3.4.22.64	additional information	enzyme is involved in cytokine activation	?	-	?	89	
3.4.22.64	additional information	Flightless-I regulates the subcellular distribution of caspase-11 by promoting its localization at the cell leading edge	?	-	?	89	
3.4.22.64	cationic channel subunit transient receptor potential channel 1 + H2O	i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses	?	-	?	430923	
3.4.22.64	mouse interleukin-18 + H2O	low activity	?	-	?	465330	
3.4.22.64	additional information	mouse caspase-11 cannot cleave IL-1beta efficiently	?	-	-	89	
3.4.22.64	additional information	mouse caspase-11 has an inadequate capacity to cleave pro-IL-1beta. It cleaves gasdermin D more efficiently than pro-IL-1beta	?	-	-	89	
3.4.22.64	additional information	neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice	?	-	?	89	
3.4.22.64	additional information	neurotoxicity of 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine may be mediated via activation of the caspase-11 cascade and inflammatory cascade, as well as the mitochondrial apoptotic cascade	?	-	?	89	
3.4.22.64	additional information	optimal cleavage site is IEHD, LEHD, VEHD or PEHD	?	-	?	89	
3.4.22.64	additional information	other caspases are substrates of caspase-11	?	-	?	89