3.1.3.56 1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate + H2O moderate activity 1-diphosphoinositol 2,3,4,6-tetrakisphosphate + phosphate - ? 446549 3.1.3.56 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O - phosphatidylinositol 4-phosphate + phosphate - ? 360884 3.1.3.56 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels phosphatidylinositol 4-phosphate + phosphate - ? 360884 3.1.3.56 1-diphosphoinositol 2,3,4,5,6-pentakisphosphate + H2O low activity ? - ? 446558 3.1.3.56 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O - 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate - ? 380868 3.1.3.56 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O - 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate - ? 380869 3.1.3.56 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate - ? 380442 3.1.3.56 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O preferred substrate 1D-myo-inositol 1,2,3,4-tetrakisphosphate + phosphate - ? 380873 3.1.3.56 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O - 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate - ? 380874 3.1.3.56 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O - 1D-myo-inositol 1,2,4-trisphosphate + phosphate - ? 380875 3.1.3.56 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O - 1D-myo-inositol 1,3,4-trisphosphate + phosphate - ? 380443 3.1.3.56 1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O - 1D-myo-inositol 1,4,6-trisphosphate + phosphate - ? 380876 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O specific for 1D-myo-inositol 1,4-bisphosphate + phosphate - ? 380444 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O 1D-myo-inositol 1,4,5-trisphosphate metabolism, regulation, overview 1D-myo-inositol 1,4-bisphosphate + phosphate - ? 380444 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O the enzyme is involved in Ins(1,4,5)P3-mediated Ca2+ signaling associated to PRIP-1, a Ins(1,4,5)P3-binding protein, overview 1D-myo-inositol 1,4-bisphosphate + phosphate - ? 380444 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O the enzyme is involved in the metabolism of polyphosphoinisotide in cellular signalling 1D-myo-inositol 1,4-bisphosphate + phosphate - ? 380444 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O - 1D-myo-inositol 1,4-bisphosphate + phosphate - ? 380444 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O absolutely specific for 1D-myo-inositol 1,4-bisphosphate + phosphate - ? 380444 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O recombinant purified enzyme expressed in Escherichia coli 1D-myo-inositol 1,4-bisphosphate + phosphate - ? 380444 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O - 1D-myo-inositol 1,4-disphosphate + phosphate - ? 390571 3.1.3.56 1D-myo-inositol 1,4,5-trisphosphate + H2O - myo-inositol 1,4-bisphosphate + phosphate - ? 429132 3.1.3.56 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O - 1D-myo-inositol 2,4,6-trisphosphate + phosphate - ? 380877 3.1.3.56 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O low activity 1D-myo-inositol 2,4,6-trisphosphate + phosphate - ? 380877 3.1.3.56 1D-myo-inositol 2,4,5-trisphosphate + H2O preferred substrate 1D-myo-inositol 2,4-bisphosphate + phosphate - ? 380878 3.1.3.56 1D-myo-inositol 3,4,5-trisphosphate + H2O - 1D-myo-inositol 3,4-bisphosphate + phosphate - ? 429133 3.1.3.56 1D-myo-inositol 3,5-bisphosphate + H2O - 1D-myo-inositol 3-phosphate + phosphate - ? 429134 3.1.3.56 1D-myo-inositol 4,5,6-trisphosphate + H2O - 1D-myo-inositol 4,6-bisphosphate + phosphate - ? 380879 3.1.3.56 3-hydroxybenzene 1,2,4-trisphosphate + H2O this is the first example of its kind to illustrate that an unnatural aromatic polyphosphorylated molecule can be specifically dephosphorylated by type I Ins(1,4,5)P3 5-phosphatase. No reaction with benzene 1,2,4-trisphosphate 2,3-dihydroxybenzene 1,4-bisphosphate + phosphate - ? 390736 3.1.3.56 3-O-methylfluorescein phosphate + H2O - 3-O-methylfluorescein + phosphate - ? 381105 3.1.3.56 4-diphosphoinositol 1,2,3,5,6-pentakisphosphate + H2O low activity ? - ? 446715 3.1.3.56 4-nitrophenyl phosphate + H2O - 4-nitrophenol + phosphate - ? 73771 3.1.3.56 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate + H2O best substrate myo-inositol hexakisphosphate + phosphate - ? 446868 3.1.3.56 5-diphosphoinositol 1,3,4,6-tetrakisphosphate + H2O moderate to low activity inositol-1,3,4,5,6-pentakisphosphate + phosphate - ? 446869 3.1.3.56 6-diphosphoinositol 1,2,3,4,5-pentakisphosphate + H2O low activity ? - ? 446885 3.1.3.56 7-methyl-6-thioguanosine + H2O spectrophotometric continous coupled enzyme assay substrate 7-methyl-6-thioguanine + ribose 1-phosphate - ? 381276 3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O - D-myo-inositol 1,3,4-trisphosphate + phosphate - ? 360881 3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O very poor substrate D-myo-inositol 1,3,4-trisphosphate + phosphate - ? 360881 3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O substrate for type I but not type II enzyme D-myo-inositol 1,3,4-trisphosphate + phosphate - ? 360881 3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O at 8% of the rate of inositol 1,4,5-trisphosphate hydrolysis D-myo-inositol 1,3,4-trisphosphate + phosphate - ? 360881 3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O type I and type II enzyme D-myo-inositol 1,3,4-trisphosphate + phosphate - ? 360881 3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate D-myo-inositol 1,3,4-trisphosphate + phosphate - ? 360881 3.1.3.56 D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O poor substrate D-myo-inositol 1,4,6-trisphosphate + phosphate - ? 360886 3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O - D-myo-inositol 1,4-bisphosphate + phosphate - ? 360879 3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O involved in regulation of excitation-contraction coupling in skeletal muscle D-myo-inositol 1,4-bisphosphate + phosphate - ? 360879 3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate - ? 360879 3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O - myo-inositol 1,4-bisphosphate + phosphate - ? 468806 3.1.3.56 glycerophosphoinositol 4,5-bisphosphate + H2O at 13% of the rate of inositol 1,4,5-trisphosphate hydrolysis glycerophosphoinositol 4-phosphate + phosphate - ? 360880 3.1.3.56 inositol 1,2-cyclic 4,5-trisphosphate + H2O poor substrate ? - ? 360882 3.1.3.56 inositol 4,5-bisphosphate + H2O - inositol 4-phosphate + phosphate - ? 360883 3.1.3.56 additional information glycerophosphoinositol 4-phosphate and inositol 1,4-bisphosphate are not hydrolyzed ? - ? 89 3.1.3.56 additional information glycerophosphoinositol 4,5-bisphosphate is not hydrolyzed ? - ? 89 3.1.3.56 additional information D-6-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate are not hydrolyzed ? - ? 89 3.1.3.56 additional information the enzyme has multiple roles in cellular signalling and may regulate distinct pathways ? - ? 89 3.1.3.56 additional information enzyme knockout results in decrease in nucleocytoplasmic inositol phosphate 6-/3-kinases Ipk2/Ipk1-dependent inositol hexakisphosphate synthesis, overview ? - ? 89 3.1.3.56 additional information substrate specificity, no activity with 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1D-myo-inositol 1,5-bisphosphate, 1D-myo-inositol 1,3,5-trisphosphate, and with alpha-D-glucose 1-phosphate, D-glucose 6-phosphate, and alpha-D,L-glycerophosphate, overview ? - ? 89 3.1.3.56 additional information substrate specificity, no activity with 1D-myo-inositol 1,4,5-trisphosphate, 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1D-myo-inositol 1,5-bisphosphate, and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, overview ? - ? 89 3.1.3.56 additional information substrate specificity, no activity with 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate, 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1-phosphatidyl-1D-myo-inositol 4-phosphate, and 1-phosphatidyl-1D-myo-inositol 3-phosphate ? - ? 89 3.1.3.56 additional information the enzyme binds to PRIP-1, a Ins(1,4,5)P3-binding protein, via the protein's PH-domain, which inhibits the enzyme activity ? - ? 89 3.1.3.56 additional information enzyme only binds soluble inositol polyphosphates ? - ? 89 3.1.3.56 additional information isofom SHIP2 is unable to dephosphorylate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate ? - ? 89 3.1.3.56 additional information the enzyme shows high activity and exquisite specificity for the 5-diphosphate group of inositol diphosphates (5-PP-InsP), substrate-binding pocket structure analysis, overview. No activity with inositol hexakisphosphate, poor activity with 2-diphosphoinositol 1,3,4,5,6-pentakisphosphate and 3-diphosphoinositol 1,2,4,5,6-pentakisphosphate. Enzyme Siw14 also acts as protein tyrosine phosphatase, EC 3.1.3.48 ? - ? 89 3.1.3.56 phosphatidyl-L-myo-inositol 3,4,5-trisphosphate + H2O - phosphatidylinositol 3,4-bisphosphate + phosphate - ? 360885