6.5.1.3	additional information	the group I intron from cyanobacterium Anabaena sp. catalyzes phosphodiester bond formation using a triphosphate on the 5'-terminal nucleotide, much like protein polymerases and engineered ribozymes. In the process, this ribozyme forms a unique circular RNA that incorporates the exogenous guanosine cofactor added during self-splicing	Anabaena sp.	?	-	?	89	
6.5.1.3	ATP + (ribonucleotide)n + (ribonucleotide)m	-	Branchiostoma floridae	AMP + diphosphate + (ribonucleotide)n+m	-	?	813	
6.5.1.3	additional information	the RNA ligase has a a strict requirement for RNA substrates with a 2'-phosphate terminus for the ligation of RNAs with 5'-phosphate and 3'-hydroxyl ends. RNA ligase forms a 2'-phosphomonoester-3',5'-phosphodiester junction	Branchiostoma floridae	?	-	?	89	
6.5.1.3	ATP + (ribonucleotide)n + (ribonucleotide)m	DraRnl seals 3'-OH/5'-PO4 RNA nicks in either a duplex RNA or an RNA:DNA hybrid, but it cannot seal 3'-OH/5'-PO4 DNA nicks	Deinococcus radiodurans	AMP + diphosphate + (ribonucleotide)n+m	-	?	813	
6.5.1.3	ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m	-	Diplonema papillatum	(ribonucleotide)n+m + AMP + diphosphate	-	?	444214	
6.5.1.3	ATP + (ribonucleotide)n + (ribonucleotide)m	the L1 ligase is regioselective for formation of the biologically relevant 5' to 3' phosphodiester bond rather than a 5' to 2' bond	Enterobacteria phage L1	AMP + diphosphate + (ribonucleotide)n+m	-	?	813	
6.5.1.3	ATP + (ribonucleotide)n + (ribonucleotide)m	T4 RNA ligase 1 can efficiently adenylate DNA oligos with 5' phosphate and 3' blocking group	Escherichia coli	AMP + diphosphate + (ribonucleotide)n+m	-	?	813	
6.5.1.3	additional information	RtcA is able of cyclizing a 2'-phosphate RNA end in high yield. The rate of 2'-phosphate cyclization by RtcA is five orders of magnitude slower than 3'-phosphate cyclization, notwithstanding that RtcA binds with similar affinity to RNA3'p and RNA2'p substrates	Escherichia coli	?	-	?	89	
6.5.1.3	ATP + (ribonucleotide)n + (ribonucleotide)m	-	Homo sapiens	AMP + diphosphate + (ribonucleotide)n+m	-	?	813	
6.5.1.3	dATP + (ribonucleotide)n + (ribonucleotide)m	-	Homo sapiens	dAMP + phosphate + (ribonucleotide)n+m	-	?	814