3.4.22.64 acetyl-VEHD-7-amido-4-methylcoumarin + H2O - acetyl-VEHD + 7-amino-4-methylcoumarin - ? 361994 3.4.22.64 acetyl-WEHD-7-amido-4-methylcoumarin + H2O - acetyl-WEHD + 7-amino-4-methylcoumarin - ? 362386 3.4.22.64 caspase-1 + H2O - ? - ? 418538 3.4.22.64 cationic channel subunit transient receptor potential channel 1 + H2O i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses ? - ? 430923 3.4.22.64 cationic channel subunit transient receptor potential channel 1 + H2O - ? - ? 430923 3.4.22.64 DABYL-GQLSLLSDGID-Glu + H2O synthetic substrate ? - ? 468854 3.4.22.64 gasdermin D + H2O - ? - ? 412076 3.4.22.64 gasdermin D + H2O cleavage of gasdermin D (GSDMD) into pore-forming peptides ? - ? 412076 3.4.22.64 gasdermin D + H2O - gasdermin fragment p30 + gasdermin fragment p20 - ? 448598 3.4.22.64 gasdermin D + H2O - N-terminal domain of gasdermin D + C-terminal domain of gasdermin D - ? 465101 3.4.22.64 gasdermin-D + H2O - ? - ? 465102 3.4.22.64 human interleukin-18 + H2O - ? - ? 469682 3.4.22.64 additional information optimal cleavage site is IEHD, LEHD, VEHD or PEHD ? - ? 89 3.4.22.64 additional information - ? - ? 89 3.4.22.64 additional information overexpression induces apoptosis ? - ? 89 3.4.22.64 additional information phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock ? - ? 89 3.4.22.64 additional information the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS ? - ? 89 3.4.22.64 additional information enzyme is involved in cytokine activation ? - ? 89 3.4.22.64 additional information pro-caspase-11 physically interacts with pro-ICE in cells, the expression of casp-11 is essential for activation of ICE. Caspase-11 is a compinent of ICE complex and is required for the activation of ICE. Important role of ICE and caspase-11 in mediating apoptosis in pathological conditions ? - ? 89 3.4.22.64 additional information the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE ? - ? 89 3.4.22.64 additional information the enzyme is involved in cytokine activation ? - ? 89 3.4.22.64 additional information neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice ? - ? 89 3.4.22.64 additional information C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation ? - ? 89 3.4.22.64 additional information neurotoxicity of 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine may be mediated via activation of the caspase-11 cascade and inflammatory cascade, as well as the mitochondrial apoptotic cascade ? - ? 89 3.4.22.64 additional information caspase-11 plays a crucial role in both inflammation and apoptosis. Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin (IL)-1 and IL-18, but also activates caspase-3, leading to cellular apoptosis under pathological conditions. The expression of caspase-11 is strongly induced at both mRNA and protein levels by inflammatory stimuli such as lipopolysaccharide, interferon-Q Q, and tumor necrosis factor-K K in C6 rat glial cells as well as primary astrocytes. Induction of caspase-11 by LPS in astrocytes is mediated through the p38 MAPK pathway. Inflammatory induction of caspase-11 in astrocytes may play an important role in both inflammatory responses involving these cells and auto-regulatory apoptosis of activated astrocytes in inflammatory sites ? - ? 89 3.4.22.64 additional information caspase-11 has a regulatory role in ethanol-induced apoptosis. Suppression of caspase-11 expression may be a mechanism by which Scutellariae radix (Chinese herbal medicine) exerts its cytoprotective effect ? - ? 89 3.4.22.64 additional information caspase-11 may be a central regulator of multiple events, including cell migration, cytokine maturation and apoptosis, during inflammation responses. Caspase-11 interacts physically and functionally with actin interacting protein 1, an activator of cofilin-mediated actin depolymerization. Caspase-11 and actin interacting protein 1 work cooperatively to promote cofilin-mediated actin depolymerization ? - ? 89 3.4.22.64 additional information a pathway modulating inflammatory-cell migration involve caspase-11 and actin interacting protein 1 ? - ? 89 3.4.22.64 additional information Flightless-I regulates the subcellular distribution of caspase-11 by promoting its localization at the cell leading edge ? - ? 89 3.4.22.64 additional information other caspases are substrates of caspase-11 ? - ? 89 3.4.22.64 additional information dimerised caspase-11 cannot cleave pro-interleukin-1beta of either species, mouse or human ? - - 89 3.4.22.64 additional information mouse caspase-11 cannot cleave IL-1beta efficiently ? - - 89 3.4.22.64 additional information mouse caspase-11 has an inadequate capacity to cleave pro-IL-1beta. It cleaves gasdermin D more efficiently than pro-IL-1beta ? - - 89 3.4.22.64 mouse interleukin-18 + H2O low activity ? - ? 465330 3.4.22.64 Pro-interleukin-1beta + H2O - ? - ? 432907 3.4.22.64 procaspase-1 + H2O the enzyme is an upstream activator of caspase-1 ? - ? 362372 3.4.22.64 procaspase-1 + H2O - ? - ? 362372 3.4.22.64 procaspase-3 + H2O - ? - ? 362371 3.4.22.64 procaspase-3 + H2O the enzyme is a critical initiator caspase responsible for the activation of caspase-3 ? - ? 362371