2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl Mus musculus ADP + phosphorylated Bcl - ? 386259 2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl Homo sapiens ADP + phosphorylated Bcl - ? 386259 2.7.11.10 ATP + Bcl Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl Homo sapiens ADP + phosphorylated Bcl10 - ? 387972 2.7.11.10 ATP + Bcl10 negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview Homo sapiens ADP + phosphorylated Bcl10 - ? 386258 2.7.11.10 ATP + GST-IkappaBalpha activity assay Homo sapiens ADP + GST-IkappaBalpha phosphoprotein - ? 408547 2.7.11.10 ATP + IkappaB alpha - Homo sapiens ADP + phosphorylated IkappaB alpha - ? 400182 2.7.11.10 ATP + IkappaB protein the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages Mus musculus ADP + phosphorylated IkappaB - ? 386292 2.7.11.10 ATP + IkappaB protein - Homo sapiens ADP + IkappaB phosphoprotein - ? 400183 2.7.11.10 ATP + IkappaBalpha - Homo sapiens ADP + phosphorylated IkappaBalpha - ? 379371 2.7.11.10 ATP + IkappaBalpha a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer Homo sapiens ADP + phosphorylated IkappaBalpha - ? 379371