383911 1.1.1.188 4-nitrobenzaldehyde + NADPH + H+ - Mus musculus (4-nitrophenyl)methanol + NADP+ - ? 425698 1.1.1.188 4-nitrobenzaldehyde + NADPH + H+ - Homo sapiens (4-nitrophenyl)methanol + NADP+ - ? 425698 1.1.1.188 5beta-androstane-3,17-dione + NADPH - Homo sapiens 5beta-androstan-3alpha-ol-17-one + NADP+ - r 187718 1.1.1.188 5beta-dihydrotestosterone + NADPH - Bos taurus ? - ? 230378 1.1.1.188 9,10-phenanthrenequinone + NADPH - Homo sapiens ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH - Bos taurus ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH - Trypanosoma brucei ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH best substrate Bos taurus ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH i.e. PQ Homo sapiens ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH i.e. PQ Rattus norvegicus ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH i.e. PQ Bos taurus ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH i.e. PQ Oryctolagus cuniculus ? - ? 188352 1.1.1.188 9,10-phenanthrenequinone + NADPH - Homo sapiens ? + NADP+ - ? 230466 1.1.1.188 9,10-phenanthrenequinone + NADPH + H+ - Homo sapiens ? - ? 404116 1.1.1.188 9alpha,11beta-prostaglandin F2 + NADPH + H+ - Mus musculus prostaglandin D2 + NADP+ - r 459136 1.1.1.188 androst-4-ene-3,17-dione + NADPH - Homo sapiens ? + NADP+ - ? 396981 1.1.1.188 cyclohexanone + NADPH - Bos taurus cyclohexanol + NADP+ - ? 187643 1.1.1.188 cyclohexanone + NADPH high activity Bos taurus cyclohexanol + NADP+ - ? 187643 1.1.1.188 D-xylose + NADPH - Bos taurus ? - ? 257059 1.1.1.188 daunorubicin + NADPH high activity Bos taurus ? - ? 230337 1.1.1.188 DL-glyceraldehyde + NADPH - Bos taurus DL-glycerol + NADP+ - ? 257149 1.1.1.188 duroquinone + NADPH - Bos taurus ? - ? 230328 1.1.1.188 hydrindantin + NADPH - Bos taurus ? - ? 188349 1.1.1.188 hydrindantin + NADPH high activity Bos taurus ? - ? 188349 1.1.1.188 menadione + NADPH - Bos taurus ? - ? 187323 1.1.1.188 menadione + NADPH high activity Bos taurus ? - ? 187323 1.1.1.188 additional information two different active sites, one for the endoperoxide group of prostaglandin H2 and the other one for the keto group of prostaglandin D2 and other carbonyl compounds Bos taurus ? - ? 89 1.1.1.188 additional information enzyme interacts with cyclooxygenase 1 and 2, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 Rattus norvegicus ? - ? 89 1.1.1.188 additional information the cytosolic enzyme synergistically interacts with cyclooxygenase 1 and 2, coupling, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 Homo sapiens ? - ? 89 1.1.1.188 additional information acive site structure, enzyme also shows 3alpha-hydroxysteroid dehydrogenase type II activity Homo sapiens ? - ? 89 1.1.1.188 additional information enzyme does not reduce prostaglandins D2 and E2 Trypanosoma brucei ? - ? 89 1.1.1.188 additional information enzyme shows no prostaglandin D2 11-ketoreductase activity, and no glutathione S-transferase activity, although it is similar to the glutathione S-transferase Ovis aries ? - ? 89 1.1.1.188 additional information substrate and product detection by liquid chromatographic-electrospray ionization-mass spectrometry Homo sapiens ? - ? 89 1.1.1.188 additional information Y55 and H117 are involved in catalysis, enzyme also shows 3alpha-hydroxysteroid dehydrogenase type II activity Homo sapiens ? - ? 89 1.1.1.188 additional information coupling ability between cyclooxygenase COX-2 and the prostanoid synthases performing the last stepes in the biosynthesis of prostaglandins PGE2, PGD2, PGF2alpha, and PGI2, regulation, overview, the 20alpha-hydroxysteroid dehydrogenase also shows prostaglandin F synthase activity in the endometrium during luteolysis Mus musculus ? - ? 89 1.1.1.188 additional information the enzyme has dual activity as PGD2 11-ketoreductase and PGH2 9,11-endoperoxide reductase Homo sapiens ? - ? 89 1.1.1.188 additional information the enzyme is important for the production of lyteolytic prostaglandin F2alpha in the endometrium of cows, regulatory mechanisms, overview Bos taurus ? - ? 89 1.1.1.188 additional information the liver-type isozyme possesses two catalytic centres and a broad substrate specificity, D-xylose is a poor substrate, no activity with prostaglandin A1, prostaglandin B2, prostaglandin E2, 4-carboxybenzaldehyde, testosterone, 2,6-dichloroindophenol, D-glucose, D-glucuronic acid, and potassium ferricyanide, overview, the enzyme also exhibits aldose reductase, EC 1.1.1.21, and alcohol dehydrogenase, EC 1.1.1.1, activities, respectively Bos taurus ? - ? 89 1.1.1.188 additional information prostaglandin F synthase and prostaglandin F receptor are involved in the control of testosterone release from Leydig cells and in spermatogenesis via the local pathway and the hypothalamo-hypophysial-testis-pathway Mus musculus ? - ? 89 1.1.1.188 additional information no activity with prostaglandin D2 and prostaglandin E2 Mus musculus ? - ? 89 1.1.1.188 additional information PGFS does not catalyze the reduction of prostaglandin E2 Homo sapiens ? - ? 89 1.1.1.188 additional information in the absence of NADPH or NADP+, enzyme catalyzes the isomerization of prostaglandin H2 to prostaglandin D2 with a Km value of 0.018 mM. This activity activity of AKR1B1 increases with increasing pH, with an optimum of pH 8.5. Residue His110 acts as a base in concert with Asp43 and Lys77 and as an acid to generate PGD2 and PGF2a in the absence of NADPH or NADP+ and in the presence of NADPH, respectively Mus musculus ? - ? 89 1.1.1.188 additional information in the absence of NADPH or NADP+, enzyme catalyzes the isomerization of prostaglandin H2 to prostaglandin D2 with a Km value of 0.023 mM. This activity of AKR1B1 increases with increasing pH, with an optimum of pH 8.5. Residue His110 acts as a base in concert with Asp43 and Lys77 and as an acid to generate PGD2 and PGF2a in the absence of NADPH or NADP+ and in the presence of NADPH, respectively Homo sapiens ? - ? 89 1.1.1.188 additional information no activity with prostaglandin E2 Canis lupus familiaris ? - ? 89 1.1.1.188 additional information AKR1C3 is overexpressed in keloids and mediates the conversion of PGD2 to 9alpha,11beta-PGF2 in keloid and normal fibroblasts Homo sapiens ? - ? 89 1.1.1.188 additional information no activity towards prostaglandin E2 synthesis Canis lupus familiaris ? - ? 89 1.1.1.188 additional information PGFS activity of the recombinant proteins is evaluated using an assay based on in situ generation of the precursor of prostaglandin PGH2 biosynthesis. PGF2alpha is measured by ELISA. Comparisons of PGFS activity of recombinant bovine and human endometrial AKRs, overview Homo sapiens ? - ? 89 1.1.1.188 additional information PGFS activity of the recombinant proteins is evaluated using an assay based on in situ generation of the precursor of prostaglandin PGH2 biosynthesis. PGF2alpha is measured by ELISA. Comparisons of PGFS activity of recombinant bovine and human endometrial AKRs, overview Bos taurus ? - ? 89 1.1.1.188 n-butyraldehyde + NADPH - Bos taurus n-butanol + NADP+ - ? 187586 1.1.1.188 p-nitroacetophenone + NADPH - Bos taurus ? - ? 257143 1.1.1.188 phenylglyoxal + NADPH - Bos taurus ? - ? 187327 1.1.1.188 phenylglyoxal + NADPH high activity Bos taurus ? - ? 187327 1.1.1.188 prostaglandin A2 + NADPH - Bos taurus ? - ? 257151 1.1.1.188 prostaglandin D1 + NADPH - Bos taurus ? - ? 257147 1.1.1.188 prostaglandin D2 + NADP+ - Homo sapiens 9alpha,11beta-prostaglandin F2 + NADPH - ? 438427 1.1.1.188 prostaglandin D2 + NADP+ - Mus musculus 9alpha,11beta-prostaglandin F2 + NADPH + H+ - r 459878 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens prostaglandin 9alpha,11beta-F2 + NADP+ - ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Sus scrofa prostaglandin 9alpha,11beta-F2 + NADP+ - ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens prostaglandin 9alpha,11beta-F2 + NADP+ product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Rattus norvegicus prostaglandin 9alpha,11beta-F2 + NADP+ product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Bos taurus prostaglandin 9alpha,11beta-F2 + NADP+ product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Oryctolagus cuniculus prostaglandin 9alpha,11beta-F2 + NADP+ product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens prostaglandin 9alpha,11beta-F2 + NADP+ i.e. 11-epi PGF2alpha ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Rattus norvegicus prostaglandin 9alpha,11beta-F2 + NADP+ i.e. 11-epi PGF2alpha ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Bos taurus prostaglandin 9alpha,11beta-F2 + NADP+ i.e. 11-epi PGF2alpha ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Oryctolagus cuniculus prostaglandin 9alpha,11beta-F2 + NADP+ i.e. 11-epi PGF2alpha ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ amino acid residues Arg27, Arg91, His170, Arg223, and Asn306 are involved in substrate binding Bos taurus prostaglandin 9alpha,11beta-F2 + NADP+ - ? 371126 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens 9alpha,11beta-prostaglandin F2alpha + NADP+ - r 374446 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens prostaglandin F2alpha + NADP+ - ? 374448 1.1.1.188 prostaglandin D2 + NADPH + H+ - Mus musculus 9alpha,11alpha-prostaglandin F2alpha + NADP+ - ? 383331 1.1.1.188 prostaglandin D2 + NADPH + H+ reaction via formation of the endoperoxide ethanolamide intermediate prostaglandin H2 Homo sapiens 9alpha,11alpha-prostaglandin F2alpha + NADP+ - ? 383331 1.1.1.188 prostaglandin D2 + NADPH + H+ - Mus musculus 9alpha,11beta-prostaglandin F2 + NADP+ - ? 383332 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens 9alpha,11beta-prostaglandin F2 + NADP+ - ? 383332 1.1.1.188 prostaglandin D2 + NADPH + H+ - Bos taurus 9alpha,11beta-prostaglandin F2 + NADP+ - ? 383332 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens 9alpha,11beta-prostaglandin F2alphabeta + NADP+ - ? 383333 1.1.1.188 prostaglandin D2 + NADPH + H+ - Homo sapiens 9-alpha,11-beta-prostaglandin F2 + NADP+ - ? 402883 1.1.1.188 prostaglandin D2 ethanolamide + NADPH i.e. prostamide D2 Homo sapiens prostaglandin 9alpha,11beta-F2 ethanolamide + NADP+ i.e. 91lpha,11beta-prostamide F2 ? 374449 1.1.1.188 prostaglandin D3 + NADPH - Bos taurus ? - ? 257148 1.1.1.188 prostaglandin H2 + NADP+ - Homo sapiens prostaglandin F2alpha + NADPH + H+ - ? 438428 1.1.1.188 prostaglandin H2 + NADP+ - Canis lupus familiaris prostaglandin F2alpha + NADPH + H+ - ? 438428 1.1.1.188 prostaglandin H2 + NADP+ - Felis catus prostaglandin F2alpha + NADPH + H+ - ? 438428 1.1.1.188 prostaglandin H2 + NADP+ - Bos taurus prostaglandin F2alpha + NADPH + H+ - ? 438428 1.1.1.188 prostaglandin H2 + NADPH + H+ - Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257134 1.1.1.188 prostaglandin H2 + NADPH + H+ - Bos taurus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257134 1.1.1.188 prostaglandin H2 + NADPH + H+ - Trypanosoma brucei (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257134 1.1.1.188 prostaglandin H2 + NADPH + H+ aldo-keto reductase has prostaglandin F2alpha synthase activity. AKR1B1 is a more efficient prostaglandin F2alpha synthase than AKR1C3 Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257134 1.1.1.188 prostaglandin H2 + NADPH + H+ aldo-keto reductases AKR1B3 and AKR1B7 have prostaglandin F2alpha synthase activity Mus musculus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ - ? 257134 1.1.1.188 prostaglandin H2 + NADPH + H+ - Mus musculus 9alpha,11beta-prostaglandin F2 + NADP+ - ? 371129 1.1.1.188 prostaglandin H2 + NADPH + H+ - Rattus norvegicus 9alpha,11beta-prostaglandin F2 + NADP+ - ? 371129 1.1.1.188 prostaglandin H2 + NADPH + H+ - Homo sapiens 9alpha,11beta-prostaglandin F2 + NADP+ - ? 371129 1.1.1.188 prostaglandin H2 + NADPH + H+ - Homo sapiens prostaglandin D2 + NADP+ - ? 371130 1.1.1.188 prostaglandin H2 + NADPH + H+ - Rattus norvegicus prostaglandin D2 + NADP+ - ? 371130 1.1.1.188 prostaglandin H2 + NADPH + H+ - Bos taurus prostaglandin D2 + NADP+ - ? 371130 1.1.1.188 prostaglandin H2 + NADPH + H+ - Oryctolagus cuniculus prostaglandin D2 + NADP+ - ? 371130 1.1.1.188 prostaglandin H2 + NADPH + H+ - Mus musculus prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Homo sapiens prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Rattus norvegicus prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Sus scrofa prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Ovis aries prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Trypanosoma brucei prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Canis lupus familiaris prostaglandin F2alpha + NADP+ - r 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Trypanosoma brucei prostaglandin F2alpha + NADP+ no stereochemic determination/identification of the product ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ enzyme also shows PGH2 9-,11-endoperoxide reductase activity Homo sapiens prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ enzyme also shows PGH2 9-,11-endoperoxide reductase activity Rattus norvegicus prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ enzyme also shows PGH2 9-,11-endoperoxide reductase activity Bos taurus prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ enzyme also shows PGH2 9-,11-endoperoxide reductase activity Oryctolagus cuniculus prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ His170 is involved in binding, and Asn306 is critical for catalytic activity Bos taurus prostaglandin F2alpha + NADP+ - ? 371131 1.1.1.188 prostaglandin H2 + NADPH + H+ - Homo sapiens prostaglandin 9alpha,11beta-F2 + NADP+ - ? 374452 1.1.1.188 prostaglandin H2 + NADPH + H+ - Homo sapiens 9alpha,11alpha-prostaglandin F2alpha + NADP+ - ? 383335 1.1.1.188 prostaglandin H2 + NADPH + H+ - Bos taurus 9alpha,11alpha-prostaglandin F2alpha + NADP+ - ? 383335 1.1.1.188 prostaglandin I2 + NADPH - Bos taurus ? - ? 385626 1.1.1.188 prostamide D2 + NADPH + H+ - Homo sapiens 9alpha,11beta-prostamide F2 + NADP+ - ? 415162 1.1.1.188 prostamide H2 + NADPH + H+ about 70% of prostamide H2 is converted to prostamide F2alpha after 2 min at 37°C Homo sapiens prostamide F2alpha + NADP+ - ? 398196 1.1.1.188 retinal + NADPH - Bos taurus retinol + NADP+ - ? 257135 1.1.1.188 testosterone + NADPH + H+ - Trypanosoma brucei ? - ? 230372 1.1.1.188 ubiquinone-10 + NADPH - Bos taurus ? - ? 385870