1.13.11.6 3-hydroxy-4-methylanthranilic acid + O2 - ? - ? 375809 1.13.11.6 3-hydroxyanthranilate + O2 - 2-amino-3-carboxymuconate semialdehyde - ? 288851 1.13.11.6 3-hydroxyanthranilate + O2 - 2-amino-3-carboxymuconate semialdehyde - r 288851 1.13.11.6 3-hydroxyanthranilate + O2 in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ 2-amino-3-carboxymuconate semialdehyde - ? 288851 1.13.11.6 3-hydroxyanthranilate + O2 enzyme occurs in the metabolic pathway of the conversion of tryptophan to nicotinic acid 2-amino-3-carboxymuconate semialdehyde - ? 288851 1.13.11.6 3-hydroxyanthranilate + O2 biosynthetic enzyme of the endogenous excitotoxin quinolinic acid 2-amino-3-carboxymuconate semialdehyde - ? 288851 1.13.11.6 3-hydroxyanthranilate + O2 in the kynurenine pathway 2-amino-3-carboxymuconate semialdehyde - ? 288851 1.13.11.6 3-hydroxyanthranilate + O2 the enzyme employs loop dynamics to accommodate two substrates with disparate polarities 2-amino-3-carboxymuconate semialdehyde - ? 288851 1.13.11.6 4-ethyl-3-hydroxyanthranilate + O2 - 2-amino-3-carboxy-4-ethylmuconate semialdehyde - ? 288853 1.13.11.6 4-methyl-3-hydroxyanthranilate + O2 - 2-amino-3-carboxy-4-methylmuconate semialdehyde - ? 288852 1.13.11.6 4-propyl-3-hydroxyanthranilic acid + O2 - 2-amino-3-carboxy-4-propylmuconate semialdehyde - ? 288854 1.13.11.6 additional information no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates ? - ? 89 1.13.11.6 2-amino-3-hydroxybenzoic acid + O2 - 2,3-pyridinedicarboxylic acid + H2O intermediate 2-amino-3-carboxymuconic acid semialdehyde ? 402329 1.13.11.6 3-hydroxyanthranilate + O2 - 2-amino-3-carboxymuconate semialdehyde reacts spontaneously to quinolinic acid ? 288851 1.13.11.6 3-hydroxyanthranilate + O2 high selectivity for substrate 2-amino-3-carboxymuconate semialdehyde reacts spontaneously to quinolinic acid ? 288851 1.13.11.6 3-hydroxyanthranilate + O2 - 2-amino-3-carboxymuconate semialdehyde the enzymatic product subsequently cyclizes to quinolinate ? 288851