3.4.22.64	gasdermin-D + H2O	-	?	-	?	465102	
3.4.22.64	human interleukin-18 + H2O	-	?	-	?	469682	
3.4.22.64	additional information	optimal cleavage site is IEHD, LEHD, VEHD or PEHD	?	-	?	89	
3.4.22.64	additional information	-	?	-	?	89	
3.4.22.64	additional information	overexpression induces apoptosis	?	-	?	89	
3.4.22.64	additional information	phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock	?	-	?	89	
3.4.22.64	additional information	the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS	?	-	?	89	
3.4.22.64	additional information	enzyme is involved in cytokine activation	?	-	?	89	
3.4.22.64	additional information	pro-caspase-11 physically interacts with pro-ICE in cells, the expression of casp-11 is essential for activation of ICE. Caspase-11 is a compinent of ICE complex and is required for the activation of ICE. Important role of ICE and caspase-11 in mediating apoptosis in pathological conditions	?	-	?	89	
3.4.22.64	additional information	the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE	?	-	?	89