1.1.1.1 alcohol dehydrogenase aorta the activity of the class I ADH isoenzyme is significantly lower in the wall of aortic aneurysm than in healthy aorta 697802 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) aorta - 741244 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase aorta abdominal, expression level determination, especially in female aorta with mild atherosclerotic changes 668413 1.1.1.146 11beta-hydroxysteroid dehydrogenase aorta - 701239 1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) aorta - 286124 1.1.1.21 aldose reductase aorta - 286239, 668380, 711762, 711859 1.1.1.21 aldose reductase aorta vascular smooth muscle cells 669468 1.1.1.315 11-cis-retinol dehydrogenase aorta 26% mRNA expression of Rdh5 compared to liver 690797 1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+) aorta - 701239 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase aorta transgenic mouse 698045 1.11.1.6 catalase aorta - 655134 1.11.2.2 myeloperoxidase aorta atherosclerotic aorta 697307 1.13.11.33 arachidonate 15-lipoxygenase aorta - -, 684349, 742845 1.13.11.34 arachidonate 5-lipoxygenase aorta expression is not significantly different between diabetic and control rats. Activation of the 5-lipoxygenase previously reported in streptozotocin-induced diabetic rats can be explained by an augmented sensitivity to cysteinyl leukotrienes in the diabetic aorta 660412 1.14.11.2 procollagen-proline 4-dioxygenase aorta - 745084 1.14.11.2 procollagen-proline 4-dioxygenase aorta embryo 439200 1.14.11.2 procollagen-proline 4-dioxygenase aorta rat abdominal aortas -, 745084 1.14.11.4 procollagen-lysine 5-dioxygenase aorta expression only of LH2long 659845 1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase aorta of control and hyperglycemic mice 697557 1.14.12.17 nitric oxide dioxygenase aorta endothelial cells 658747 1.14.13.39 nitric-oxide synthase (NADPH) aorta - 745938 1.14.13.39 nitric-oxide synthase (NADPH) aorta thoracic, muscle 685867 1.14.14.18 heme oxygenase (biliverdin-producing) aorta - 688237 1.15.1.1 superoxide dismutase aorta - 685864 1.17.3.2 xanthine oxidase aorta - 688155, 689994 1.17.3.2 xanthine oxidase aorta lower enzyme activity compared to vena cava 684354 1.17.3.2 xanthine oxidase aorta smooth muscle cells 688146 1.17.3.2 xanthine oxidase aorta wall 686890 1.2.1.3 aldehyde dehydrogenase (NAD+) aorta - 711625 1.2.1.5 aldehyde dehydrogenase [NAD(P)+] aorta - 688446 1.2.1.94 farnesal dehydrogenase aorta - 717961 1.2.3.1 aldehyde oxidase aorta - 693075 1.4.3.13 protein-lysine 6-oxidase aorta - 391736, 391737, 391739, 391742, 655021, 659558, 675286, 684802, 695968, 699875, 713462, 724520 1.4.3.13 protein-lysine 6-oxidase aorta co-localization of LOX and LOXL 659751 1.4.3.13 protein-lysine 6-oxidase aorta different spatial and temporal expression of LOX and LOXL1 during growth and aging, expression analysis of LOXL1 and LOX in the aorta during the development, growth, and aging of LOU rats, overview 701156 1.4.3.13 protein-lysine 6-oxidase aorta LOX, LOXL, LOXL3, low expression level of LOXL2 658189 1.4.3.21 primary-amine oxidase aorta - 687449, 688603 1.4.3.5 pyridoxal 5'-phosphate synthase aorta 1.2% of the activity in liver 655483 1.5.1.34 6,7-dihydropteridine reductase aorta - 741864 1.6.2.4 NADPH-hemoprotein reductase aorta - -, 288616 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta - 685975, 711166, 711763, 713366 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta abdominal aortic endothelial cells 686418 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta aortas of transgenic rats harboring the mouse renin transgene exhibit greater NADPH oxidase activity, reactive oxygen species levels, C-reactive protein, tumor necrosis factor-alpha expression, apoptosis, and wall thickness, which are significantly attenuated by in vivo treatment with angiotensin type 1 receptor blockade by valsartan or the superoxide dismutase/catalase mimetic tempol 687049 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta aortic ring 684351 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta aortic rings 685982 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta cultured aortic smooth muscle cell 684269 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta Exposure of mouse aortic rings to hypoxia/reoxygenation significantly increases vessel outgrowth, whereas pharmacological inhibition of NADPH oxidase or genetic deletion of the NADPH oxidase subunit, p47phox significantly suppresses these changes. Increases in myocardial serine-threonine kinase Akt and ERK1/2 activation and vascular endothelial growth factor expression are markedly blunted in the subunit p47phox-deficient mouse subjected to myocardial ischemia-reperfusion compared with the wild-type mouse 684345 1.6.3.1 NAD(P)H oxidase (H2O2-forming) aorta hemin treatment increases hemin oxidase-1 expression and activity in aorta and kidney of apolipoprotein E-deficient mice and significantly reduces both NADPH oxidase activity and superoxide generation in situ. Effects are reversed by tin protoporphyrin-IX and are not associated with changes in isoforms Nox2 or Nox4 protein levels. Inhibition of NADPH oxidase activity by hemin in the aorta is mimicked by bilirubin in vitro 687050 1.8.4.12 peptide-methionine (R)-S-oxide reductase aorta - 686598 1.8.4.2 protein-disulfide reductase (glutathione) aorta - 394828 1.8.5.8 eukaryotic sulfide quinone oxidoreductase aorta - 764408 2.1.1.6 catechol O-methyltransferase aorta - 686194 2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase aorta - 485560 2.3.1.149 Platelet-activating factor acetyltransferase aorta immunohistochemistry shows PAF-AH expression in the intima and in the media of the aorta 693520 2.3.1.26 sterol O-acyltransferase aorta - 486688, 486698, 486703 2.3.1.26 sterol O-acyltransferase aorta 41fold induction of activity after 60 days of cholesterol feeding 486683 2.3.1.26 sterol O-acyltransferase aorta atheroschlerotic tissue 486688, 486703 2.3.1.26 sterol O-acyltransferase aorta extremely low activity 486704 2.4.1.131 GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase aorta intimal layer 638569 2.4.1.255 protein O-GlcNAc transferase aorta - 703977 2.4.1.255 protein O-GlcNAc transferase aorta distribution of OGTase in the aorta is examined by immunofluorescence microscopy 701898 2.4.1.87 N-acetyllactosaminide 3-alpha-galactosyltransferase aorta - 489479 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase aorta atherosclerotic and normal aorta 705676 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase aorta atherosclerotic aortic intima 658140 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase aorta level of GM3 synthase in membrane-fractions isolated from the atherosclerotic intima are higher compared to those in non-dieased arterial tissue 657703 2.5.1.57 N-acylneuraminate-9-phosphate synthase aorta - 637818 2.6.1.42 branched-chain-amino-acid transaminase aorta endothelial cells 640023 2.7.1.127 inositol-trisphosphate 3-kinase aorta smooth muscle 640742, 640743 2.7.1.52 fucokinase aorta - 641674, 661521, 703298 2.7.10.1 receptor protein-tyrosine kinase aorta smooth muscle 660727 2.7.10.2 non-specific protein-tyrosine kinase aorta endothelial cells, PYK2 673110 2.7.11.10 IkappaB kinase aorta - 760461 2.7.11.12 cGMP-dependent protein kinase aorta - 662462, 674575, 704619, 721982, 722222 2.7.11.12 cGMP-dependent protein kinase aorta aortic homogenate, neointima 721982 2.7.11.12 cGMP-dependent protein kinase aorta high expression of isozymes PKG-1alpha and PKG-1beta 660671 2.7.11.12 cGMP-dependent protein kinase aorta smooth muscle 661575 2.7.11.13 protein kinase C aorta - 662054 2.7.11.16 G-protein-coupled receptor kinase aorta - 491168 2.7.11.17 Ca2+/calmodulin-dependent protein kinase aorta - 491257, 491258, 640685, 671227 2.7.11.17 Ca2+/calmodulin-dependent protein kinase aorta smooth muscle 640688 2.7.11.18 myosin-light-chain kinase aorta - 491268, 661664, 687732 2.7.11.18 myosin-light-chain kinase aorta thoracic 640625 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase aorta - -, 644987, 693032, 704431 2.7.3.2 creatine kinase aorta - 642371 2.7.7.23 UDP-N-acetylglucosamine diphosphorylase aorta - 643065 2.7.7.30 fucose-1-phosphate guanylyltransferase aorta - 645224 2.7.8.15 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase aorta - 645351, 645353 2.7.8.27 sphingomyelin synthase aorta - 668729 2.7.8.27 sphingomyelin synthase aorta high expression of SMS1 mRNA 668729 2.8.1.2 3-mercaptopyruvate sulfurtransferase aorta 3MST and cytosolic and mitochondrial cysteine aminotransferases are localized to endothelial cells of the thoracic aorta 704359 2.8.2.15 steroid sulfotransferase aorta aortic smooth muscle cell line CRL-1999 645740 2.8.2.4 estrone sulfotransferase aorta female aortic smooth muscle cell line CRL-1999 cell 645740 2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase aorta - -, 762448 3.1.1.13 sterol esterase aorta - 133849 3.1.1.34 lipoprotein lipase aorta aortic endothelial cells 665649 3.1.1.34 lipoprotein lipase aorta highest expression is found in aorta 690660 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase aorta atherogenic aorta 693520 3.1.2.2 palmitoyl-CoA hydrolase aorta - 646158 3.1.2.20 acyl-CoA hydrolase aorta - 646158 3.1.3.1 alkaline phosphatase aorta - 693930