2.7.11.10	ATP + [IkappaB protein]	-	Canis lupus familiaris	ADP + [IkappaB phosphoprotein]	-	?	378623	
2.7.11.10	ATP + a protein	CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway	Homo sapiens	ADP + a phosphoprotein	-	?	323385	
2.7.11.10	ATP + a protein	the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection	Homo sapiens	ADP + a phosphoprotein	-	?	323385	
2.7.11.10	ATP + a protein	phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB	Homo sapiens	ADP + a phosphoprotein	-	?	323385	
2.7.11.10	ATP + a protein	phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses	Homo sapiens	ADP + a phosphoprotein	-	?	323385	
2.7.11.10	ATP + Bcl	phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling	Homo sapiens	ADP + phosphorylated Bcl	-	?	386259	
2.7.11.10	ATP + Bcl	phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl	Homo sapiens	ADP + phosphorylated Bcl	-	?	386259	
2.7.11.10	ATP + Bcl	Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl	Homo sapiens	ADP + phosphorylated Bcl10	-	?	387972	
2.7.11.10	ATP + Bcl10	negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview	Homo sapiens	ADP + phosphorylated Bcl10	-	?	386258	
2.7.11.10	ATP + GST-IkappaBalpha	activity assay	Homo sapiens	ADP + GST-IkappaBalpha phosphoprotein	-	?	408547