1.14.16.2 tyrosine 3-monooxygenase nucleus accumbens primary cell culture 688523 1.4.3.4 monoamine oxidase nucleus accumbens - 705454 1.4.3.5 pyridoxal 5'-phosphate synthase nucleus accumbens 5.2% of the activity in liver 655483 2.5.1.16 spermidine synthase nucleus accumbens highest levels of expression in nucleus accumbens, taenia tecta, cerebellar cortex, cerebral cortical layer I, hippocampus, hypothalamus, mesencephalic raphe nuclei, central and lateral amygdala, and the circumventricular organs 688510 2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase nucleus accumbens - 759407 2.7.1.107 diacylglycerol kinase (ATP) nucleus accumbens DGK-II 640375 2.7.1.137 phosphatidylinositol 3-kinase nucleus accumbens shell and core. Cocaine sensitization decreases PI3K activity in nuclear accumbens core. The changes are not normalized following the reversal of cocaine-sensitization. Cocaine-sensitized animals exhibited increased PI3K activity in the nuclear accumbens shell, and this increase is reversed by combined pergolide/ondansetron treatment. Selective enhancement of the PI3K activity in the NAc shell may be one of key alterations underlying the long-term cocaine sensitization 671736 3.1.1.7 acetylcholinesterase nucleus accumbens - 729516 3.4.11.7 glutamyl aminopeptidase nucleus accumbens highest activity 699650 3.4.21.26 prolyl oligopeptidase nucleus accumbens Core and Shell 694399 3.4.21.73 u-Plasminogen activator nucleus accumbens study on cocaine-induced conditioned-place preference in rats with bilateral intra-accumbens injections of uPA-expressing lentiviral vectors. Overexpression of uPA in the nucleus accumbens significantly augments cocaine-induced place preference. Reinstatement with a low dose of cocaine produces significantly greater preference to the cocaine-associated context. Inhibition of tuPA expression using doxycycline abolishes the augmented acquisition produced by overexpression of uPA but not the expression of the cocaine-induced conditioned-place preference. Cocaine-induced cocaine-induced conditioned-place preference and reinstatement may be dependent on active extracellular uPA 695974 3.6.1.13 ADP-ribose diphosphatase nucleus accumbens - 209946 4.1.1.15 glutamate decarboxylase nucleus accumbens - 699831