2.7.11.10 ATP + a protein autophosphorylation at both Ser and Thr Myxococcus xanthus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection Mus musculus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein the expression of pkn1 is developmentally regulated to start immediately before spore formation. The enzyme plays an important role in the onset of proper differentiation Myxococcus xanthus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses Mus musculus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling Mus musculus ADP + phosphorylated Bcl - ? 386259 2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling Homo sapiens ADP + phosphorylated Bcl - ? 386259