1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase RINm5F cell 100 nM 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid upregulates phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA and protein expressions. Under persistent oxidative stress the formation of 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid and the 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid-induced upregulation of PHGPx constitute a compensatory defense response to protect the vitality and functionality of the cell 689838 2.7.1.127 inositol-trisphosphate 3-kinase RINm5F cell insulin-secreting 640739 3.6.5.1 heterotrimeric G-protein GTPase RINm5F cell - 654813