1.1.1.146 11beta-hydroxysteroid dehydrogenase melanoma cell - 760802 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) melanoma cell - 761332 1.1.1.42 isocitrate dehydrogenase (NADP+) melanoma cell - 711107 1.13.11.53 acireductone dioxygenase (Ni2+-requiring) melanoma cell - 764226 1.14.11.2 procollagen-proline 4-dioxygenase melanoma cell - 713361 1.14.14.18 heme oxygenase (biliverdin-producing) melanoma cell - 685815 1.14.14.18 heme oxygenase (biliverdin-producing) melanoma cell quantitative HO-1 expression analysis 687181 1.14.15.18 calcidiol 1-monooxygenase melanoma cell - 659811 1.14.16.4 tryptophan 5-monooxygenase melanoma cell - 658187 1.14.18.1 tyrosinase melanoma cell - 636339, 636340, 636355, 636360, 636374, 636398, 636401, 636402, 636412, 636416, 636417, 636418, 636422, 636425, 636430, 696686, 744671, 746188, 746346 1.5.1.3 dihydrofolate reductase melanoma cell DHFR is overexpressed in melanoma cells 705800 1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific) melanoma cell - -, 725514, 742841 1.6.3.1 NAD(P)H oxidase (H2O2-forming) melanoma cell - 742556 1.6.5.2 NAD(P)H dehydrogenase (quinone) melanoma cell - 746204 1.7.1.7 GMP reductase melanoma cell expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de novo biosynthesis of purine nucleotides, is downregulated in invasive stages of human melanoma. From 9 arbitrarily chosen human metastatic melanoma cell lines, GMPR is expressed in only one cell line 742245 1.8.1.9 thioredoxin-disulfide reductase melanoma cell amelanotic 394906 1.8.1.9 thioredoxin-disulfide reductase melanoma cell metastatic melanotic 394906, 394908, 394909, 394911 2.1.1.366 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase melanoma cell - 759353 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase melanoma cell - 705661 2.3.1.135 phosphatidylcholine-retinol O-acyltransferase melanoma cell diverse cell lines 715720 2.3.1.45 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase melanoma cell - 487039 2.3.1.45 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase melanoma cell sialic acid O-acetylation levels in different samples, overview 677235 2.3.1.B41 protein-long-chain fatty-acyl-lysine deacylase (NAD+) melanoma cell overexpression of SIRT6 in human melanoma tissues 756871 2.3.2.2 gamma-glutamyltransferase melanoma cell GGT-overexpression in melanoma cells is associated with resistance to oxidative stress produced by prooxidant agents such as hydrogen peroxide and ascorbic acid 686496 2.3.2.5 glutaminyl-peptide cyclotransferase melanoma cell - 759839 2.3.3.10 hydroxymethylglutaryl-CoA synthase melanoma cell although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells 757174 2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase melanoma cell GCNT3 is overexpressed in highly metastatic melanomas 759882 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase melanoma cell - 688812, 735724, 759316 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase melanoma cell - 735724 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase melanoma cell parental mouse melanoma cell S91 6neo 688812, 693954 2.4.1.274 glucosylceramide beta-1,4-galactosyltransferase melanoma cell - 736198 2.4.1.80 ceramide glucosyltransferase melanoma cell - 735591 2.4.1.90 N-acetyllactosamine synthase melanoma cell Bowes melanoma cell line 658123 2.4.1.92 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase melanoma cell high expression level 735601 2.4.2.12 nicotinamide phosphoribosyltransferase melanoma cell - 735872, 760200 2.4.2.28 S-methyl-5'-thioadenosine phosphorylase melanoma cell - 671628 2.4.2.28 S-methyl-5'-thioadenosine phosphorylase melanoma cell MTAP expression analysis 671628 2.4.2.28 S-methyl-5'-thioadenosine phosphorylase melanoma cell reduced activity due to hypermethylation of the promotor 637557 2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase melanoma cell - 637260 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase melanoma cell - 735601, 764085, 764812 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase melanoma cell - 736209, 764220 2.5.1.60 protein geranylgeranyltransferase type II melanoma cell significant overexpression of RabGGT-beta and Rab-GGT-alpha compared to normal tissue 658377 2.7.1.107 diacylglycerol kinase (ATP) melanoma cell - 672420 2.7.1.107 diacylglycerol kinase (ATP) melanoma cell expression of isoform diacylglycerol kinase alpha in several melanoma cell lines but not in noncancerous melanocytes 672420 2.7.1.147 ADP-specific glucose/glucosamine kinase melanoma cell - 723169 2.7.1.67 1-phosphatidylinositol 4-kinase melanoma cell - 721967 2.7.1.91 sphingosine kinase melanoma cell - 671356, 761980 2.7.10.2 non-specific protein-tyrosine kinase melanoma cell elevated levels of malignant cells 490359 2.7.11.1 non-specific serine/threonine protein kinase melanoma cell - 662601 2.7.11.20 elongation factor 2 kinase melanoma cell - 760309 2.7.11.22 cyclin-dependent kinase melanoma cell - 665840 2.7.11.26 tau-protein kinase melanoma cell - 740135 2.7.12.2 mitogen-activated protein kinase kinase melanoma cell - 740419 2.7.12.2 mitogen-activated protein kinase kinase melanoma cell choroidal from eyes, and cutaneous 665489 2.7.7.49 RNA-directed DNA polymerase melanoma cell - 692248 2.7.7.8 polyribonucleotide nucleotidyltransferase melanoma cell - 672972, 723628 2.7.8.27 sphingomyelin synthase melanoma cell isozymes SMS1 and SMS2 692991 2.8.1.2 3-mercaptopyruvate sulfurtransferase melanoma cell - 713731 3.1.1.64 retinoid isomerohydrolase melanoma cell malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters into 11-cis retinol, whereas melanocytes are not able to catalyze these reactions 715720 3.1.3.16 protein-serine/threonine phosphatase melanoma cell - 708789 3.1.3.36 phosphoinositide 5-phosphatase melanoma cell - 730456 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase melanoma cell minor splice isozyme PFKFB-4, major isozyme is PFKFB-3 666334 3.1.3.5 5'-nucleotidase melanoma cell - 677542 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase melanoma cell - 696397 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase melanoma cell secrets the mature ATX 713665 3.2.1.24 alpha-mannosidase melanoma cell - 665978 3.2.1.49 alpha-N-acetylgalactosaminidase melanoma cell cutaneous melanoma, specific enzymatic activity of serum alpha-N-acetylgalactosaminidase is significantly increased in stage III melanoma patients, but not in early stages 707963 3.2.2.29 thymine-DNA glycosylase melanoma cell - 706938, 751763 3.4.11.2 membrane alanyl aminopeptidase melanoma cell - 35865, 664466, 665112 3.4.13.9 Xaa-Pro dipeptidase melanoma cell high enzyme expression level 683964 3.4.13.9 Xaa-Pro dipeptidase melanoma cell high expression level 707010 3.4.13.9 Xaa-Pro dipeptidase melanoma cell higher expression of prolidase in tumor cells and particularly in melanoma cells 683061 3.4.14.5 dipeptidyl-peptidase IV melanoma cell - 703784 3.4.21.112 site-1 protease melanoma cell the enzyme SKI-1 is constitutively expressed in human pigment cells with higher SKI activity in seven out of eight melanoma cell lines compared with normal melanocytes, also detectable in tumor cells of melanoma metastases 732292 3.4.21.117 stratum corneum chymotryptic enzyme melanoma cell - 752892 3.4.21.5 thrombin melanoma cell - 717955 3.4.21.53 Endopeptidase La melanoma cell - 731618 3.4.21.61 Kexin melanoma cell - 732728 3.4.21.68 t-Plasminogen activator melanoma cell - 29577, 29592 3.4.21.68 t-Plasminogen activator melanoma cell cell-conditioned serum-free medium, Bowes 29587 3.4.21.75 Furin melanoma cell - 753199 3.4.21.B27 proprotein convertase 7 melanoma cell - 753199 3.4.22.1 cathepsin B melanoma cell - 681195, 753138 3.4.22.15 cathepsin L melanoma cell - 696091, 712921 3.4.22.15 cathepsin L melanoma cell cathepsin L activity was detected in the cell culture supernatant by lithium dodecyl sulfate gelatin zymography 667194 3.4.22.36 caspase-1 melanoma cell - 709153 3.4.22.38 cathepsin K melanoma cell immunostaining reveals strong catK expression in most primary melanomas and all cutaneous melanoma metastases. Melanocytic nevi also demonstrates catK expression, but it is less intense than in melanomas. Melanoma lines express both the pro- and the active form of catK 681252 3.4.22.43 cathepsin V melanoma cell - 752678 3.4.22.52 calpain-1 melanoma cell - 709406 3.4.22.54 calpain-3 melanoma cell - 708013 3.4.22.56 caspase-3 melanoma cell - 700600 3.4.22.56 caspase-3 melanoma cell expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview 698197 3.4.22.61 caspase-8 melanoma cell expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview 698197 3.4.24.16 neurolysin melanoma cell - -, 754898 3.4.24.23 matrilysin melanoma cell primary cutaneous and metastatic melanoma 683312 3.4.24.24 gelatinase A melanoma cell - 684054, 752865 3.4.24.56 insulysin melanoma cell - 668184 3.4.24.7 interstitial collagenase melanoma cell of invasive melanomas 683330 3.4.24.7 interstitial collagenase melanoma cell VMM5 cells, VMM12cells and VMM39. Constitutive overexpression of collagenase 1 is mediated by the ERK pathway in invasive melanoma cells 669246 3.4.24.80 membrane-type matrix metalloproteinase-1 melanoma cell - 734297