1.1.1.153 1'-hydroxy-2'-oxopropyltetrahydropterin + NADP+ - Rattus norvegicus L-erythro-tetrahydrobiopterin + NADPH - ? 187319 1.1.1.153 1'-hydroxy-2'-oxopropyltetrahydropterin + NADPH - Rattus norvegicus L-erythrotetrahydrobiopterin + NADP+ - ? 383524 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum D-sepiapterin + NADPH - ? 383002 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum D-sepiapterin + NADPH i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin ? 383002 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum AX2 D-sepiapterin + NADPH - ? 383002 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum AX2 D-sepiapterin + NADPH i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin ? 383002 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH - Dictyostelium discoideum tetrahydrodictyopterin + NADP+ - ? 383003 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH preferred substrate Dictyostelium discoideum tetrahydrodictyopterin + NADP+ - ? 383003 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH - Dictyostelium discoideum AX2 tetrahydrodictyopterin + NADP+ - ? 383003 1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH preferred substrate Dictyostelium discoideum AX2 tetrahydrodictyopterin + NADP+ - ? 383003 1.1.1.153 1'-oxo-2'-hydroxypropyl-tetrahydropterin + NADPH + H+ - Homo sapiens tetrahydrobiopterin + NADP+ - ? 458400 1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum L-sepiapterin + NADPH - ? 383004 1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum L-sepiapterin + NADPH i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin ? 383004 1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum AX2 L-sepiapterin + NADPH - ? 383004 1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - Dictyostelium discoideum AX2 L-sepiapterin + NADPH i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin ? 383004 1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH - Dictyostelium discoideum L-erythro-tetrahydrobiopterin + NADP+ - ? 383005 1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH - Dictyostelium discoideum AX2 L-erythro-tetrahydrobiopterin + NADP+ - ? 383005 1.1.1.153 1,2-cyclohexadione + NADPH - Drosophila melanogaster ? - ? 187337 1.1.1.153 1,2-naphthoquinone + NADPH - Homo sapiens ? - ? 425227 1.1.1.153 1,4-naphthoquinone + NADPH + H+ - Homo sapiens ? - ? 230398 1.1.1.153 1-phenyl-1,2-propanedione + NADPH - Rattus norvegicus ? - ? 187321 1.1.1.153 2,3-butanediol + NADP+ - Rattus norvegicus ? - ? 187329 1.1.1.153 2,3-dimethoxynaphthalene-1,4-dione + NADPH - Homo sapiens ? - ? 425367 1.1.1.153 2,4-pentanedione + NADPH - Rattus norvegicus ? - ? 187328 1.1.1.153 2-amino-6-(2-hydroxypropanoyl)pteridin-4(1H)-one + NADPH + H+ - Rattus norvegicus ? - r 450969 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Gallus gallus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Cavia porcellus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Drosophila melanogaster 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Mus musculus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Mus musculus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Homo sapiens 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Sus scrofa 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Bos taurus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Oryctolagus cuniculus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Dictyostelium discoideum 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Canis lupus familiaris 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Chlorobaculum tepidum 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH in the reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding L-isomers are inactive Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH in the reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding L-isomers are inactive Equus caballus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH equilibrium lies much in favor of dihydrobiopterin formation Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH equilibrium lies much in favor of dihydrobiopterin formation Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH equilibrium lies much in favor of dihydrobiopterin formation Equus caballus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Mus musculus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Homo sapiens 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding D-isomers are inactive Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding D-isomers are inactive Equus caballus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH catalyzes the complete reduction of pyrovoyltetrahydropterin to tetrahydrobiopterin Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Rattus norvegicus Donryu 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Drosophila melanogaster Oregon R 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Rattus norvegicus Sprague-Dawley 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - r 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH - Rattus norvegicus Sprague-Dawley 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Rattus norvegicus Sprague-Dawley 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ - ? 187310 1.1.1.153 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ - Homo sapiens tetrahydrobiopterin + NADP+ - ? 370832 1.1.1.153 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ final step in the synthesis of tetrahydrobiopterin, role in detoxification of exogenous carbonyl compounds suggested Rattus norvegicus tetrahydrobiopterin + NADP+ - ? 370832 1.1.1.153 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ - Chlorobaculum tepidum L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+ - ? 383041 1.1.1.153 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ last step of the de novo tetrahydrobiopterin biosynthesis initiating from GTP Chlorobaculum tepidum L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+ - ? 383041 1.1.1.153 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ last step of the tetrahydrobiopterin biosynthesis Chlorobaculum tepidum L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+ - ? 383041 1.1.1.153 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin, structure-function relationship Chlorobaculum tepidum L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+ - ? 383041 1.1.1.153 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ two reductive steps oxidizing NADPH Chlorobaculum tepidum L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+ - ? 383041 1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+ - Mus musculus 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - ? 383040 1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+ - Homo sapiens 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - ? 383040 1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+ - Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - ? 383040 1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+ 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin is formed by an aldose reductase-like enzyme activity, not by SR Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ - ? 383040 1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH - Mus musculus tetrahydrobiopterin + NADP+ - r 394672 1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH - Homo sapiens tetrahydrobiopterin + NADP+ - r 394672 1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH - Dictyostelium discoideum tetrahydrobiopterin + NADP+ - r 394672 1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH - Homo sapiens tetrahydrobiopterin + NADP+ the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine r 394672 1.1.1.153 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+ - Rattus norvegicus L-erythro-tetrahydrobiopterin + 2 NADP+ - ? 187318 1.1.1.153 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+ - Chlorobaculum tepidum L-threo-tetrahydrobiopterin + 2 NADP+ no formation of the L-erythro isomer ? 370834 1.1.1.153 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+ - Chlorobium limicola L-threo-tetrahydrobiopterin + 2 NADP+ no formation of the L-erythro isomer ? 370834 1.1.1.153 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+ final step in the synthesis of tetrahydrobiopterin Chlorobaculum tepidum L-threo-tetrahydrobiopterin + 2 NADP+ no formation of the L-erythro isomer ? 370834 1.1.1.153 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+ final step in the synthesis of tetrahydrobiopterin Chlorobium limicola L-threo-tetrahydrobiopterin + 2 NADP+ no formation of the L-erythro isomer ? 370834 1.1.1.153 6-pyruvoyltetrahydropterin + NADPH - Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ no synthesis of the D-isomer ? 383042 1.1.1.153 9,10-phenanthrenequinone + NADP+ - Rattus norvegicus ? - ? 187330 1.1.1.153 9,10-phenanthrenequinone + NADPH - Homo sapiens ? - ? 188352 1.1.1.153 acetohexamide + NADPH - Rattus norvegicus ? - ? 187336 1.1.1.153 acetoin + NADPH - Rattus norvegicus ? - ? 187333 1.1.1.153 acetoin + NADPH 0.003 mM NADPH oxidised per 30 min Rattus norvegicus ? - ? 187333 1.1.1.153 acetophenone + NADPH - Rattus norvegicus ? - ? 187332 1.1.1.153 benzil + NADPH - Rattus norvegicus ? - ? 187322 1.1.1.153 benzil + NADPH NADPH-dependent dicarbonyl reductase activity Rattus norvegicus ? - ? 187322 1.1.1.153 benzylacetone + NADPH - Rattus norvegicus ? - ? 187335 1.1.1.153 diacetyl + NADPH - Drosophila melanogaster ? - ? 187325 1.1.1.153 diacetyl + NADPH - Rattus norvegicus ? - ? 187325 1.1.1.153 diacetyl + NADPH - Chlorobaculum tepidum ? - ? 187325 1.1.1.153 diacetyl + NADPH - Drosophila melanogaster Oregon R ? - ? 187325 1.1.1.153 diacetyl + NADPH NADPH-dependent dicarbonyl reductase activity Rattus norvegicus acetoin + NADP+ - ? 384603 1.1.1.153 dihydrotepidopterin + NADP+ 15% relative activity Chlorobaculum tepidum ? - ? 187317 1.1.1.153 isosepiapterin + NADPH - Equus caballus 6-(1-hydroxypropyl)-dihydropterin + NADP+ - ? 187311 1.1.1.153 isosepiapterin + NADPH - Equus caballus ? + NADP+ - r 384947 1.1.1.153 L-erythro-dihydrobiopterin + NADP+ - Chlorobaculum tepidum ? - ? 187316 1.1.1.153 L-erythro-dihydroneopterin + NADP+ D-isomer completely inactive Equus caballus ? - r 187313 1.1.1.153 L-erythro-dihydroneopterin + NADP+ very slow activity, no activity with the D-isomer Equus caballus ? - r 187313 1.1.1.153 L-threo-dihydrobiopterin + NADP+ D-isomer 45% relative activity Chlorobaculum tepidum ? - r 187315 1.1.1.153 L-threo-dihydroneopterin + NADP+ - Chlorobaculum tepidum ? - ? 187314 1.1.1.153 L-threo-dihydroneopterin + NADP+ D-isomer completely inactive Equus caballus ? - r 187314 1.1.1.153 L-threo-dihydroneopterin + NADP+ very slow activity, no activity with the D-isomer Equus caballus ? - r 187314 1.1.1.153 lactoyltetrahydropterin + NADPH - Rattus norvegicus L-erythrotetrahydrobiopterin + NADP+ - ? 385072 1.1.1.153 lactoyltetrahydropterin + NADPH + H+ - Rattus norvegicus L-erythro-tetrahydrobiopterin + NADP+ - ? 187320 1.1.1.153 menadione + NADPH - Drosophila melanogaster ? - ? 187323 1.1.1.153 menadione + NADPH - Homo sapiens ? - ? 187323 1.1.1.153 menadione + NADPH - Rattus norvegicus ? - ? 187323 1.1.1.153 menadione + NADPH - Drosophila melanogaster Oregon R ? - ? 187323 1.1.1.153 methylglyoxal + NADPH - Drosophila melanogaster ? - ? 187326 1.1.1.153 methylglyoxal + NADPH - Rattus norvegicus ? - ? 187326 1.1.1.153 methylglyoxal + NADPH - Drosophila melanogaster Oregon R ? - ? 187326 1.1.1.153 additional information enzyme is quite similar to general aldo-keto reductases, especially to carbonyl reductase Rattus norvegicus ? - ? 89 1.1.1.153 additional information some monoketotestosterones show slight activity Rattus norvegicus ? - ? 89 1.1.1.153 additional information not: 6-acetyl-7-methyldihydropterin Rattus norvegicus ? - ? 89 1.1.1.153 additional information not: 6-acetyl-7-methyldihydropterin Equus caballus ? - ? 89 1.1.1.153 additional information not: methylglyoxal, menadione Chlorobaculum tepidum ? - ? 89 1.1.1.153 additional information enzyme also catalyzes the isomerization of 6-1'-oxo-2'-hydroxypropyl tetrahydropterin (6-lactoyltetrahydropterin) to 6-1'-hydroxy-2'-oxopropyltetrahydropterin Rattus norvegicus ? - ? 89 1.1.1.153 additional information product determination Dictyostelium discoideum ? - ? 89 1.1.1.153 additional information final step in the synthesis of tetrahydrobiopterin Mus musculus ? - ? 89 1.1.1.153 additional information final step in the synthesis of tetrahydrobiopterin Homo sapiens ? - ? 89 1.1.1.153 additional information final step in the synthesis of tetrahydrobiopterin Rattus norvegicus ? - ? 89 1.1.1.153 additional information important in the metabolism of tetrahydrobiopterin and sepiapterin Oryzias latipes ? - ? 89 1.1.1.153 additional information D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 Dictyostelium discoideum ? - ? 89 1.1.1.153 additional information quantitative in vivo assay and product determination Dictyostelium discoideum ? - ? 89 1.1.1.153 additional information the enzyme is involved in the tetrahydrobiopterin biosynthesis Homo sapiens ? - ? 89 1.1.1.153 additional information the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins Rattus norvegicus ? - ? 89 1.1.1.153 additional information descending substrate preference: sepiapterin, lactoyltetrahydropterin, pyruvoyltetrahydropterin, 1'-hydroxy-2'-oxopropyltetrahydropterin Rattus norvegicus ? - ? 89 1.1.1.153 additional information no activity with 6-acetyl-7-methyl-7,8-dihydropterin Equus caballus ? - ? 89 1.1.1.153 additional information substrate specificity, the enzyme also exhibits non-specific NADPH-dependent dicarbonyl reductase activity, overview Rattus norvegicus ? - ? 89 1.1.1.153 additional information sepiapterin or dihydrobiopterin are the precursors of the tetrahydrobiopterin-salvage pathway, enzyme activity and pathway regulation in vivo, overview Homo sapiens ? - ? 89 1.1.1.153 additional information tetrahydropteridines in Dictyostelium are associated with mitochondrial function, probably via direct protection against oxidative stress, tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2 Dictyostelium discoideum ? - ? 89 1.1.1.153 additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis Homo sapiens ? - ? 89 1.1.1.153 additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis Dictyostelium discoideum ? - ? 89 1.1.1.153 additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue Homo sapiens ? - ? 89 1.1.1.153 additional information native ornithine decarboxylase, EC 4.1.1.17, and sepiapterin reductase physically interact, in silico protein-protein docking simulations Homo sapiens ? - ? 89 1.1.1.153 additional information physical interaction between key polyamines biosynthesis enzyme ornithine decarboxylase (ODC) and sepiapterin reductase (SPR) Homo sapiens ? - ? 89 1.1.1.153 additional information the enzyme's one-electron reduction of redox cycling chemicals, such as menadione, generates radical cations. The rapid reaction of these cations with molecular oxygen regenerates the redox active chemical, and in the process superoxide anion is formed. Sepiapterin reduction is catalyzed by NADPH, whereas chemical redox cycling is catalyzed by NADPH and/or NADH, overview Homo sapiens ? - ? 89 1.1.1.153 additional information the enzyme's one-electron reduction of redox cycling chemicals, such as menadione, generates radical cations. The rapid reaction of these cations with molecular oxygen regenerates the redox active chemical, and in the process superoxide anion is formed. Sepiapterin reduction is catalyzed by NADPH, whereas chemical redox cycling is catalyzed by NADPH and/or NADH, overview Rattus norvegicus ? - ? 89 1.1.1.153 additional information the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins Rattus norvegicus Sprague-Dawley ? - ? 89 1.1.1.153 additional information product determination Dictyostelium discoideum AX2 ? - ? 89 1.1.1.153 additional information quantitative in vivo assay and product determination Dictyostelium discoideum AX2 ? - ? 89 1.1.1.153 additional information D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 Dictyostelium discoideum AX2 ? - ? 89 1.1.1.153 p-nitrobenzaldehyde + NADPH - Drosophila melanogaster p-nitrobenzyl alcohol + NADP+ - ? 187331 1.1.1.153 p-nitrobenzaldehyde + NADPH - Rattus norvegicus p-nitrobenzyl alcohol + NADP+ - ? 187331 1.1.1.153 p-quinone + NADPH - Rattus norvegicus ? - ? 187324 1.1.1.153 phenylglyoxal + NADPH - Drosophila melanogaster ? - ? 187327 1.1.1.153 phenylglyoxal + NADPH - Rattus norvegicus ? - ? 187327 1.1.1.153 phenylglyoxal + NADPH - Chlorobaculum tepidum ? - ? 187327 1.1.1.153 phenylglyoxal + NADPH - Drosophila melanogaster Oregon R ? - ? 187327 1.1.1.153 phenylpropanedione + NADPH NADPH-dependent dicarbonyl reductase activity Rattus norvegicus phenylpropan-2,3-diol + NADP+ - ? 385545 1.1.1.153 propiophenone + NADPH - Rattus norvegicus ? - ? 187334 1.1.1.153 pyruvoyltetrahydropterin + NADPH - Rattus norvegicus L-erythrotetrahydrobiopterin + NADP+ - ? 385655 1.1.1.153 sepiapterin + NADPH + H+ - Mus musculus 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Mus musculus 7,8-dihydrobiopterin + NADP+ - r 374626 1.1.1.153 sepiapterin + NADPH + H+ - Homo sapiens 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Homo sapiens 7,8-dihydrobiopterin + NADP+ - r 374626 1.1.1.153 sepiapterin + NADPH + H+ - Rattus norvegicus 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Rattus norvegicus 7,8-dihydrobiopterin + NADP+ - r 374626 1.1.1.153 sepiapterin + NADPH + H+ - Bombyx mori 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Dictyostelium discoideum 7,8-dihydrobiopterin + NADP+ - r 374626 1.1.1.153 sepiapterin + NADPH + H+ - Equus caballus 7,8-dihydrobiopterin + NADP+ - r 374626 1.1.1.153 sepiapterin + NADPH + H+ - Chlorobaculum tepidum 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Chlorobium limicola 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Bos taurus 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Musca domestica 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Rattus norvegicus 7,8-dihydrobiopterin + NADP+ detailed product determination and analysis using fluorescent substrates, 7,8-dihydrobiopterin can be oxidized nonenzymatically to biopterin ? 374626 1.1.1.153 sepiapterin + NADPH + H+ i.e. 2-amino-4-hydroxy-6-lactyl-7,8-dihydropteridine, biosynthesis pathway, overview Rattus norvegicus 7,8-dihydrobiopterin + NADP+ i.e. 2-amino-4-hydroxy-6-(1',2'-dihydroxypropyl-)7,8-dihydropteridine, which is a substrate for biosynthesis of tetrahydrobiopterin, i.e. 6R-L-erythro-1',2'-dihydroxy-propyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine, an important component for controling the concentration of catecholamines or indoleamines in the brain and other nerve tissues ? 374626 1.1.1.153 sepiapterin + NADPH + H+ sepiapterin reductase activity Rattus norvegicus 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ cellular uptake of sepiapterin across the cell membrane results in an efficient accumulation of tetrahydrobiopterin, sepiapterin relocates across the plasma membrane via two distinct paths, the slower path connects to the cytosolic compartment, overview Homo sapiens 7,8-dihydrobiopterin + NADP+ - r 374626 1.1.1.153 sepiapterin + NADPH + H+ no stereochemic specification in the publication Homo sapiens 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ no stereochemic specification in the publication Rattus norvegicus 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ - Rattus norvegicus Sprague-Dawley 7,8-dihydrobiopterin + NADP+ - ? 374626 1.1.1.153 sepiapterin + NADPH + H+ best substrate Rattus norvegicus dihydrobiopterin + NADP+ - ? 385725 1.1.1.153 sepiapterin + NADPH + H+ - Homo sapiens tetrahydrobiopterin + NADP+ no stereochemic specification in the publication ? 438462 1.1.1.153 sepiapterin + NADPH + H+ - Musca domestica tetrahydrobiopterin + NADP+ no stereochemic specification in the publication ? 438462 1.1.1.153 sepiapterin + NADPH + H+ - Homo sapiens tetrahydrobiopterin + NADP+ no stereochemic specification of the substrate in the publication ? 438462 1.1.1.153 sepiapterin + NADPH + H+ - Homo sapiens L-erythro-7,8-dihydrobiopterin + NADP+ - ? 458687 1.1.1.153 xanthopterin B2 + NADPH - Equus caballus 6-(1',2'-dihydroxypropyl)-dihydrolumazine + NADP+ - ? 187312 1.1.1.153 xanthopterin-B2 + NADPH - Equus caballus ? + NADP+ - r 385928