2.7.12.2 additional information TNF-alpha receptor signaling regulates epithelial cell secretion of inflammation and invasion mediators involving signaling through IkappaB kinase complex 2, IKB, nuclear factor kappaB, extracellular signal-regulated kinase, mitogen-activated protein kinase kinase, p38, and phosphatidylinositol 3-kinase, and Akt1/2. MEK, p38, and IKK inhibitors block TNF-alpha-induced IL-8, IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not, overview Homo sapiens ? - ? 89 2.7.12.2 ATP + poly-(Tyr-Glu) tyrosine kinase substrate Saccharomyces cerevisiae ADP + phospho-poly-(Tyr-Glu) - ? 379462 2.7.12.2 ATP + protein tyrosine/threonine kinase Rattus norvegicus ADP + phosphoprotein - ? 323335 2.7.12.2 ATP + VdHog1 VdHog1 is a mitogen-activated protein kinase, MAPK Verticillium dahliae ADP + phosphorylated VdHog1 - ? 438255 2.7.12.2 ATP + VdHog1 VdHog1 is a mitogen-activated protein kinase, MAPK Verticillium dahliae XS11 ADP + phosphorylated VdHog1 - ? 438255