1.14.11.16	peptide-aspartate beta-dioxygenase	hepatoma cell line	-	742626, 743379, 743882	
1.14.11.16	peptide-aspartate beta-dioxygenase	hepatoma cell line	increased expression of aspartate beta-hydroxylase in hepatocellular carcinoma tissues is associated with tumor invasiveness and a worse prognosis. Aspartate beta-hydroxylase overexpression in hepatocellular carcinoma tissues is correlated with decreased copy numbers of displacement loop (D-loop) and NADH dehydrogenase subunit 1 and enhanced D-loop mutation, suggesting the disrupted mitochondrial DNA (mtDNA) stability. The reduced mtDNA copy numbers are associated with aggressive clinicopathological features of hepatocellular carcinoma. The loss of mtDNA integrity induced by enforced expression of Aspartate beta-hydroxylase is accompanied with mitochondrial dysfunction, which is characterized by the aberrant mitochondrial membrane potential, decreased ATP generation and enhanced reactive oxygen species. The enzyme interacts with histone H2A member X. Overexpression of aspartate beta-hydroxylase diminishes the interaction between histone H2A member X and mitochondrial transcription factor A (mtTFA), an important DNA-binding protein for mtDNA replication, which then reduced the binding of mtTFA to D-loop region. Overexpression of aspartate beta-hydroxylase disrupts the mtDNA integrity through H2AX-mtTFA signal, thereby affecting mitochondrial functions in hepatocellular carcinoma	743376	
1.14.11.18	phytanoyl-CoA dioxygenase	hepatoma cell line	-	285272	
1.14.15.3	alkane 1-monooxygenase	hepatoma cell line	-	673653	
1.4.3.3	D-amino-acid oxidase	hepatoma cell line	101L cell	697313	
1.5.1.2	pyrroline-5-carboxylate reductase	hepatoma cell line	full-length sequence is amplified from a hepatoma cell line cDNA library	676969	
2.1.1.5	betaine-homocysteine S-methyltransferase	hepatoma cell line	hyperosmolarity (405 mosmol/l) suppresses Bhmt mRNA expression whereas hypoosmotic (205 mosmol/l) conditions induce Bhmt mRNA expression. Like hyperosmotic NaCl, hyperosmotic raffinose but not hyperosmotic urea suppresses Bhmt mRNA expression. Osmosensitivity of Bhmt mRNA expression is impaired by inhibitors of tyrosine kinases and cyclic nucleotide-dependent kinases	671242	
2.4.1.144	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	hepatoma cell line	7721 cell	638226	
2.5.1.26	alkylglycerone-phosphate synthase	hepatoma cell line	the enzyme is upregulated in multiple types of cancer cells and primary tumors	737578	
2.7.1.1	hexokinase	hepatoma cell line	AS-30D, highly glycolytic tumor cells	640210	
2.7.1.30	glycerol kinase	hepatoma cell line	HaIIE (ATCC)	705749	
2.7.1.32	choline kinase	hepatoma cell line	Hepa-1	685337	
2.7.1.36	mevalonate kinase	hepatoma cell line	cell line PLC/PRF/5	641446	
2.7.10.2	non-specific protein-tyrosine kinase	hepatoma cell line	PLC cell	691651	
2.7.11.2	[pyruvate dehydrogenase (acetyl-transferring)] kinase	hepatoma cell line	The human liver cancer cell line HepG3B was obtained from the cell bank of the Institute of Biochemistry and Cell Biology	761575	
2.7.4.6	nucleoside-diphosphate kinase	hepatoma cell line	Novikoff	642661	
2.8.3.5	3-oxoacid CoA-transferase	hepatoma cell line	H1e human hepatoma cell line, but no detection in normal hepatocytes, HepG2 hepatoma cells and liver tissues	695186	
3.1.4.1	phosphodiesterase I	hepatoma cell line	PLC/ PRF/5 human hepatoma	208356	
3.2.1.207	mannosyl-oligosaccharide alpha-1,3-glucosidase	hepatoma cell line	-	136899	
3.4.21.68	t-Plasminogen activator	hepatoma cell line	transformed	29575	
3.4.24.35	gelatinase B	hepatoma cell line	-	697085	
3.5.1.114	N-acyl-aromatic-L-amino acid amidohydrolase	hepatoma cell line	AA3 expression in the hepatocellular carcinoma cell lines is 5 to 20 times greater than in normal primary hepatocytes	754228	
4.1.1.22	histidine decarboxylase	hepatoma cell line	-	693822	
4.1.1.32	phosphoenolpyruvate carboxykinase (GTP)	hepatoma cell line	H4IIEC3 cells, mRNA is 5-10fold elevated in cells cultured at high density compared to low density, KRC-7 cells, an H4IIEC3 subclone, are much more sensitive to growth arrest than its parental cell line	649586	
4.1.1.32	phosphoenolpyruvate carboxykinase (GTP)	hepatoma cell line	Reuber H365 hepatoma cells	4364	
4.2.1.1	carbonic anhydrase	hepatoma cell line	-	700140	
6.3.5.2	GMP synthase (glutamine-hydrolysing)	hepatoma cell line	-	1384