1.1.1.1 alcohol dehydrogenase heart - 285604 1.1.1.10 L-xylulose reductase heart - 656049 1.1.1.10 L-xylulose reductase heart low expression level 656049 1.1.1.101 acylglycerone-phosphate reductase heart - 285684 1.1.1.102 3-dehydrosphinganine reductase heart high expression 656256 1.1.1.102 3-dehydrosphinganine reductase heart low level of expression 656256 1.1.1.103 L-threonine 3-dehydrogenase heart - 285720, 655125 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) heart strong mRNA expression 692959 1.1.1.112 indanol dehydrogenase heart - 285758, 285762 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) heart - 285912, 285918 1.1.1.146 11beta-hydroxysteroid dehydrogenase heart - 760868 1.1.1.146 11beta-hydroxysteroid dehydrogenase heart coexpression of 121beta-HSD1 with hexose-6-phosphate dehydrogenase 686419 1.1.1.146 11beta-hydroxysteroid dehydrogenase heart low level of expression, low activity 693886 1.1.1.146 11beta-hydroxysteroid dehydrogenase heart of normotensive and hypertensive rats, the latter are hyperthrophied and fibrotic and have structural alterations in the coronary circulation, expression of isozymes 11beta-HSD1 and 11beta-HSD2, overview 670034 1.1.1.146 11beta-hydroxysteroid dehydrogenase heart weak expression 693886 1.1.1.149 20alpha-hydroxysteroid dehydrogenase heart moderate expression rate of AKR1C23 669908 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) heart - 286013, 286024 1.1.1.162 erythrulose reductase heart - 286086, 286091 1.1.1.177 glycerol-3-phosphate 1-dehydrogenase (NADP+) heart myocardium, intermediate activity 286119 1.1.1.184 carbonyl reductase (NADPH) heart - 347766, 656568, 667076, 668238, 688022, 690091, 697582, 740807 1.1.1.184 carbonyl reductase (NADPH) heart high expression level 655212 1.1.1.184 carbonyl reductase (NADPH) heart low expression of CBR3 697582 1.1.1.188 prostaglandin-F synthase heart - 389464, 654851, 661605, 687797 1.1.1.188 prostaglandin-F synthase heart high activity 687797 1.1.1.189 prostaglandin-E2 9-reductase heart - 389477, 654851, 657211 1.1.1.2 alcohol dehydrogenase (NADP+) heart - -, 286168, 286182, 286183, 286184, 286204 1.1.1.2 alcohol dehydrogenase (NADP+) heart muscle 286183 1.1.1.21 aldose reductase heart - 286240, 655525, 667205, 668540, 697266, 738005, 738593, 761409 1.1.1.21 aldose reductase heart cultured cardiomyocyte 656165 1.1.1.21 aldose reductase heart healthy and ischemic, left ventricular tissue 669455 1.1.1.21 aldose reductase heart ischemic heart 669455 1.1.1.21 aldose reductase heart very low enzyme expression and activity in mice 667205 1.1.1.21 aldose reductase heart with myocardial ischemia-reperfusion injuries 655528 1.1.1.21 aldose reductase heart with rapid left ventricular pacing 654170 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase heart - -, 286269, 740438, 740641, 741474 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase heart adult and fetal, strong expression in the myocard tissue, but not in vessels 670476 1.1.1.218 morphine 6-dehydrogenase heart in female hamsters 740637 1.1.1.225 chlordecone reductase heart - 286316 1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) heart in female hamsters 740637 1.1.1.27 L-lactate dehydrogenase heart - 286460, 286464, 286471, 655742, 670394, 670846, 685618, 695196, 696769, 696774, 698332, 711801, 712102, 762363 1.1.1.27 L-lactate dehydrogenase heart contains a heart type homotetrameric enzyme, H4 740001 1.1.1.27 L-lactate dehydrogenase heart H-type isozyme -, 685502 1.1.1.27 L-lactate dehydrogenase heart heart-type isozyme 686014 1.1.1.27 L-lactate dehydrogenase heart in patients with tubercular pyothorax, decrease in heart specific aerobic LDH-1 (6fold), LDH-2 (2fold) and LDH-3 (1.5fold) 698228 1.1.1.28 D-lactate dehydrogenase heart - 286488 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase heart - -, 762615, 762934 1.1.1.30 3-hydroxybutyrate dehydrogenase heart - 286512, 286513, 286514, 286516, 286517, 286519, 286520, 286521, 286525, 286528, 286530, 286535, 286536, 286538, 286540, 286542 1.1.1.300 NADP-retinol dehydrogenase heart high expression level 686690 1.1.1.300 NADP-retinol dehydrogenase heart high mRNA expression 690876 1.1.1.31 3-hydroxyisobutyrate dehydrogenase heart - 286549, 722472 1.1.1.315 11-cis-retinol dehydrogenase heart 26% mRNA expression of Rdh5 compared to liver 690797 1.1.1.315 11-cis-retinol dehydrogenase heart low mRNA expression 692939 1.1.1.315 11-cis-retinol dehydrogenase heart the 3 kb isoform is the most abundant one 692332 1.1.1.32 mevaldate reductase heart - 286555 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) heart high expression level 722328 1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+) heart - 287843 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase heart - 286269, 286588, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 33713, 673340, 673530, 723558 1.1.1.36 acetoacetyl-CoA reductase heart very low expression of isozymes AKR1B15.1 and AKR1B15.2 740743 1.1.1.37 malate dehydrogenase heart - 286626, 286629, 286630, 286632, 286633, 286635, 286636, 286637, 286638, 286639, 286640, 286641, 286645, 286646, 286647, 286650, 286651, 286658, 286660, 286661, 286662, 286664, 286665, 286672, 286673, 286674, 656883, 667442, 696067, 711909, 712915, 740165, 740166, 740359 1.1.1.39 malate dehydrogenase (decarboxylating) heart - 286715 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) heart - 760901 1.1.1.41 isocitrate dehydrogenase (NAD+) heart - 286749, 286751, 286752, 286755, 286759, 286760, 286762, 286765, 286767, 286769, 286775, 741458 1.1.1.42 isocitrate dehydrogenase (NADP+) heart - 286749, 286782, 286783, 286785, 286786, 286797, 654649, 656093, 656180, 656431, 669307, 670334, 698056, 740117 1.1.1.42 isocitrate dehydrogenase (NADP+) heart increase of enzyme activity in the cytosol and mitochondria of ischemic heart 670236 1.1.1.42 isocitrate dehydrogenase (NADP+) heart regulation of enzyme during heart ischemia. Ischemia results in increase in enzyme activity, enzyme from ischemic heart mitochondria demonstrates higher activation energy and lower thermal stability and differs in KM-value and regulation 670236 1.1.1.43 phosphogluconate 2-dehydrogenase heart - 688042 1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) heart - 286839, 286903 1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) heart low activity in female and male rats, constant at age 2 months to age 9 months 655737 1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) heart nicotine has no effect on enzyme activity 688042 1.1.1.45 L-gulonate 3-dehydrogenase heart - 286908 1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+) heart - 675105, 697523 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) heart - 389547 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase heart in female hamsters 740637 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase heart isozyme 17beta-HSD8 675476 1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase heart - 688455, 698084 1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase heart weak expression of subunit A, weak expression of subunit B 762606 1.1.1.55 lactaldehyde reductase (NADPH) heart - 389564 1.1.1.59 3-hydroxypropionate dehydrogenase heart - 287142 1.1.1.62 17beta-estradiol 17-dehydrogenase heart - 688956, 740849 1.1.1.62 17beta-estradiol 17-dehydrogenase heart low mRNA expression 688007 1.1.1.62 17beta-estradiol 17-dehydrogenase heart moderate expression 685803 1.1.1.62 17beta-estradiol 17-dehydrogenase heart very low expression of isozymes AKR1B15.1 and AKR1B15.2 740743 1.1.1.64 testosterone 17beta-dehydrogenase (NADP+) heart expression in male, hardly detectable in female 669905 1.1.1.66 omega-hydroxydecanoate dehydrogenase heart - 207967 1.1.1.71 alcohol dehydrogenase [NAD(P)+] heart - 655563 1.1.1.75 (R)-aminopropanol dehydrogenase heart - 287301 1.1.1.77 lactaldehyde reductase heart - 287308 1.1.1.78 methylglyoxal reductase (NADH) heart - 207968 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) heart very low expression level -, 712993 1.1.1.96 diiodophenylpyruvate reductase heart - 287552, 287553, 287554 1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+) heart of normotensive and hypertensive rats, the latter are hyperthrophied and fibrotic and have structural alterations in the coronary circulation, expression of isozymes 11beta-HSD1 and 11beta-HSD2, overview 670034 1.1.3.8 L-gulonolactone oxidase heart - 636311 1.1.5.13 (S)-2-hydroxyglutarate dehydrogenase heart - 755232 1.1.99.1 choline dehydrogenase heart - 711962 1.1.99.2 L-2-hydroxyglutarate dehydrogenase heart low level 657168 1.1.99.24 hydroxyacid-oxoacid transhydrogenase heart highest activity in liver and kidney and an intermediate activity in heart 664967 1.1.99.24 hydroxyacid-oxoacid transhydrogenase heart low enzyme activity 664967 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone) heart - 657888, 658430, 659111 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase heart - 394864, 394865, 394867, 394868, 394869, 394870, 394871, 394881, 671327, 673845, 674370, 674598, 686888, 697470 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase heart parenchym 688464 1.11.1.16 versatile peroxidase heart - 764524 1.11.1.20 prostamide/prostaglandin F2alpha synthase heart - 687797 1.11.1.20 prostamide/prostaglandin F2alpha synthase heart activity is the highest in spinal cord and brain followed by thymus, adrenal gland, heart, and genital organs 687797 1.11.1.24 thioredoxin-dependent peroxiredoxin heart - 686285, 700109, 725050 1.11.1.24 thioredoxin-dependent peroxiredoxin heart 0.0013 mg Prx I per mg of soluble protein Prx I, 0.002 mg Prx II per mg of soluble protein, 0.0033 mg Prx III per mg of soluble protein, 0.0005 mg Prx V per mg of soluble protein and 0.0003 mg Prx VI per mg of soluble protein 655756 1.11.1.5 cytochrome-c peroxidase heart - 672298, 672308, 672309 1.11.1.6 catalase heart - 725156, 725932 1.11.1.6 catalase heart activity increased significantly in the diazinon treated group compared with the control group 672966 1.11.1.6 catalase heart highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart 744948 1.11.1.7 peroxidase heart - 698048 1.11.1.7 peroxidase heart thioreoxin peroxidase 439745 1.11.1.7 peroxidase heart VPO2 is highly expressed in heart 698048 1.11.1.9 glutathione peroxidase heart - 658792, 695410 1.11.1.9 glutathione peroxidase heart highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart 744948 1.11.1.9 glutathione peroxidase heart highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain 724102 1.11.1.9 glutathione peroxidase heart highest mRNA expression in pyloric ceca, followed by brain, heart and liver 724102 1.11.1.9 glutathione peroxidase heart overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart 671245 1.11.1.9 glutathione peroxidase heart weak expression of pGPx 672988 1.13.11.19 cysteamine dioxygenase heart - 396418 1.13.11.19 cysteamine dioxygenase heart high activity 687595 1.13.11.31 arachidonate 12-lipoxygenase heart - -, 704901, 741573 1.13.11.31 arachidonate 12-lipoxygenase heart expression of 12/15-LOX pathway is upregulated in the diabetic heart -, 742346 1.13.11.33 arachidonate 15-lipoxygenase heart - -, 701636, 726871 1.13.11.33 arachidonate 15-lipoxygenase heart expression of 12/15-LOX pathway is upregulated in the diabetic heart -, 742346 1.13.11.34 arachidonate 5-lipoxygenase heart - 686557, 742314 1.13.11.5 homogentisate 1,2-dioxygenase heart expression of HGO gene 439388 1.13.11.52 indoleamine 2,3-dioxygenase heart - 665457 1.13.11.63 beta-carotene 15,15'-dioxygenase heart - 744160 1.13.11.63 beta-carotene 15,15'-dioxygenase heart beta-carotene-15,15'-dioxygenase (BCO1) protein is not expressed in adult hearts of male wild-type mice 743991 1.13.11.71 carotenoid-9',10'-cleaving dioxygenase heart - -, 744160 1.13.11.71 carotenoid-9',10'-cleaving dioxygenase heart low abundance of mRNA 719806 1.14.11.1 gamma-butyrobetaine dioxygenase heart - 439296, 676337, 697453, 699163 1.14.11.16 peptide-aspartate beta-dioxygenase heart - 439251 1.14.11.2 procollagen-proline 4-dioxygenase heart - 439239, 439242, 439243, 659235 1.14.11.2 procollagen-proline 4-dioxygenase heart embryo 439200 1.14.11.2 procollagen-proline 4-dioxygenase heart expression of enzyme alpha-I and alpha-II subunit mRNAs 439242 1.14.11.2 procollagen-proline 4-dioxygenase heart expression of enzyme alpha-I and alpha-II subunits mRNAs 439239 1.14.11.2 procollagen-proline 4-dioxygenase heart the type I enzyme is the main enzyme form 439243 1.14.11.29 hypoxia-inducible factor-proline dioxygenase heart - 741826 1.14.11.29 hypoxia-inducible factor-proline dioxygenase heart expression level of of HIF-P4H-3 mRNA is highest in the adult heart, brain, placenta, lung, and skeletal muscle and in the fetal heart, spleen, and skeletal muscle 659235 1.14.11.29 hypoxia-inducible factor-proline dioxygenase heart the levels of HIF-P4H-2 mRNA expression is highest in the adult heart, brain, lung, and liver and in the fetal brain, heart, spleen, and skeletal muscle 659235 1.14.11.4 procollagen-lysine 5-dioxygenase heart - 657744, 659548, 675031, 675766, 724792 1.14.11.65 [histone H3]-dimethyl-L-lysine9 demethylase heart 3.3fold increase in mRNA after 6 h of hypoxia 684929 1.14.11.7 procollagen-proline 3-dioxygenase heart isozyme P3H1 697189 1.14.11.7 procollagen-proline 3-dioxygenase heart isozyme P3H2 697189 1.14.11.7 procollagen-proline 3-dioxygenase heart isozyme P3H3 697189 1.14.11.8 trimethyllysine dioxygenase heart - 671302, 675029 1.14.13.39 nitric-oxide synthase (NADPH) heart - 671278, 744948 1.14.13.39 nitric-oxide synthase (NADPH) heart eNOS 687358 1.14.13.8 flavin-containing monooxygenase heart - 673313 1.14.14.154 sterol 14alpha-demethylase heart - 673147 1.14.14.18 heme oxygenase (biliverdin-producing) heart - 438244, 438257, 674063 1.14.14.19 steroid 17alpha-monooxygenase heart - 705401 1.14.14.24 vitamin D 25-hydroxylase heart low expression 717769 1.14.14.32 17alpha-hydroxyprogesterone deacetylase heart - 734569 1.14.14.94 leukotriene-B4 20-monooxygenase heart CYP4F11 660409 1.14.15.15 cholestanetriol 26-monooxygenase heart - 736710 1.14.15.16 vitamin D3 24-hydroxylase heart - 714836 1.14.15.18 calcidiol 1-monooxygenase heart - 737985 1.14.15.3 alkane 1-monooxygenase heart - 671219 1.14.15.4 steroid 11beta-monooxygenase heart - 686286 1.14.15.4 steroid 11beta-monooxygenase heart cardiac tissue from several rat models of cardiovascular pathology, low constitutive expression, which seems to be of no physiologic relevance 673345 1.14.16.2 tyrosine 3-monooxygenase heart - 438686, 701155, 745402 1.14.16.2 tyrosine 3-monooxygenase heart 2fold activity under cold stress. Injection of the angiotensin converting enzyme inhibitor enalapril malate prevented the increase of tyrosine hydroxylase under cold stress 672960 1.14.16.2 tyrosine 3-monooxygenase heart increase in tyrosine hydroxylase protein levels and tyrosine hydroxylase enzyme activity might contribute to the enhanced noradrenergic activity in the heart in response to morphine withdrawam 658658 1.14.16.4 tryptophan 5-monooxygenase heart low levels of TPH-2 705929 1.14.16.5 alkylglycerol monooxygenase heart - 688220 1.14.17.1 dopamine beta-monooxygenase heart - 727633 1.14.17.1 dopamine beta-monooxygenase heart lowest level of all tissues 702945 1.14.17.3 peptidylglycine monooxygenase heart - 438586, 648703, 657678, 658458 1.14.17.3 peptidylglycine monooxygenase heart atrium 438579, 438583 1.14.17.3 peptidylglycine monooxygenase heart myoblast, H9c2 cells 438588 1.14.17.3 peptidylglycine monooxygenase heart predominantly membrane-associated, bifunctional enzyme 438583 1.14.17.3 peptidylglycine monooxygenase heart ventricle 438583 1.14.18.2 CMP-N-acetylneuraminate monooxygenase heart weak activity 639329 1.14.19.1 stearoyl-CoA 9-desaturase heart - 688769, 714663 1.14.19.1 stearoyl-CoA 9-desaturase heart exclusively expressed in heart, no repression by dietary polyunsaturated fatty acids, induction in SCD1-deficient animals 659244 1.14.19.1 stearoyl-CoA 9-desaturase heart isoforms SCD-1 and SCD-4 695472 1.14.19.1 stearoyl-CoA 9-desaturase heart isozyme SCD1, SCD2, and SCD4 684339 1.14.19.1 stearoyl-CoA 9-desaturase heart isozyme SCD4 is expressed mainly in the heart 746542 1.14.19.1 stearoyl-CoA 9-desaturase heart low expression level of isozyme SCD1 688769 1.14.19.1 stearoyl-CoA 9-desaturase heart SCD4 isoform 673285 1.14.19.3 acyl-CoA 6-desaturase heart - 659836 1.14.19.30 acyl-lipid (8-3)-desaturase heart - 746201 1.14.19.30 acyl-lipid (8-3)-desaturase heart most abundant 734131 1.14.19.44 acyl-CoA (8-3)-desaturase heart most abundant in the heart 734131 1.14.19.47 acyl-lipid (9-3)-desaturase heart highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen 746261 1.14.99.38 cholesterol 25-monooxygenase heart - 658159, 700999, 727109 1.14.99.60 3-demethoxyubiquinol 3-hydroxylase heart COQ7 is highly expressed in tissues with high energy demand such as heart, muscle, liver, and kidney 746956 1.15.1.1 superoxide dismutase heart - 438089, 727563, 744746, 746564 1.15.1.1 superoxide dismutase heart Cu,Zn-SOD, in vessels, including endothelium -, 438181 1.15.1.1 superoxide dismutase heart cytoplasmic manganese SOD 745093 1.15.1.1 superoxide dismutase heart Mn-SOD, endothelium -, 438181 1.16.1.8 [methionine synthase] reductase heart in vivo quantitative real-time PCR analysis of MTRR mRNA in cardiac tissue samples from congenital heart disease patients, overview 727334 1.17.1.4 xanthine dehydrogenase heart - 644557, 644558 1.17.1.4 xanthine dehydrogenase heart high rate of dehydrogenase activity 644557, 644558 1.17.1.4 xanthine dehydrogenase heart low enzyme activity 706471 1.17.1.4 xanthine dehydrogenase heart only oxidase type O form 644582 1.17.3.2 xanthine oxidase heart - 685983, 687898 1.17.3.2 xanthine oxidase heart enzyme expression is increased in the failing heart 688764 1.17.3.2 xanthine oxidase heart xanthine oxidase mediated nitrite reduction can be a source of NO in heart tissue under conditions of tissue normoxia, and it is further increased with mild hypoxia 659326 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) heart fetal and adult 671387 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) heart measurement of allelic mRNA expression 685791 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) heart the enzyme is upregulated in fetal heart and in ventricular aneurysm tissue 675907 1.2.1.104 pyruvate dehydrogenase system heart - 348927, 348930, 348941, 656269, 656580, 656612, 672469, 695486, 695494, 759082, 759453, 759561, 94881 1.2.1.104 pyruvate dehydrogenase system heart overall reaction activities of the PDH and OGDH complexes are very high, in order of heart > abdominal skeletal muscle > kidney. Their gene expression is strongest in heart and skeletal muscle 759549 1.2.1.105 2-oxoglutarate dehydrogenase system heart - 348910, 348914, 349005, 349014, 349020, 349021, 349023, 349026, 349027, 349028, 349033, 656580, 656591, 672280, 676088, 676319, 685238, 758747, 759437, 759561 1.2.1.105 2-oxoglutarate dehydrogenase system heart overall reaction activities of the PDH and OGDH complexes are very high, in order of heart > abdominal skeletal muscle > kidney. Their gene expression is strongest in heart and skeletal muscle 759549 1.2.1.107 glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring) heart - 762496 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) heart - -, 287911, 287932, 674503, 688791, 742889 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) heart moderate expression 698019 1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating) heart - 690142 1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+) heart - 288174 1.2.1.25 branched-chain alpha-keto acid dehydrogenase system heart - 762596, 763515 1.2.1.3 aldehyde dehydrogenase (NAD+) heart - 655948, 690142, 711691, 712435 1.2.1.3 aldehyde dehydrogenase (NAD+) heart highly expressed 673291 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase heart - 675897, 690142 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase heart high expression 288202 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase heart mRNA expression 675897 1.2.1.36 retinal dehydrogenase heart - 673325, 690142 1.2.1.36 retinal dehydrogenase heart abundant 686690 1.2.1.41 glutamate-5-semialdehyde dehydrogenase heart - 690142 1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase heart - 671302, 690142, 743576, 762831 1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase heart enzyme TMABA-DH colocalizes with myosin light chains in cardiac myocytes 743576 1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase heart low activity 671302 1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase heart medium activity 671302 1.2.1.48 long-chain-aldehyde dehydrogenase heart low activity 725656 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+) heart - 288148 1.2.1.5 aldehyde dehydrogenase [NAD(P)+] heart - 690142 1.2.1.8 betaine-aldehyde dehydrogenase heart - 390346, 390363 1.2.1.84 alcohol-forming fatty acyl-CoA reductase heart - 656242 1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase heart northern blot analysis 392064 1.2.3.1 aldehyde oxidase heart - 390422, 674600, 691701, 693075 1.2.3.1 aldehyde oxidase heart weak expression 692569 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring) heart - 348935, 348955, 348974, 710839, 712851, 759082 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring) heart from 4-, and 24- to 28-months-old male F344 rats 654462 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) heart - 349011, 349013, 349041, 654699, 656595, 740480, 763067 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) heart - 349060, 349070, 349074, 712648, 763049, 94884 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) heart lowest activity 675563 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) heart only a minor proportion of branched-chain 2-oxoacid dehydrogenase complex is active in mitochondria freshly prepared from rat heart 349077 1.20.4.2 methylarsonate reductase heart - 287856 1.21.99.3 thyroxine 5-deiodinase heart - 715102 1.21.99.4 thyroxine 5'-deiodinase heart - 714664 1.21.99.4 thyroxine 5'-deiodinase heart isozyme type I 644806 1.21.99.4 thyroxine 5'-deiodinase heart low level of activity 659941 1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] heart - -, 390714, 700872, 759138 1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase heart - 349254 1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase heart low activity 349239 1.3.1.24 biliverdin reductase heart - 711965 1.3.1.27 2-hexadecenal reductase heart - 390629 1.3.1.34 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing] heart - 652365 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH) heart TER mRNA 656193 1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase heart - 390820, 390826 1.3.1.70 DELTA14-sterol reductase heart foetal and adult 672378 1.3.1.70 DELTA14-sterol reductase heart in foetal heart the expression is much lower then in the adult heart, TM7SF2 672378 1.3.1.72 DELTA24-sterol reductase heart - 745890 1.3.1.8 acyl-CoA dehydrogenase (NADP+) heart - 685980 1.3.3.3 coproporphyrinogen oxidase heart - 390967 1.3.3.6 acyl-CoA oxidase heart - 391044, 391071 1.3.5.1 succinate dehydrogenase heart - 2877, 391081, 391117, 391120, 391123, 391126, 391130, 391136, 391146, 391165, 391179, 391180, 391191, 657158, 671041, 672379, 672944, 686054, 686649, 695601, 696701, 742297, 763269 1.3.5.1 succinate dehydrogenase heart decreased complex II activity in diabetic hearts compared to control 673796 1.3.5.1 succinate dehydrogenase heart expression of 2 distinct flavoprotein subunits 654444 1.3.5.2 dihydroorotate dehydrogenase (quinone) heart - 390925 1.3.8.1 short-chain acyl-CoA dehydrogenase heart - 391199, 391283 1.3.8.1 short-chain acyl-CoA dehydrogenase heart left ventricle -, 762716 1.3.8.6 glutaryl-CoA dehydrogenase (ETF) heart - 391407 1.3.8.7 medium-chain acyl-CoA dehydrogenase heart - 391283, 391361, 685980 1.3.8.8 long-chain acyl-CoA dehydrogenase heart - 391361, 684346 1.3.8.8 long-chain acyl-CoA dehydrogenase heart activity declines 34% during 30 min of ischemia 671584 1.3.8.8 long-chain acyl-CoA dehydrogenase heart very low enzyme content 713044 1.3.8.9 very-long-chain acyl-CoA dehydrogenase heart - 763263 1.3.99.23 all-trans-retinol 13,14-reductase heart low enzyme content 763769 1.4.1.2 glutamate dehydrogenase heart systemic 391558 1.4.1.3 glutamate dehydrogenase [NAD(P)+] heart - 391541, 699005 1.4.3.1 D-aspartate oxidase heart - 711721 1.4.3.13 protein-lysine 6-oxidase heart - 391741, 659558, 688955 1.4.3.13 protein-lysine 6-oxidase heart co-localization of LOX and LOXL 659751 1.4.3.13 protein-lysine 6-oxidase heart lysyl oxidase protein expression is very scarce in normal hearts, it is highly expressed in failing hearts 698212 1.4.3.13 protein-lysine 6-oxidase heart only in fetal heart, LOXL2, very low expression level of LOXL3 658189 1.4.3.21 primary-amine oxidase heart - 701561, 703130 1.4.3.3 D-amino-acid oxidase heart lowest activity in heart 724793 1.4.3.4 monoamine oxidase heart increase in monoamine oxidase activity in both middle aged and aged rats, compared to young rats 686559 1.4.3.4 monoamine oxidase heart predominance of monoamine oxidase A, mRNA for monoamine oxidase B is present but the protein itself is undetected with beta-phenylethylamine as substrate 656683 1.4.3.5 pyridoxal 5'-phosphate synthase heart - 391879 1.4.3.5 pyridoxal 5'-phosphate synthase heart 3.7% of the activity in liver 655483 1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] heart - 392038 1.5.1.11 D-octopine dehydrogenase heart - 13290 1.5.1.17 alanopine dehydrogenase heart - 13290 1.5.1.25 thiomorpholine-carboxylate dehydrogenase heart high enzyme expression level 741580 1.5.1.3 dihydrofolate reductase heart knock-down of dihydrofolate reductase or heart and neural crest derivatives expressed transcript HAND2 in fertilized eggs causes cardiac malformation 686107 1.5.1.30 flavin reductase (NADPH) heart whole hearts 392298 1.5.1.34 6,7-dihydropteridine reductase heart low activity 484958 1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+) heart - -, 725456, 742856 1.5.1.6 formyltetrahydrofolate dehydrogenase heart - 392350 1.5.1.6 formyltetrahydrofolate dehydrogenase heart less activity 392335 1.5.1.6 formyltetrahydrofolate dehydrogenase heart moderate FDH mRNA level 392350 1.5.1.6 formyltetrahydrofolate dehydrogenase heart most highly expressed in pancreas, heart and brain 712450 1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming) heart - 656601 1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming) heart after liver next highest enzyme concentration 392361 1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming) heart high enzyme concentration 392362 1.5.3.16 spermine oxidase heart - 742553 1.5.3.16 spermine oxidase heart splice variant mSMO 692157 1.5.3.7 L-pipecolate oxidase heart - 392477 1.5.5.1 electron-transferring-flavoprotein dehydrogenase heart - 392479 1.5.5.1 electron-transferring-flavoprotein dehydrogenase heart high level expression 677116 1.5.8.4 dimethylglycine dehydrogenase heart detectable levels of expression demonstrated at the RNA and protein level 392525 1.5.99.B2 proline dehydrogenase (acceptor) heart - 392559 1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific) heart - -, 392595, 392597, 392601, 392606, 392607, 392608, 392611, 392614, 392615, 392616, 392617, 392620, 392621, 392622, 392623, 392624, 392625, 392626, 392628, 392629, 392630, 392631, 392632, 392633, 392634, 392635, 392636, 392637, 392640, 392642, 392644, 392646, 392655, 659243, 724953, 725068, 735294, 742241 1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific) heart highest expression level 658473 1.6.2.4 NADPH-hemoprotein reductase heart - 288592, 671680 1.6.2.4 NADPH-hemoprotein reductase heart alpha-lipoic acid decreases enzyme activity in lung and heart 671348 1.6.3.1 NAD(P)H oxidase (H2O2-forming) heart - 685971, 686878, 696745, 711688 1.6.3.1 NAD(P)H oxidase (H2O2-forming) heart after myocardial infarction, NAD(P)H oxidase activity is markedly increased in remote left ventricular myocardium of wild-type mice but not in mice deficient in subunit p47phox. Increased myocardial xanthine oxidase activity is observed in wild-type, but not in p47phox-deficient mice after myocardial infarction. Left ventricular cavity dilatation and dysfunction 4 weeks after infarction are markedly attenuated in p47phox-deficient mice and cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis are substantially reduced as compared with wild-type. The survival rate is markedly higher in mice deficient in subunit p47phox 686113 1.6.3.1 NAD(P)H oxidase (H2O2-forming) heart expressed highly in hemocytes, followed by comparable expression in hepatopancreas and moderate expression in brain, eyestalk and intestine, but with relatively low expressions in gill, heart and muscle 744948 1.6.3.1 NAD(P)H oxidase (H2O2-forming) heart induction of superoxide production by doxorubicin is much higher in hearts of wild-type mice than in subunit gp91phox knock-out mice. Superoxide production is similarly induced by addition of NADPH cytochrome P450 reductase 686861 1.6.3.1 NAD(P)H oxidase (H2O2-forming) heart left ventricle 712062 1.6.3.1 NAD(P)H oxidase (H2O2-forming) heart rabbits with heart failure induced by myocardial infarction exhibit left ventricular dilatation and systolic dysfunction. Changes are associated with increases in NADPH oxidase activity, subunit p47phox protein expression, 8-hydroxydeoxyguanosine expression, 4-hydroxy-2-nonenal expression, myocyte apoptosis, and Bax protein and a decrease in Bcl-2 protein 686870 1.6.3.1 NAD(P)H oxidase (H2O2-forming) heart the amount of NOX4 is elevated in hearts of db/db diabetic mice compared to wild-type mice -, 725065 1.6.3.5 renalase heart - 741788, 743215 1.6.3.5 renalase heart besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine 728036 1.6.5.2 NAD(P)H dehydrogenase (quinone) heart - 394352, 394366 1.6.5.4 monodehydroascorbate reductase (NADH) heart - 392734 1.7.1.11 4-(dimethylamino)phenylazoxybenzene reductase heart - 394432 1.7.1.7 GMP reductase heart - 659550 1.7.2.1 nitrite reductase (NO-forming) heart - 698840 1.7.2.2 nitrite reductase (cytochrome; ammonia-forming) heart - 742913 1.8.1.10 CoA-glutathione reductase heart - 395105 1.8.1.4 dihydrolipoyl dehydrogenase heart - 393971, 393982, 393993, 658231, 658431, 658600, 658742, 659167, 674430, 692060, 694854, 712097 1.8.1.4 dihydrolipoyl dehydrogenase heart significant increase in DLDH dehydrogenase activity in rats only for the period between 30 and 60 days of age 693975 1.8.1.7 glutathione-disulfide reductase heart - 673460, 742814 1.8.1.7 glutathione-disulfide reductase heart expression only before puberty 659484 1.8.1.9 thioredoxin-disulfide reductase heart - 712943 1.8.1.9 thioredoxin-disulfide reductase heart transcription of TXNRD1 involves alternative splicing, leading to a number of transcripts also encoding isoforms of TrxR1 that differ from each other at their N-terminal domains. The TXNRD1_v3 isoform contains an atypical N-terminal glutaredoxin domain. Expression of the transcript of this isoform is found predominantly in testis but is also detected in ovary, spleen, heart, liver, kidney, and pancreas 687762 1.8.3.1 sulfite oxidase heart - 393016, 657738, 701313 1.8.3.1 sulfite oxidase heart substantial expression 657738 1.8.3.2 thiol oxidase heart - 667821 1.8.3.2 thiol oxidase heart small amounts 393063 1.8.3.5 prenylcysteine oxidase heart - 437708 1.8.4.11 peptide-methionine (S)-S-oxide reductase heart maximal expression level of MsrA in kidney and liver, followed by heart, lung, brain, skeletal muscle, retina, testis, bone marrow, and blood 763918 1.8.4.11 peptide-methionine (S)-S-oxide reductase heart ventricle, high MsrA expression level 668581 1.8.4.12 peptide-methionine (R)-S-oxide reductase heart - 686598, 712462, 713362 1.8.4.12 peptide-methionine (R)-S-oxide reductase heart highest expression 711940 1.8.4.12 peptide-methionine (R)-S-oxide reductase heart highly expressed 686598 1.8.4.12 peptide-methionine (R)-S-oxide reductase heart isozymes MsrB3 and MsrB2 669008 1.8.4.12 peptide-methionine (R)-S-oxide reductase heart most abundant in ventricles, interventricular septum, and apex 658704 1.8.4.2 protein-disulfide reductase (glutathione) heart - 394810, 394811, 394817, 394828 1.8.4.3 glutathione-CoA-glutathione transhydrogenase heart low activity 395011 1.8.4.7 enzyme-thiol transhydrogenase (glutathione-disulfide) heart - 394699 1.8.5.1 glutathione dehydrogenase (ascorbate) heart - 394033 1.8.5.4 bacterial sulfide:quinone reductase heart - 742246 1.8.5.8 eukaryotic sulfide quinone oxidoreductase heart - 764408 1.8.98.2 sulfiredoxin heart - 742457, 742566 2.1.1.1 nicotinamide N-methyltransferase heart - -, 706094 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase heart - 485033 2.1.1.114 polyprenyldihydroxybenzoate methyltransferase heart - 485141 2.1.1.13 methionine synthase heart - 441177 2.1.1.137 arsenite methyltransferase heart - 659168, 721074 2.1.1.166 23S rRNA (uridine2552-2'-O)-methyltransferase heart transcripts are abundant 703879 2.1.1.2 guanidinoacetate N-methyltransferase heart - 687899, 690096 2.1.1.2 guanidinoacetate N-methyltransferase heart low enzyme level 485207 2.1.1.22 carnosine N-methyltransferase heart low activity 485238 2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase heart - 485141 2.1.1.233 [phosphatase 2A protein]-leucine-carboxy methyltransferase heart - -, 732777, 737114 2.1.1.233 [phosphatase 2A protein]-leucine-carboxy methyltransferase heart left ventricular tissue 722804 2.1.1.244 protein N-terminal methyltransferase heart high enzyme expression levels 717248 2.1.1.28 phenylethanolamine N-methyltransferase heart - -, 639430, 697358 2.1.1.28 phenylethanolamine N-methyltransferase heart transient developmental burst in enzyme expression in the embryonic rat heart from E9.5 to E13.0 639452 2.1.1.28 phenylethanolamine N-methyltransferase heart weak activity 639430 2.1.1.299 protein N-terminal monomethyltransferase heart - 756463 2.1.1.321 type III protein arginine methyltransferase heart - 757338 2.1.1.325 juvenile hormone-III synthase heart - 738375, 738943, 739243 2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase heart high expression within developing heart 734692 2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase heart PRDM8 of 30 kDa is expressed most prominently in cardiomyocytes from the heart 702068 2.1.1.359 [histone H3]-lysine36 N-trimethyltransferase heart - 754881 2.1.1.4 acetylserotonin O-methyltransferase heart - 703589 2.1.1.45 thymidylate synthase heart parasitic helminth, obtained from the pulmonary hearts and vessels of infected Wistar albino rats 485404 2.1.1.49 amine N-methyltransferase heart - 441356 2.1.1.6 catechol O-methyltransferase heart - 441507, 441508, 441514, 658885, 720288 2.1.1.6 catechol O-methyltransferase heart L-COMT is the predominant enzyme form 702121 2.1.1.61 tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase heart - 658202 2.1.1.61 tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase heart abundantly expressed in tissues with high metabolic rates 671744 2.1.1.64 3-demethylubiquinol 3-O-methyltransferase heart - 485141 2.1.1.67 thiopurine S-methyltransferase heart - 686275 2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase heart sarcolemma, sarcolemmal vesicles -, 485559 2.1.1.72 site-specific DNA-methyltransferase (adenine-specific) heart - 719373 2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase heart - 485595, 485600, 485605, 485617 2.1.1.8 histamine N-methyltransferase heart - 441556 2.1.2.1 glycine hydroxymethyltransferase heart elevated mRNA expression detected by RT-PCT 686353 2.1.2.2 phosphoribosylglycinamide formyltransferase 1 heart - 673825 2.1.4.1 glycine amidinotransferase heart - 485965, 485974, 485975 2.2.1.2 transaldolase heart - 736429 2.2.1.5 2-hydroxy-3-oxoadipate synthase heart - 395924, 395928, 395929, 657709 2.2.1.5 2-hydroxy-3-oxoadipate synthase heart distribution in rat tissues 395928 2.3.1.105 alkylglycerophosphate 2-O-acetyltransferase heart - 486103 2.3.1.12 dihydrolipoyllysine-residue acetyltransferase heart - 348910, 348927, 348938, 348941, 348955, 486174, 486175, 486176, 486194, 486202, 486235, 642164, 94893 2.3.1.121 1-alkenylglycerophosphoethanolamine O-acyltransferase heart - 486241 2.3.1.123 dolichol O-acyltransferase heart slight activity 486245 2.3.1.135 phosphatidylcholine-retinol O-acyltransferase heart - -, 674449 2.3.1.137 carnitine O-octanoyltransferase heart - 486293, 486294, 486307 2.3.1.137 carnitine O-octanoyltransferase heart high expression of CRAT -, 686028 2.3.1.142 glycoprotein O-fatty-acyltransferase heart - -, 486323 2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent) heart - 16268 2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent) heart - 16278 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase heart - 486345, 676839, 685377, 688948, 702433, 756106, 757868 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase heart high expression 701623 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase heart high expression level 757165 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase heart low expression 701623 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase heart moderate expression 701623 2.3.1.16 acetyl-CoA C-acyltransferase heart - 33713, 486403, 486404, 486408, 486417, 686251, 735368 2.3.1.16 acetyl-CoA C-acyltransferase heart di-(2-ethylhexyl)phthalate-inducible acetyl-CoA hydrolase activity 664215 2.3.1.16 acetyl-CoA C-acyltransferase heart muscle 486412 2.3.1.20 diacylglycerol O-acyltransferase heart - 486505 2.3.1.20 diacylglycerol O-acyltransferase heart greater abundance of isozyme DGAT2 mRNA in the heart compared to isozyme DGAT1 758435 2.3.1.21 carnitine O-palmitoyltransferase heart - 486522, 486526, 486527, 486530, 486537, 486542, 486543, 486556, 486558, 486559, 486567, 486577, 486584, 487413, 657652, 657733, 657826, 675740, 686125, 702111, 702112, 705296, 705679, 720974 2.3.1.21 carnitine O-palmitoyltransferase heart 2 isoforms of CPT I 486571 2.3.1.21 carnitine O-palmitoyltransferase heart CPT II, M-CPT I and low content of L-CPT I 486577 2.3.1.21 carnitine O-palmitoyltransferase heart CPT1-B 659899 2.3.1.21 carnitine O-palmitoyltransferase heart high level of mRNA 657826 2.3.1.21 carnitine O-palmitoyltransferase heart highest activity in liver and heart 736191 2.3.1.21 carnitine O-palmitoyltransferase heart isozyme M-CPT I 674520 2.3.1.21 carnitine O-palmitoyltransferase heart L-CPT I 486585 2.3.1.21 carnitine O-palmitoyltransferase heart M-CPT I 486575, 486585 2.3.1.21 carnitine O-palmitoyltransferase heart predominant expression 735980 2.3.1.22 2-acylglycerol O-acyltransferase heart - 705006 2.3.1.225 protein S-acyltransferase heart DHHC9 720174 2.3.1.225 protein S-acyltransferase heart isoform DHHC5 is among the most abundantly expressed DHHCs in the heart and localizes to caveolin-enriched cell surface microdomains. DHHC5 coimmunoprecipitates with cardiac protein phospholemman in ventricular myocytes and transiently transfected cells 737163 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase heart - 486618, 486622, 486626, 486629, 486631, 657761 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase heart low content 755989 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase heart myocardium 486625 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase heart northern blot analysis 688774 2.3.1.25 plasmalogen synthase heart - 486649 2.3.1.255 N-terminal amino-acid Nalpha-acetyltransferase NatA heart - 659263 2.3.1.26 sterol O-acyltransferase heart - 486703, 686560 2.3.1.26 sterol O-acyltransferase heart 6fold induction of activity after 60 days of cholesterol feeding 486683 2.3.1.26 sterol O-acyltransferase heart ACAT1 enzyme, high mRNA signal 486706 2.3.1.26 sterol O-acyltransferase heart low expression 486698 2.3.1.286 protein acetyllysine N-acetyltransferase heart - 739745 2.3.1.29 glycine C-acetyltransferase heart - 486747 2.3.1.37 5-aminolevulinate synthase heart - 756863 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I heart most abundant 659451 2.3.1.42 glycerone-phosphate O-acyltransferase heart - 486950, 486975 2.3.1.43 phosphatidylcholine-sterol O-acyltransferase heart - 755917 2.3.1.5 arylamine N-acetyltransferase heart - 685494 2.3.1.5 arylamine N-acetyltransferase heart NAT2 expression detected in adult mice 685494 2.3.1.5 arylamine N-acetyltransferase heart Nat2 expression is both temporally and spatially regulated during development. In neonatal mice, cardiac Nat2 expression is most extensive in the central fibrous body and is evident in the atrioventricular valves and the valves of the great vessels. Nat2 expression is not detected in ventricular myocardial cells. Nat2 is strongly expressed in scattered cells in the region of the sinus node, the epicardium of the right atrial appendage, and in the pulmonary artery. Expression of active NAT2 protein is maximal when the developing heart attains the adult circulation pattern and moves from metabolizing glucose to fatty acids 659624 2.3.1.50 serine C-palmitoyltransferase heart isozyme SPT2 676928 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase heart - 486345, 671597, 705206, 756108 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase heart analysis of enzyme mRNA expression, transcript of approximately 2 kb length dominant 487202 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase heart low expression level -, 705005 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase heart mAGPAT1, mAGPAT2, mAGPAT3, mAGPAT4 barely detectable, mAGPAT5 expressed at high levels, mRNA expression of cardiac mAGPAT3 is regulated by activation of peroxisome-proliferator-activated receptors 657854 2.3.1.57 diamine N-acetyltransferase heart - 737100 2.3.1.61 dihydrolipoyllysine-residue succinyltransferase heart - 348914, 487336, 487343, 487344, 487345, 487348, 659354, 735580, 756495 2.3.1.62 2-acylglycerophosphocholine O-acyltransferase heart - 487355 2.3.1.7 carnitine O-acetyltransferase heart - -, 486295, 487397, 487398, 487399, 487400, 487403, 487404, 487407, 487416, 487417, 487418, 487421, 487422, 487423, 487424, 487428, 487429, 487430, 756008 2.3.1.7 carnitine O-acetyltransferase heart Crat is most highly expressed in heart, brown adipose tissue and white adipose tissue 686028 2.3.1.9 acetyl-CoA C-acetyltransferase heart - 486408, 487667, 487670, 487674 2.3.1.97 glycylpeptide N-tetradecanoyltransferase heart - 487775 2.3.1.97 glycylpeptide N-tetradecanoyltransferase heart low activity 487754, 487756 2.3.1.B41 protein-long-chain fatty-acyl-lysine deacylase (NAD+) heart - 738170, 756672, 758395 2.3.1.B43 protein-lysine desuccinylase (NAD+) heart - 739069, 755970, 756522, 757184 2.3.2.13 protein-glutamine gamma-glutamyltransferase heart - 658504 2.3.2.13 protein-glutamine gamma-glutamyltransferase heart high activity 735731 2.3.2.2 gamma-glutamyltransferase heart - 736220 2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme heart - 759177 2.3.2.27 RING-type E3 ubiquitin transferase heart abundantly expressed 652301 2.3.2.5 glutaminyl-peptide cyclotransferase heart - 704085 2.3.2.8 arginyltransferase heart - -, 703373, 706444, 736259, 758964 2.3.2.8 arginyltransferase heart enhanced ATE1 expression in hypertrophied heart samples, quantitative real-time-PCR expression analysis 760135 2.3.2.B12 ubiquitin transferase U-box E4 heart - 726851 2.3.3.1 citrate (Si)-synthase heart - 488032, 488058, 674428, 689719 2.3.3.1 citrate (Si)-synthase heart ventricular tissue with greater activity than right atrium 488065 2.3.3.10 hydroxymethylglutaryl-CoA synthase heart - 720426 2.3.3.16 citrate synthase (unknown stereospecificity) heart - 488082, 701519, 756858 2.3.3.8 ATP citrate synthase heart - 33352 2.3.3.8 ATP citrate synthase heart low expression 718760 2.4.1.1 glycogen phosphorylase heart - 488281, 488283, 720110 2.4.1.1 glycogen phosphorylase heart at the protein level, but not at the mRNA level, the content of brain isoform of glycogen phosphorylase is similar in heart and brain. MM is more abundant in the heart than in the brain. Muscle isoform of glycogen phosphorylase is more abundant in the heart than in the brain. The brain isoform is colocalized with the muscle isoform in cardiomyocytes. The muscle isoform is also detected in interstitial cells identified as fibroblasts 689181 2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase heart isozyme B, low content of isozyme A 488381 2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase heart - 638288 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase heart - 673882, 723102 2.4.1.11 glycogen(starch) synthase heart - 488411, 488413, 488429, 488433, 756508 2.4.1.11 glycogen(starch) synthase heart high expression level of GYS1 -, 720446 2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase heart - 489314 2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase heart high content 638326 2.4.1.133 xylosylprotein 4-beta-galactosyltransferase heart - 637200 2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase heart - 659141 2.4.1.143 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase heart - 658859 2.4.1.145 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase heart - 703913 2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase heart very weak expression of beta3GnT7 -, 638581 2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase heart IGnT is moderately expressed in adult heart 638567 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase heart - 703701 2.4.1.174 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase heart - 638346, 723586 2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase heart - 638346, 638349, 659262, 690806, 693037, 723586 2.4.1.186 glycogenin glucosyltransferase heart - 736558, 759024, 759550 2.4.1.212 hyaluronan synthase heart - 736219 2.4.1.221 peptide-O-fucosyltransferase heart - 441441 2.4.1.224 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase heart - 737087 2.4.1.225 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase heart - 737087 2.4.1.225 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase heart high level of EXT2 in EXT2-overexpressing mice 706496 2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase heart - 722567 2.4.1.255 protein O-GlcNAc transferase heart - 489611, 489616, 701899, 705266, 721502, 722774 2.4.1.255 protein O-GlcNAc transferase heart 110 kDa subunit 674603 2.4.1.274 glucosylceramide beta-1,4-galactosyltransferase heart - 714294, 715435 2.4.1.275 neolactotriaosylceramide beta-1,4-galactosyltransferase heart - 715438 2.4.1.313 protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase heart - 725358 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase heart - 687078 2.4.1.40 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase heart A-type enzyme expression 658843 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase heart - 489182, 719570 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase heart low level of isozyme T4 489199 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase heart Northern analysis of eight human tissues differ clearly from that of the bovine GalNAc-transferase 659127 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase heart Northern blot analysis of human tissues 659136 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase heart ppGaNTase-T9, less amount 489182 2.4.1.50 procollagen galactosyltransferase heart - 705703 2.4.1.62 ganglioside galactosyltransferase heart - 489314 2.4.1.66 procollagen glucosyltransferase heart - 675031, 724792 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase heart - 489336 2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase heart - 489344 2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase heart - 489386 2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase heart strong gene expression 680030 2.4.1.80 ceramide glucosyltransferase heart - -, 736820 2.4.1.80 ceramide glucosyltransferase heart mRNA 489413 2.4.1.87 N-acetyllactosaminide 3-alpha-galactosyltransferase heart - 658837 2.4.2.1 purine-nucleoside phosphorylase heart - -, 489654, 760109 2.4.2.1 purine-nucleoside phosphorylase heart similar activity for ischemic tissue and normal tissue of hte same heart 706743 2.4.2.12 nicotinamide phosphoribosyltransferase heart - 489741, 703243, 722560, 736003, 759372 2.4.2.16 urate-ribonucleoside phosphorylase heart - 639636 2.4.2.26 protein xylosyltransferase heart - -, 637616, 637619 2.4.2.26 protein xylosyltransferase heart isoform XT-II, low content 637619 2.4.2.26 protein xylosyltransferase heart sternal cartilage 637615, 637616 2.4.2.28 S-methyl-5'-thioadenosine phosphorylase heart left ventricular specimen -, 637552 2.4.2.28 S-methyl-5'-thioadenosine phosphorylase heart low activity 637528 2.4.2.3 uridine phosphorylase heart embryo 673810 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase heart - 638109, 638113, 657869, 672357, 759729 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase heart Art7.1 and Art7.2 705674 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase heart low activity 638110 2.4.2.4 thymidine phosphorylase heart - -, 703961 2.4.2.9 uracil phosphoribosyltransferase heart - 675195 2.4.2.9 uracil phosphoribosyltransferase heart low level of expression 675195 2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase heart - 659082 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase heart - 739511, 745044 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase heart high activity 744207 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase heart high expression 744836 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase heart highly expressed 744836 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase heart type 1 and type 2 mRNA isoform (differ in 5'-untranslated region) 744211 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase heart weak expression 745044 2.4.3.6 N-acetyllactosaminide alpha-2,3-sialyltransferase heart - 745044 2.4.3.7 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase heart constitutive expression of STGalNac IV gene 638774 2.4.3.7 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase heart expression of ST6GalNAc VI 671891 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase heart - 638784 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase heart normal quantity of ST8Sia I_long 681899 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase heart - 739511 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase heart high transcript level of SAT-Ia and SAT-Ib transcript 705616 2.5.1.141 heme o synthase heart the gene is expressed in multiple tissues with highest expression observed in the heart, skeletal muscle, and testis 727597 2.5.1.18 glutathione transferase heart - 737658, 759081 2.5.1.2 thiamine pyridinylase heart - 636845 2.5.1.22 spermine synthase heart - 657842 2.5.1.29 geranylgeranyl diphosphate synthase heart - 759005 2.5.1.29 geranylgeranyl diphosphate synthase heart expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form 659091 2.5.1.39 4-hydroxybenzoate polyprenyltransferase heart - 636998 2.5.1.39 4-hydroxybenzoate polyprenyltransferase heart high enzyme expression 657846 2.5.1.57 N-acylneuraminate-9-phosphate synthase heart - 637814 2.5.1.6 methionine adenosyltransferase heart mainly MAT2beta variant 2 686926 2.6.1.1 aspartate transaminase heart - 639816, 639817, 639821, 639824, 639825, 639831, 639834, 639838, 639850, 639865, 639872, 639875, 659930, 672695, 704082, 721785 2.6.1.13 ornithine aminotransferase heart - 637126, 703993 2.6.1.2 alanine transaminase heart - 676963 2.6.1.26 thyroid-hormone transaminase heart low activity 639937 2.6.1.39 2-aminoadipate transaminase heart - 639985 2.6.1.4 glycine transaminase heart limited activity 639986 2.6.1.42 branched-chain-amino-acid transaminase heart - -, 639994, 639997, 640009, 640010, 640014, 640017, 640019, 640023, 640031, 640037, 640039 2.6.1.42 branched-chain-amino-acid transaminase heart heart muscle 639993, 639995 2.6.1.47 alanine-oxomalonate transaminase heart - 636686 2.6.1.5 tyrosine transaminase heart - 640103, 759114 2.6.1.64 glutamine-phenylpyruvate transaminase heart - -, 640173, 640174 2.6.1.7 kynurenine-oxoglutarate transaminase heart - 636633, 703133 2.6.1.7 kynurenine-oxoglutarate transaminase heart KAT 1, low activity 636630 2.6.1.7 kynurenine-oxoglutarate transaminase heart low activity 636634 2.7.1.1 hexokinase heart - 640220, 640223, 640227, 671249, 722275 2.7.1.1 hexokinase heart 2 isoenzymes 640246 2.7.1.1 hexokinase heart hexokinase I 640229 2.7.1.1 hexokinase heart low activity 759359 2.7.1.105 6-phosphofructo-2-kinase heart - 640298, 640299, 640302, 640303, 640306, 640324, 640330, 640343, 673017, 760543, 94935, 94948 2.7.1.105 6-phosphofructo-2-kinase heart 2 isozymes: result of alternative splitting of the same primary transcript 640302 2.7.1.105 6-phosphofructo-2-kinase heart heart isozyme PFKFB2 -, 730008 2.7.1.105 6-phosphofructo-2-kinase heart heart PFK-2 isozyme 739456 2.7.1.105 6-phosphofructo-2-kinase heart long isozyme variants H1-PFK2, H2-PFK2, and H4-PFK2, and short isozyme variant H3-PFK2 737973 2.7.1.105 6-phosphofructo-2-kinase heart transgenic mice, expressed in 690361 2.7.1.105 6-phosphofructo-2-kinase heart two isozymic forms 640306, 94949 2.7.1.107 diacylglycerol kinase (ATP) heart - 690336, 691652, 701628, 761126 2.7.1.107 diacylglycerol kinase (ATP) heart DGKdelta is the most abundant isoform in murine heart tissue 737685 2.7.1.107 diacylglycerol kinase (ATP) heart low activity 640364 2.7.1.107 diacylglycerol kinase (ATP) heart low expression 701582 2.7.1.11 6-phosphofructokinase heart - 640421, 640487 2.7.1.11 6-phosphofructokinase heart low expression 684338 2.7.1.113 deoxyguanosine kinase heart - 640562 2.7.1.127 inositol-trisphosphate 3-kinase heart InsP3 3-kinase B mRNA 640751 2.7.1.127 inositol-trisphosphate 3-kinase heart isoform C 640761 2.7.1.127 inositol-trisphosphate 3-kinase heart isozymes IP33K-B, and IP33K-C 661446 2.7.1.134 inositol-tetrakisphosphate 1-kinase heart - 640814 2.7.1.134 inositol-tetrakisphosphate 1-kinase heart 3.6 kilobases transcript detected by Northern blot 640816 2.7.1.137 phosphatidylinositol 3-kinase heart - -, 640920, 661498, 708146, 760521 2.7.1.137 phosphatidylinositol 3-kinase heart activation of the prosurvival phosphatidylinositol 3-kinase-Akt pathway is involved in the protective action of poly(ADP-ribose) polymerase 1 inhibition in a model of donor heart procurement and hypothermic storage 690164 2.7.1.137 phosphatidylinositol 3-kinase heart p87PIKAP is a regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with phosphodiesterase 3B 674783 2.7.1.138 ceramide kinase heart high activity 662592 2.7.1.138 ceramide kinase heart highest mRNA expression level 640968 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase heart high mRNA expression 684375 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase heart PIP4Kgamma in heart run predominantly as a 40 kDa band, suggesting that processing of this isoform occurs. 684375 2.7.1.151 inositol-polyphosphate multikinase heart - 393223 2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase heart - 640916 2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase heart PI3Kgamma, small amounts 710598 2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase heart - -, 640880 2.7.1.158 inositol-pentakisphosphate 2-kinase heart - 662117 2.7.1.160 2'-phosphotransferase heart - 690027 2.7.1.160 2'-phosphotransferase heart high level of TRPT1 transcript 668216 2.7.1.171 protein-fructosamine 3-kinase heart - 708296, 708981 2.7.1.172 protein-ribulosamine 3-kinase heart - 708981 2.7.1.172 protein-ribulosamine 3-kinase heart expressed at low levels 708296 2.7.1.173 nicotinate riboside kinase heart - 738213 2.7.1.183 glycoprotein-mannosyl O6-kinase heart - 762066 2.7.1.20 adenosine kinase heart - -, 641091, 641099, 721929 2.7.1.20 adenosine kinase heart low expression level 661642 2.7.1.20 adenosine kinase heart myocard -, 641073, 641075, 641080 2.7.1.22 ribosylnicotinamide kinase heart predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue -, 758846 2.7.1.23 NAD+ kinase heart - 641178, 641202, 691390 2.7.1.23 NAD+ kinase heart highest expression 723257 2.7.1.3 ketohexokinase heart - 4933, 760194 2.7.1.3 ketohexokinase heart relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues 678985 2.7.1.30 glycerol kinase heart - 721260 2.7.1.30 glycerol kinase heart increased level during embryonic development 660906 2.7.1.31 glycerate 3-kinase heart - 673281 2.7.1.32 choline kinase heart - 641346 2.7.1.32 choline kinase heart high expression of the beta subtype 663274 2.7.1.33 pantothenate kinase heart - -, 641392 2.7.1.33 pantothenate kinase heart mainly isoform mPanK1alpha 641397 2.7.1.33 pantothenate kinase heart ventricular muscle -, 641391 2.7.1.36 mevalonate kinase heart - 690694 2.7.1.40 pyruvate kinase heart - 641518, 641528, 641572, 675943, 738760 2.7.1.40 pyruvate kinase heart strong expression in skeletal muscle, heart, and brain 691908 2.7.1.40 pyruvate kinase heart type M-isozyme 641547, 641555 2.7.1.48 uridine/cytidine kinase heart 85% of liver activity 641653 2.7.1.48 uridine/cytidine kinase heart uridine kinase 1 mRNA 641655 2.7.1.52 fucokinase heart - 641674, 661521, 661649, 703298 2.7.1.59 N-acetylglucosamine kinase heart - 641701 2.7.1.67 1-phosphatidylinositol 4-kinase heart - 641769 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase heart high expression of PIP5KIbeta and PIP5KIalpha 641842 2.7.1.74 deoxycytidine kinase heart - 706844 2.7.1.74 deoxycytidine kinase heart low enzyme activity 706844 2.7.1.76 2'-deoxyadenosine kinase heart low activity 641099 2.7.1.82 ethanolamine kinase heart - 674650 2.7.1.91 sphingosine kinase heart - 661509, 672942, 674380, 674746, 687479, 703086, 703087 2.7.1.91 sphingosine kinase heart expression of long-rSK1 mRNA, no expression of rSK1 mRNA 684883 2.7.1.91 sphingosine kinase heart major isozyme is SPHK1 660860 2.7.1.94 acylglycerol kinase heart - 662505 2.7.10.1 receptor protein-tyrosine kinase heart - 490038, 490394, 490400, 490487, 490528, 490599, 490615, 660678, 662841, 672957 2.7.10.1 receptor protein-tyrosine kinase heart vascular endothelial growth factor receptor 660727 2.7.10.2 non-specific protein-tyrosine kinase heart - 490044, 660678, 661458 2.7.10.2 non-specific protein-tyrosine kinase heart expression at low level 492004 2.7.10.2 non-specific protein-tyrosine kinase heart faintly 490349 2.7.10.2 non-specific protein-tyrosine kinase heart weak activity 490673 2.7.11.1 non-specific serine/threonine protein kinase heart - 491060, 491332, 491403, 491630, 693696 2.7.11.1 non-specific serine/threonine protein kinase heart expression detected by RT-PCR 691552 2.7.11.1 non-specific serine/threonine protein kinase heart high expression level of splicing variant alpha of the testis specific serine/threonine kinase 674390 2.7.11.1 non-specific serine/threonine protein kinase heart high expression level of splicing variant beta of the testis specific serine/threonine kinase 674390 2.7.11.1 non-specific serine/threonine protein kinase heart high expression level of splicing variant delta of the testis specific serine/threonine kinase 674390 2.7.11.1 non-specific serine/threonine protein kinase heart high expression level of splicing variant gamma of the testis specific serine/threonine kinase 674390 2.7.11.1 non-specific serine/threonine protein kinase heart low enzyme level 742344 2.7.11.1 non-specific serine/threonine protein kinase heart very low expression level of WNK1 661007 2.7.11.1 non-specific serine/threonine protein kinase heart very low ULK3 expression level 722198 2.7.11.11 cAMP-dependent protein kinase heart - -, 490954, 661501, 662347, 671678, 672227, 673668, 675671, 693043, 721663, 721744, 738786, 760651, 762271 2.7.11.12 cGMP-dependent protein kinase heart - 661575, 673462, 739538 2.7.11.12 cGMP-dependent protein kinase heart expressed at a much higher level in newborn than in adult 490948 2.7.11.12 cGMP-dependent protein kinase heart low expression of isozymes PKG-1alpha and PKG-1beta 660671 2.7.11.13 protein kinase C heart - 491129, 491130, 662837, 671952 2.7.11.15 beta-adrenergic-receptor kinase heart - 491019, 644999, 645016, 661455, 661495, 661499, 661502, 661825, 662730, 676101, 676131, 677232, 684461, 689094, 702536, 703084, 738625, 738695 2.7.11.15 beta-adrenergic-receptor kinase heart about 40% of beta-ARK mRNA concentration in brain 490985 2.7.11.15 beta-adrenergic-receptor kinase heart adult heart 645027 2.7.11.15 beta-adrenergic-receptor kinase heart beta-ARK 1 is the predominant myocardial GRK 645016 2.7.11.15 beta-adrenergic-receptor kinase heart distribution of GRK2 in mouse myocardial tissue, overview 687689 2.7.11.15 beta-adrenergic-receptor kinase heart distribution of GRK3 in mouse myocardial tissue, overview 687689 2.7.11.15 beta-adrenergic-receptor kinase heart during myocardial ischemia the membrane activity of beta-ARK is increased 645024 2.7.11.15 beta-adrenergic-receptor kinase heart enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58 491019 2.7.11.15 beta-adrenergic-receptor kinase heart GRK3 expression is not increased in heart failure 677258 2.7.11.15 beta-adrenergic-receptor kinase heart moderate expression of beta-ARK 1 490989 2.7.11.15 beta-adrenergic-receptor kinase heart moderate expression of beta-ARK 2 491003 2.7.11.15 beta-adrenergic-receptor kinase heart significantly increased expression of beta-ARK 1 in the hearts of BIO53.58 hamsters compared to control hamsters F1b 491019 2.7.11.16 G-protein-coupled receptor kinase heart - 491156, 491168, 661455, 661495, 671352 2.7.11.16 G-protein-coupled receptor kinase heart GRK5 expression is increased in heart failure 677258 2.7.11.16 G-protein-coupled receptor kinase heart high activity 491154 2.7.11.17 Ca2+/calmodulin-dependent protein kinase heart - 490757, 491258, 672384, 672940, 672941, 675065, 690363, 691539, 691837, 693128, 740268 2.7.11.17 Ca2+/calmodulin-dependent protein kinase heart CaMKII, no expression of CaMKIV 664537 2.7.11.17 Ca2+/calmodulin-dependent protein kinase heart delta-CaMKII isoform expression pattern in human hearts and changes in this expression pattern in heart failure 491281 2.7.11.17 Ca2+/calmodulin-dependent protein kinase heart Left ventricular myocardial tissue 740328 2.7.11.18 myosin-light-chain kinase heart - -, 661436, 741247, 761774 2.7.11.18 myosin-light-chain kinase heart cardiac-specific myosin light chain kinase 686119 2.7.11.18 myosin-light-chain kinase heart left ventricle tissue, MLCK occurs in a cross-striated pattern overlapping with the distribution of alpha-actin 672981 2.7.11.18 myosin-light-chain kinase heart specific cardiac/ventricular isozyme cardiac-MLCK 675068 2.7.11.18 myosin-light-chain kinase heart specific cardiac/ventricular isozyme cardiac-MLCK encoded by gene MLCK3, expression analysis in healthy hearts and hearts from patients with heart failure 675068 2.7.11.18 myosin-light-chain kinase heart ventricle 687922 2.7.11.19 phosphorylase kinase heart - 491224, 676038 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase heart - -, 348935, 642133, 642136, 642142, 642143, 642152, 642159, 642164, 642165, 660923, 661046, 673007, 673162, 674730, 705630, 722780, 723006, 759502, 94884, 94893 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase heart appearance of isozyme PDK1 is limited to the heart, isozyme PDK2 642159 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase heart developing and adult heart, the latter contains 3 isozymes: PDHK1, PDHK2 and PDHK4, clear differences in protein expression patterns of the isoforms dependent on developmental stage, overview 642156 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase heart highest expression 759502 2.7.11.20 elongation factor 2 kinase heart - 760364, 760466 2.7.11.21 polo kinase heart - 677916, 706517 2.7.11.22 cyclin-dependent kinase heart - 491554 2.7.11.22 cyclin-dependent kinase heart low expression 679093 2.7.11.24 mitogen-activated protein kinase heart - -, 491732, 491769, 491787, 491790, 666322, 681966, 701443, 761111 2.7.11.25 mitogen-activated protein kinase kinase kinase heart - 695197 2.7.11.25 mitogen-activated protein kinase kinase kinase heart cardiac myocytes 691985 2.7.11.25 mitogen-activated protein kinase kinase kinase heart detection of MEKK4 transcripts to early myocardium, endocardium and to cardiac cushion cells that have executed epithelial to mesenchymal transformation 679428 2.7.11.25 mitogen-activated protein kinase kinase kinase heart highly expressed in myocardium of embryonic heart 691985 2.7.11.25 mitogen-activated protein kinase kinase kinase heart MLK3 and MLK7 691985 2.7.11.26 tau-protein kinase heart - 640834 2.7.11.27 [acetyl-CoA carboxylase] kinase heart - 640774, 644969, 661636 2.7.11.30 receptor protein serine/threonine kinase heart ALK2 and ALK5, atrioventricular cushion of developing heart 664715 2.7.11.30 receptor protein serine/threonine kinase heart low ALK7 expression level 664282 2.7.11.30 receptor protein serine/threonine kinase heart weak expression 761110 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase heart - -, 491403, 644969, 644989, 692267, 692365, 693405, 703277, 703348, 704431, 739785, 741016, 760910, 762101 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase heart healthy and ischemic 693328 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase heart highest expression of subunit AMPKalpha2 760910 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase heart highest expression of subunit AMPKgamma2a 760910 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase heart highest expression of subunit AMPKgamma3 760910 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase heart ischemic heart 703348 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase heart muscle 692814 2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase heart - -, 349056, 640578, 640583, 640585, 640587, 640590, 640591, 640594, 640598, 640599, 702742, 738618 2.7.12.1 dual-specificity kinase heart - 663924 2.7.12.2 mitogen-activated protein kinase kinase heart - 491786, 491833, 491931, 682214 2.7.12.2 mitogen-activated protein kinase kinase heart 93000 Da form 678560 2.7.12.2 mitogen-activated protein kinase kinase heart expression at low levels in adult brain, expression at high levels in neonatal brain 491922 2.7.12.2 mitogen-activated protein kinase kinase heart weak expression 677913 2.7.2.3 phosphoglycerate kinase heart - 761325 2.7.2.3 phosphoglycerate kinase heart of adult and newborn rats 642279 2.7.3.2 creatine kinase heart - 642371, 642372, 642373, 642375, 642376, 642377, 642382, 642383, 642384, 642385, 642388, 642391, 642393, 642395, 642397, 642400, 642401, 642403, 642404, 642405, 642414, 642417, 642420, 642422, 642436, 642438, 642440, 661220, 661528, 662511, 662524, 675240, 704082, 761710, 762027 2.7.3.2 creatine kinase heart enzyme variants I–IV 642380 2.7.3.2 creatine kinase heart human heart cDNA library is used 722684 2.7.3.3 arginine kinase heart - 703776 2.7.4.10 nucleoside-triphosphate-adenylate kinase heart - 642534, 642535, 642536, 642537 2.7.4.15 thiamine-diphosphate kinase heart - 645166 2.7.4.21 inositol-hexakisphosphate 5-kinase heart faintly expressed 393220 2.7.4.21 inositol-hexakisphosphate 5-kinase heart weak activity 642551 2.7.4.3 adenylate kinase heart - 642558, 642566, 642568, 642569, 642572, 642618, 672502, 693007 2.7.4.3 adenylate kinase heart isoform AK2 642621 2.7.4.3 adenylate kinase heart muscle isozyme 642601 2.7.4.6 nucleoside-diphosphate kinase heart - 642628, 642631, 642637, 642638, 642641, 642661, 694346 2.7.4.6 nucleoside-diphosphate kinase heart intermediate expression 761777 2.7.4.6 nucleoside-diphosphate kinase heart much lower NME4 mRNA level than the NME1 and NME2 counterparts 761777 2.7.6.2 thiamine diphosphokinase heart - 722081 2.7.7.1 nicotinamide-nucleotide adenylyltransferase heart - 703814 2.7.7.1 nicotinamide-nucleotide adenylyltransferase heart NMNAT1 662419 2.7.7.14 ethanolamine-phosphate cytidylyltransferase heart - 671816, 675978, 693508 2.7.7.14 ethanolamine-phosphate cytidylyltransferase heart very low level of Pcyt2alpha 671816 2.7.7.18 nicotinate-nucleotide adenylyltransferase heart - 703814 2.7.7.19 polynucleotide adenylyltransferase heart - 692501 2.7.7.19 polynucleotide adenylyltransferase heart the protein level is relatively low in the heart 691062 2.7.7.23 UDP-N-acetylglucosamine diphosphorylase heart - 643065 2.7.7.30 fucose-1-phosphate guanylyltransferase heart - 645224 2.7.7.30 fucose-1-phosphate guanylyltransferase heart low expression level 661649 2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase heart - 760903 2.7.7.41 phosphatidate cytidylyltransferase heart - 643312, 662589, 760639 2.7.7.43 N-acylneuraminate cytidylyltransferase heart - 645269 2.7.7.7 DNA-directed DNA polymerase heart - 702387 2.7.7.78 GDP-D-glucose phosphorylase heart highest levels measured in brain and testis (4-8 times higher than in the remaining tissues) 715612 2.7.7.8 polyribonucleotide nucleotidyltransferase heart - 643693, 761702 2.7.7.86 cyclic GMP-AMP synthase heart - 761781 2.7.7.86 cyclic GMP-AMP synthase heart low enzyme expression level 761268 2.7.7.9 UTP-glucose-1-phosphate uridylyltransferase heart - 643748 2.7.8.1 ethanolaminephosphotransferase heart RT-PCR and Northern blot 675276 2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase heart - 645316 2.7.8.15 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase heart - 645359 2.7.8.2 diacylglycerol cholinephosphotransferase heart - 644335 2.7.8.22 1-alkenyl-2-acylglycerol choline phosphotransferase heart - 643767 2.7.8.27 sphingomyelin synthase heart - 668400, 723168 2.7.8.27 sphingomyelin synthase heart high expression of SMS1 mRNA 668729 2.7.8.27 sphingomyelin synthase heart high SMS1 expression level 668729 2.7.8.41 cardiolipin synthase (CMP-forming) heart highly expressed 728087 2.7.8.5 CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase heart - 94808 2.7.9.3 selenide, water dikinase heart weak 645484 2.8.1.1 thiosulfate sulfurtransferase heart atrium and ventricle 645530 2.8.1.2 3-mercaptopyruvate sulfurtransferase heart - 645557, 645561, 645562 2.8.1.4 tRNA uracil 4-sulfurtransferase heart - 643812 2.8.1.7 cysteine desulfurase heart - 645625, 662693 2.8.2.1 aryl sulfotransferase heart - 662758 2.8.2.11 galactosylceramide sulfotransferase heart - 725110 2.8.2.2 alcohol sulfotransferase heart - 760542 2.8.2.2 alcohol sulfotransferase heart low level 760542 2.8.2.20 protein-tyrosine sulfotransferase heart - 645807, 674372, 691163, 705836 2.8.2.23 [heparan sulfate]-glucosamine 3-sulfotransferase 1 heart - 761164 2.8.2.30 [heparan sulfate]-glucosamine 3-sulfotransferase 3 heart - 738961, 761164 2.8.2.35 dermatan 4-sulfotransferase heart - 704398 2.8.2.4 estrone sulfotransferase heart low expression 723909 2.8.2.5 chondroitin 4-sulfotransferase heart - 721534, 760408 2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase heart - 645944, 760812 2.8.3.5 3-oxoacid CoA-transferase heart - 645967, 645968, 645969, 645970, 645971, 645974, 645975, 645978, 645979, 645984, 645986, 645987, 645988, 645989, 645990, 645994, 645995, 672216, 690880, 705523, 723826, 724277, 737420 3.1.1.1 carboxylesterase heart - 665633, 692054 3.1.1.106 O-acetyl-ADP-ribose deacetylase heart - 750645 3.1.1.13 sterol esterase heart - 666549, 714048, 715324 3.1.1.17 gluconolactonase heart - 729350 3.1.1.23 acylglycerol lipase heart - 94261 3.1.1.3 triacylglycerol lipase heart - 664561, 709885, 80849 3.1.1.32 phospholipase A1 heart - 133898, 94308, 94325, 94327 3.1.1.32 phospholipase A1 heart isozyme mPA-PLA1alpha 678494 3.1.1.32 phospholipase A1 heart isozyme PS-PLA1 or PLA1A 678494 3.1.1.32 phospholipase A1 heart low mRNA levels 652297 3.1.1.32 phospholipase A1 heart northern analysis 652226 3.1.1.34 lipoprotein lipase heart - -, 651409, 690344, 690348, 690660, 692187, 693188, 693527, 694184, 729291, 729306, 752181, 80886, 80892, 80898, 80903, 80906, 80916, 80917, 80918 3.1.1.34 lipoprotein lipase heart limb muscle, increase of enzyme activity and mRNA level upon chronic stress 665345 3.1.1.34 lipoprotein lipase heart range of enzyme activity differs up to 6fold among mink, mice, chinese hamster, rat and guinea pig 664839 3.1.1.34 lipoprotein lipase heart when actinomycin is given to fed rats, heparin-releasable lipoprotein lipase activity increases by 160% in 6 h 677471 3.1.1.4 phospholipase A2 heart - 133865, 133870, 133875, 133898, 650888, 653099, 653367, 693127 3.1.1.4 phospholipase A2 heart group IIE and V sPLA2 691654 3.1.1.45 carboxymethylenebutenolidase heart transcript detected by RT-PCR 704653 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase heart - 682621, 80941 3.1.1.5 lysophospholipase heart - 94376, 94389, 94395 3.1.1.53 sialate O-acetylesterase heart - 750712 3.1.1.53 sialate O-acetylesterase heart almost exclusively the nonglycosylated form of the enzyme 94417 3.1.1.56 methylumbelliferyl-acetate deacetylase heart - 646028 3.1.1.67 fatty-acyl-ethyl-ester synthase heart - 646067 3.1.1.67 fatty-acyl-ethyl-ester synthase heart enzyme with FAEES/carboxylesterase activity, structurally different from synthase I-III 646079 3.1.1.67 fatty-acyl-ethyl-ester synthase heart FAEES-III mRNA expression 646069 3.1.1.67 fatty-acyl-ethyl-ester synthase heart low activity 646076 3.1.1.67 fatty-acyl-ethyl-ester synthase heart myocardium 646064, 646069 3.1.1.67 fatty-acyl-ethyl-ester synthase heart ventricular myocardium 646062, 646063, 646065, 646079 3.1.1.7 acetylcholinesterase heart - -, 114132, 749749 3.1.1.7 acetylcholinesterase heart normal and dystrophic heart 114189 3.1.1.79 hormone-sensitive lipase heart - -, 654401, 690342, 714033 3.1.1.8 cholinesterase heart - 654021, 693395, 694365 3.1.2.1 acetyl-CoA hydrolase heart - 664215, 81013, 94468 3.1.2.12 S-formylglutathione hydrolase heart - 80992 3.1.2.18 ADP-dependent short-chain-acyl-CoA hydrolase heart low expression of Acot12 686028 3.1.2.2 palmitoyl-CoA hydrolase heart - 646121, 646149, 646153, 646161, 646163, 646164, 646182, 646200, 651443 3.1.2.2 palmitoyl-CoA hydrolase heart differential regulation of distinct ACSl isoforms at the transcriptional level 663592 3.1.2.2 palmitoyl-CoA hydrolase heart expression of isozyme CTE-I and MTE-I 646203 3.1.2.2 palmitoyl-CoA hydrolase heart moderate expression in male mice. In female mice, mRNA expression of Acot7 isoforms is highest in brain, lung, kidney, heart and ovary 679133 3.1.2.2 palmitoyl-CoA hydrolase heart strong expression 679724 3.1.2.2 palmitoyl-CoA hydrolase heart strong expression of MTE-I, expression of CTE-I and PTE-Ia, no expression of PTE-Ib 651962 3.1.2.2 palmitoyl-CoA hydrolase heart strong expression. ACOT2 is much more strongly expressed than ACOT1 679724 3.1.2.2 palmitoyl-CoA hydrolase heart treatment with a PPARalpha agonist (peroxisome proliferator-activated receptor alpha agonist) increases MTE-1 mRNA, protein expression, and activity and the rate of palmitate export from isolated cardiac mitochondria, suggesting that MTE-I functions to regulate the concentration of long-chain fatty acyl-CoA in the mitochondrial matrix through the generation and export of free fatty acid anions. Thus, upregulation of MTE-I activity may prevent the accumulation of long-chain fatty acyl-CoA in the mitochondrial matrix when the heart is exposed to high levels of fatty acids 681262 3.1.2.20 acyl-CoA hydrolase heart - 646121, 646149, 646153, 646161, 646163, 646164, 646182, 707430, 751912 3.1.2.20 acyl-CoA hydrolase heart expression of isozyme CTE-I and MTE-I 646203 3.1.2.20 acyl-CoA hydrolase heart weak expression 679724 3.1.2.22 palmitoyl[protein] hydrolase heart - 23913, 751572 3.1.2.27 choloyl-CoA hydrolase heart lower enzyme content 646200 3.1.2.3 succinyl-CoA hydrolase heart - 81013 3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase heart - 653127, 94556, 94558 3.1.21.1 deoxyribonuclease I heart low activity 651802 3.1.26.5 ribonuclease P heart - 134413, 134444, 134445 3.1.3.1 alkaline phosphatase heart - 691566 3.1.3.1 alkaline phosphatase heart expressed in heart, demonstrated by RT-PCR 691566 3.1.3.106 2-lysophosphatidate phosphatase heart presence of lipin-1 and lipin-3, lipin-2 is absent. Marked differences in cardiac distribution of PAP1 707381 3.1.3.108 nocturnin heart low expression 755768 3.1.3.11 fructose-bisphosphatase heart low activity 750565 3.1.3.11 fructose-bisphosphatase heart very low enzyme expression level 750565 3.1.3.12 trehalose-phosphatase heart gene expression in 695123 3.1.3.16 protein-serine/threonine phosphatase heart - 134602, 134645, 134646, 654407, 655958, 665243, 677930, 680212, 680236, 708147, 708398, 708457, 709562, 751351, 94873 3.1.3.16 protein-serine/threonine phosphatase heart Aalpha and Abeta subunit are expressed at high levels 654507 3.1.3.16 protein-serine/threonine phosphatase heart high enzyme expression 666301 3.1.3.16 protein-serine/threonine phosphatase heart high expression level 666301 3.1.3.17 [phosphorylase] phosphatase heart - 94685, 94686 3.1.3.2 acid phosphatase heart - 134703 3.1.3.2 acid phosphatase heart trace amounts 652665 3.1.3.25 inositol-phosphate phosphatase heart - 114223, 114233, 680880 3.1.3.27 phosphatidylglycerophosphatase heart - 94808 3.1.3.3 phosphoserine phosphatase heart - 702967 3.1.3.4 phosphatidate phosphatase heart - 134884, 134888, 665805, 680814 3.1.3.4 phosphatidate phosphatase heart approximately fourfold higher in ventricular myocardium than in atrial tissue 677543 3.1.3.4 phosphatidate phosphatase heart fatty liver dystrophy mice contain dramatically lower levels of Mg2+-dependent PAP activity than wild-type mice 680814 3.1.3.4 phosphatidate phosphatase heart lipin-1 709419 3.1.3.4 phosphatidate phosphatase heart LPP-1a predominantly 665805 3.1.3.4 phosphatidate phosphatase heart ventricular and atrial tissue, isozyme PAP-2 677543 3.1.3.4 phosphatidate phosphatase heart ventricular and atrial tissue, isozymes PAP-1 and PAP-2 677543 3.1.3.42 [glycogen-synthase-D] phosphatase heart - 655957, 94866 3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase heart - 695493, 698844, 94880, 94881, 94883, 94884, 94886, 94887, 94888, 94889, 94890, 94892, 94893, 94894, 94898, 94901, 94903, 94904, 94906, 94908, 94909, 94910, 94912, 94913, 94918 3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase heart high level of isoform PDP1 and PDP2 650946 3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase heart PDP1 642159 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase heart - 663563, 665582, 729519, 730008, 94925, 94942, 94949 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase heart cardiac isoform 714090 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase heart isozyme PFKFB2 663935 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase heart specific isozyme PFKFB2 663935 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase heart tissue-specific isoform, overview 650931 3.1.3.48 protein-tyrosine-phosphatase heart - 694827, 94978, 94985 3.1.3.5 5'-nucleotidase heart - 650886, 677295, 680180, 691398, 691839, 95042, 95053, 95058, 95065, 95069, 95070 3.1.3.5 5'-nucleotidase heart high activity 652095 3.1.3.5 5'-nucleotidase heart left heart ventricle 693953 3.1.3.5 5'-nucleotidase heart sarcolemma 95040 3.1.3.5 5'-nucleotidase heart ventricular myocardium 709210 3.1.3.52 [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase heart - 732061 3.1.3.53 [myosin-light-chain] phosphatase heart - 715547, 749538 3.1.3.53 [myosin-light-chain] phosphatase heart coronary artery smooth muscle 666160 3.1.3.53 [myosin-light-chain] phosphatase heart expression of MYPT1 and MYPT2, the 2 isoforms of the large subunit 646371 3.1.3.53 [myosin-light-chain] phosphatase heart portal vein, expression of MYPT 1 subunit increases 2fold between postnatal days 6 and 12 with similar increase in enzyme activity. MYPT 1 switches from leucine-zipper positive to leucine-zipper negative isoforms, concordant with a switch from sensitive to resisitant to cGMP-mediated vascular relaxation 666095 3.1.3.56 inositol-polyphosphate 5-phosphatase heart PIPP enzyme 646399 3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase heart - 646415 3.1.3.62 multiple inositol-polyphosphate phosphatase heart - 646435 3.1.3.62 multiple inositol-polyphosphate phosphatase heart mRNA expression 646439 3.1.3.64 phosphatidylinositol-3-phosphatase heart - 732086 3.1.3.64 phosphatidylinositol-3-phosphatase heart adapter subunit 3-PAP mRNA, 2 transcripts of 5.5 and 2.5 kb 646450 3.1.3.7 3'(2'),5'-bisphosphate nucleotidase heart - 728931 3.1.3.74 pyridoxal phosphatase heart - 669164 3.1.3.75 phosphoethanolamine/phosphocholine phosphatase heart low expression, 5.67fold higher than in liver 680993 3.1.3.9 glucose-6-phosphatase heart - 134933, 134945, 665603 3.1.3.9 glucose-6-phosphatase heart expression of G6PC3 isoform 651331 3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase heart - 750259 3.1.3.99 IMP-specific 5'-nucleotidase heart - 735626 3.1.3.B4 phosphatidylinositol-4-phosphate phosphatase heart low expression 751173 3.1.4.1 phosphodiesterase I heart - 208367, 697620 3.1.4.1 phosphodiesterase I heart heart left ventricle, expression of isoforms NPP2 and NPP3, not NPP1. NPP3 shows the highest abundance 681901 3.1.4.11 phosphoinositide phospholipase C heart - 135126, 285216, 670440 3.1.4.11 phosphoinositide phospholipase C heart coronary artery smooth muscle 135124 3.1.4.11 phosphoinositide phospholipase C heart expression of PLCepsilon -, 650986 3.1.4.11 phosphoinositide phospholipase C heart highest expression of PLC-eta detected in heart. PLC-delta3 is present in heart. PLC-delta1 is present in high abundancy in the brain, heart, lung, skeletal muscle and testis 691473 3.1.4.11 phosphoinositide phospholipase C heart PLC-epsilon, most abundantly in 649330 3.1.4.12 sphingomyelin phosphodiesterase heart - 652079 3.1.4.12 sphingomyelin phosphodiesterase heart coronary arterial endothelial cells 677602 3.1.4.12 sphingomyelin phosphodiesterase heart isozyme nSMase3 678375 3.1.4.12 sphingomyelin phosphodiesterase heart neutral sphingomyelinase 681494 3.1.4.13 serine-ethanolaminephosphate phosphodiesterase heart trace amounts 81109 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase heart - 135228, 135236, 135264, 135266, 135274, 692697, 716347, 752065 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase heart 10-20% of activity found in brain 651468 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase heart fetal and adult 135271 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase heart PDE1 668987 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase heart PDE11A4, weak antibody staining of neuronal cells within parasympathetic ganglia in the heart 668988 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase heart PDE2 668987 3.1.4.2 glycerophosphocholine phosphodiesterase heart - 752186 3.1.4.2 glycerophosphocholine phosphodiesterase heart low activity 95135 3.1.4.3 phospholipase C heart isoform PLCG1 750568 3.1.4.3 phospholipase C heart lesser expression of NPP6 665632 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase heart - 649549, 650342, 651412, 716347 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase heart enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied human right ventricle 679253 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase heart enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied right ventricle 679253 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase heart low gene expression 691533 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase heart whole myocardium from failing hearts have 50% lower PDE5A expression and 30% less total and EMD82639-inhibitable cGMP-PDE activity 651222 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase heart - 135422, 750212, 751698 3.1.4.4 phospholipase D heart - 650338, 666150, 666213, 679088, 730316 3.1.4.4 phospholipase D heart atrial myocardium 652960 3.1.4.4 phospholipase D heart transient PLD1 expression during heart development in embryos, PLD1 levels increase at 0 and 3 days postpartum, and decline gradually beginning 7 days after birth, immunohistochemic analysis, overview 709738 3.1.4.40 CMP-N-acylneuraminate phosphodiesterase heart - 135474 3.1.4.46 glycerophosphodiester phosphodiesterase heart - 681847 3.1.4.46 glycerophosphodiester phosphodiesterase heart GDE2 mRNA 665036 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase heart - 135264, 684819, 684821, 687488, 689817, 694262, 716347 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase heart highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order 689816 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase heart lowest expression in heart 691716 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase heart neonatal cardiac myocyte 730102 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase heart PDE7A2 689817 3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D heart - 666213, 708109, 708501, 708982, 710115 3.1.6.1 arylsulfatase (type I) heart poor expression 730056 3.1.6.12 N-acetylgalactosamine-4-sulfatase heart - 135556 3.1.6.13 iduronate-2-sulfatase heart - 691079 3.1.6.13 iduronate-2-sulfatase heart adult 709793 3.1.6.4 N-acetylgalactosamine-6-sulfatase heart - 681953 3.13.2.1 adenosylhomocysteinase heart - 753615 3.13.2.1 adenosylhomocysteinase heart very low level -, 137135 3.2.1.1 alpha-amylase heart - 679313 3.2.1.106 mannosyl-oligosaccharide glucosidase heart - 170969 3.2.1.107 protein-glucosylgalactosylhydroxylysine glucosidase heart - -, 208432 3.2.1.128 glycyrrhizin hydrolase heart - 286343 3.2.1.130 glycoprotein endo-alpha-1,2-mannosidase heart - 665064 3.2.1.166 heparanase heart - 694846 3.2.1.17 lysozyme heart - 729763, 750570, 750571 3.2.1.17 lysozyme heart constitutively expressed 677863 3.2.1.18 exo-alpha-sialidase heart - 654541 3.2.1.18 exo-alpha-sialidase heart low expression of Neu-2 654541 3.2.1.18 exo-alpha-sialidase heart significant expression of isoform Neu3d 729800 3.2.1.183 UDP-N-acetylglucosamine 2-epimerase (hydrolysing) heart - 721653 3.2.1.207 mannosyl-oligosaccharide alpha-1,3-glucosidase heart low expression -, 732369 3.2.1.22 alpha-galactosidase heart - 171251 3.2.1.33 amylo-alpha-1,6-glucosidase heart - 680002 3.2.1.35 hyaluronoglucosaminidase heart - 649571, 664710 3.2.1.35 hyaluronoglucosaminidase heart high expression 664710 3.2.1.35 hyaluronoglucosaminidase heart low expression 664710 3.2.1.45 glucosylceramidase heart - 749981, 751699 3.2.1.49 alpha-N-acetylgalactosaminidase heart - 707033 3.2.1.50 alpha-N-acetylglucosaminidase heart - 208687 3.2.1.51 alpha-L-fucosidase heart - 208735 3.2.1.76 L-iduronidase heart low activity 171573 3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase heart - 657197 3.2.2.19 [protein ADP-ribosylarginine] hydrolase heart - 137040, 137041, 137045, 750380 3.2.2.21 DNA-3-methyladenine glycosylase II heart - 646881 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase heart - 326411 3.3.2.10 soluble epoxide hydrolase heart - -, 663275, 683355, 695933, 697521, 700360, 701008, 707067, 708022, 708253, 709214, 709248, 709564, 709683, 710044, 731352, 731877 3.3.2.2 lysoplasmalogenase heart - 137152 3.3.2.6 leukotriene-A4 hydrolase heart - 709480 3.3.2.9 microsomal epoxide hydrolase heart - 208880, 208881, 663275, 699759 3.3.2.9 microsomal epoxide hydrolase heart mEH is particularly concentrated in the heart 700587 3.4.11.1 leucyl aminopeptidase heart - 35908 3.4.11.14 cytosol alanyl aminopeptidase heart - 681000 3.4.11.14 cytosol alanyl aminopeptidase heart lowest activity 700450 3.4.11.2 membrane alanyl aminopeptidase heart - 664240, 666534 3.4.11.2 membrane alanyl aminopeptidase heart expression only in the early developmental stages 664725 3.4.11.2 membrane alanyl aminopeptidase heart mouse model of cardiac angiogenesis 683108 3.4.11.21 aspartyl aminopeptidase heart - 137168, 666534, 681000 3.4.11.3 cystinyl aminopeptidase heart - 667811, 668309, 670271, 753121 3.4.11.3 cystinyl aminopeptidase heart low activity 668309 3.4.11.6 aminopeptidase B heart - 665109, 666534, 666799 3.4.11.6 aminopeptidase B heart cardiac ventricular fibroblastic cell 664535 3.4.11.7 glutamyl aminopeptidase heart - -, 663609, 753895 3.4.11.7 glutamyl aminopeptidase heart low enzyme level -, 752443 3.4.11.9 Xaa-Pro aminopeptidase heart - 36043 3.4.13.18 cytosol nonspecific dipeptidase heart - 137183 3.4.13.19 membrane dipeptidase heart - 678065 3.4.13.19 membrane dipeptidase heart high expression of membrane-bound dipeptidase-1 and membrane-bound dipeptidase-2, expression of membrane-bound dipeptidase-3 is not detectable 647113 3.4.13.9 Xaa-Pro dipeptidase heart - 683958 3.4.14.1 dipeptidyl-peptidase I heart - 696096 3.4.14.1 dipeptidyl-peptidase I heart highest expression level in heart 697447 3.4.14.10 tripeptidyl-peptidase II heart - 647141 3.4.14.2 dipeptidyl-peptidase II heart - 651779, 95240 3.4.14.5 dipeptidyl-peptidase IV heart in heart DPIV represents 71% of the total Gly-L-Pro-4-nitroanilide-hydrolyzing activity 697386 3.4.14.9 tripeptidyl-peptidase I heart - 647183, 678513, 696096 3.4.15.1 peptidyl-dipeptidase A heart - 679321, 679469, 695446, 707024, 708183, 709653, 710222, 81223, 81235, 81283 3.4.15.1 peptidyl-dipeptidase A heart heart membrane, ACE activity is significantly higher in hearts of young Zucker rats than in those of Sprague-Dawley rats 710097 3.4.15.1 peptidyl-dipeptidase A heart mice with angiotensin converting enzyme expression only in the heart show atria enlargement and electrical conduction defects but normal ventricular function 680175 3.4.16.5 carboxypeptidase C heart embryonic 665905 3.4.17.1 carboxypeptidase A heart - 36321, 679706 3.4.17.10 carboxypeptidase E heart - 81307 3.4.17.10 carboxypeptidase E heart low activity 81289 3.4.17.12 carboxypeptidase M heart - 696990 3.4.17.12 carboxypeptidase M heart coronary vascular bed 683099 3.4.17.12 carboxypeptidase M heart CPM mRNA expression is very low in the human heart 697395 3.4.17.22 metallocarboxypeptidase D heart - 28967, 28971 3.4.17.23 angiotensin-converting enzyme 2 heart - 659147, 668220, 668528, 668892, 669404, 677475, 678102, 679072, 679705, 679706, 680099, 680103, 694170, 707036, 708141, 708649, 708684, 710214, 762703, 763217 3.4.17.23 angiotensin-converting enzyme 2 heart 12-day administration of agents that either inhibit the synthesis of circulating angiotensin II or block the activity of angiotensin II at the AT1 receptor induce an increase in cardiac ACE2 mRNA, accompanied by increases in cardiac membrane ACE2 activity in rats medicated with either losartan or both losartan and lisinopril 668266 3.4.17.23 angiotensin-converting enzyme 2 heart about 35% of the ACE2 gene expression in kidney cortex 668896 3.4.17.23 angiotensin-converting enzyme 2 heart elevated expression in a rat model with chronic heart failure 731092 3.4.17.23 angiotensin-converting enzyme 2 heart the endothelium-bound carboxypeptidase is expressed in the heart and kidney 694351 3.4.17.23 angiotensin-converting enzyme 2 heart the enzyme is upregulated in cardiovascular disease 695418 3.4.17.23 angiotensin-converting enzyme 2 heart vascular endothelial cells 754646 3.4.18.1 cathepsin X heart - 691910 3.4.19.1 acylaminoacyl-peptidase heart - 667841, 731801, 95254 3.4.19.12 ubiquitinyl hydrolase 1 heart - 698156 3.4.19.12 ubiquitinyl hydrolase 1 heart usp21 gene expression, high content 646104 3.4.19.14 leukotriene-C4 hydrolase heart - 717760 3.4.19.3 pyroglutamyl-peptidase I heart high levels of of soluble PGP I activity during the initial moments of development, in the fourth postnatal day activity starts to decrease until adulthood. Activity of the particulate form shows lowest values, during the first 20 days of life a significant decrease takes place, from this moment activity remains constant. No significant changes in activity of the particulate form 682806 3.4.19.6 pyroglutamyl-peptidase II heart atrium and ventricle 753360 3.4.21.105 rhomboid protease heart - 710343 3.4.21.106 hepsin heart transmembrane isoform only 672315 3.4.21.108 HtrA2 peptidase heart - 651080, 668267, 697154 3.4.21.108 HtrA2 peptidase heart neonatal ventricular cardiomyocytes 668267 3.4.21.109 matriptase heart - 657796 3.4.21.118 kallikrein 8 heart - 707620 3.4.21.20 cathepsin G heart - 683354 3.4.21.21 coagulation factor VIIa heart - 755589 3.4.21.26 prolyl oligopeptidase heart - 653857, 683926, 692563, 708809 3.4.21.32 brachyurin heart - 731881 3.4.21.32 brachyurin heart low expression level 731830 3.4.21.34 plasma kallikrein heart prekallikrein expression 653115 3.4.21.35 tissue kallikrein heart - 647495, 677844 3.4.21.39 chymase heart - 655319, 656450, 656451, 679069, 680901, 697152, 699756, 709290 3.4.21.39 chymase heart interstitial fluid from left ventricle 709272 3.4.21.45 complement factor I heart - 753374 3.4.21.45 complement factor I heart expression shown by RT-PCR 708534 3.4.21.46 complement factor D heart - 683526, 753616 3.4.21.46 complement factor D heart high mRNA expression determined by real-time RT-PCR 708533 3.4.21.46 complement factor D heart moderate expression 753602 3.4.21.53 Endopeptidase La heart - 677574, 697889, 752805 3.4.21.59 Tryptase heart - 683455 3.4.21.6 coagulation factor Xa heart - 731756 3.4.21.61 Kexin heart - 753290 3.4.21.61 Kexin heart gene expression but no enzyme protein content -, 731229 3.4.21.69 Protein C (activated) heart - -, 732697 3.4.21.7 plasmin heart - 732904 3.4.21.73 u-Plasminogen activator heart - 683623 3.4.21.73 u-Plasminogen activator heart hearts with end-stage failure and fibrosis have macrophage accumulation and elevated plasminogen activator activity, mechanisms that link macrophage accumulation and plasminogen activator activity with cardiac fibrosis, overview 683623 3.4.21.92 Endopeptidase Clp heart - 697889 3.4.21.B1 hyaluronan-binding serine protease heart - 731684 3.4.21.B12 prostase heart - 680174 3.4.21.B25 PACE4 proprotein convertase heart - 673909 3.4.21.B26 proprotein convertase 5 heart PC5A dominates 675967 3.4.21.B41 kallikrein 10 heart barely detectable gene expression 647362 3.4.21.B42 hippostasin heart brain-type isozyme 647365 3.4.21.B5 mast cell protease 5 heart - 699756 3.4.22.1 cathepsin B heart - -, 709745, 733698, 733892 3.4.22.1 cathepsin B heart lowest expression in heart 717519 3.4.22.15 cathepsin L heart - 680861, 717615 3.4.22.15 cathepsin L heart high expression level 753596 3.4.22.27 cathepsin S heart - 668394, 701151, 753606 3.4.22.27 cathepsin S heart low activity 647982 3.4.22.36 caspase-1 heart low activity -, 647460 3.4.22.38 cathepsin K heart - 696041, 708216, 732583 3.4.22.38 cathepsin K heart at 3 h post-challenge with Aeromonas hydrophila, the cathepsins K expression is seen only in the heart 708535 3.4.22.38 cathepsin K heart medium activity 30368 3.4.22.41 cathepsin F heart - 137260, 717638 3.4.22.41 cathepsin F heart high expression 708220 3.4.22.42 cathepsin O heart - 137267 3.4.22.43 cathepsin V heart - 707906, 753828 3.4.22.52 calpain-1 heart - 644005, 707065, 717201, 718096, 753389 3.4.22.53 calpain-2 heart - 644005, 668262, 709566 3.4.22.55 caspase-2 heart - -, 647460, 663875, 664548 3.4.22.56 caspase-3 heart - -, 647460, 717617, 717792, 753607 3.4.22.56 caspase-3 heart geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity 680420 3.4.22.56 caspase-3 heart no differences between caspase 3 activities in the hearts from mice without infarcts and caspase 3 activities in hearts from mice with infarction or ischemia -, 697855 3.4.22.57 caspase-4 heart - 647460, 647731 3.4.22.59 caspase-6 heart - 647460, 752585 3.4.22.60 caspase-7 heart - 647460 3.4.22.61 caspase-8 heart - -, 647436, 664711, 699625, 717282 3.4.22.61 caspase-8 heart caspase-8 activity is similar in healthy and myocardial ischemic hearts -, 697855 3.4.22.62 caspase-9 heart - 666835 3.4.22.62 caspase-9 heart high expression level 717527 3.4.22.63 caspase-10 heart weak expression 679931 3.4.22.64 caspase-11 heart - -, 647460 3.4.22.B25 calpain 5 heart weak expression 663847 3.4.22.B28 calpain 8 heart - 648094 3.4.22.B29 calpain 9 heart - 664555 3.4.22.B30 calpain 10 heart - 648105 3.4.22.B37 calpain B heart - 665858 3.4.22.B71 SENP2 peptidase heart - -, 732158 3.4.22.B73 SENP5 peptidase heart significant increase in the level of enzyme SENP5 in human idiopathic failing hearts 732349 3.4.23.45 memapsin 1 heart - 638894, 638900 3.4.23.5 cathepsin D heart - 698022, 712050, 731700, 731831 3.4.23.5 cathepsin D heart cardiomyocyte primary culture 649424 3.4.23.5 cathepsin D heart weak expression 753378 3.4.23.B24 signal peptide peptidase heart - 752819 3.4.24.11 neprilysin heart - 753262, 754689 3.4.24.14 procollagen N-endopeptidase heart - 753779 3.4.24.14 procollagen N-endopeptidase heart upregulated expression of ADAMTS2 in failing human hearts, expression analysis of ADAMTS2 in human heart samples from patients with dilated cardiomyopathy and from healthy donors 753779 3.4.24.14 procollagen N-endopeptidase heart upregulated expression of ADAMTS2 in hypertrophic murine hearts 753779 3.4.24.15 thimet oligopeptidase heart - 37064 3.4.24.16 neurolysin heart - 37069, 668828 3.4.24.16 neurolysin heart low activity 37080 3.4.24.19 procollagen C-endopeptidase heart mTld and BMP-1 668838 3.4.24.23 matrilysin heart - 683356, 708150, 709702 3.4.24.23 matrilysin heart expression analysis in hearts after transplantation, overview 683742 3.4.24.24 gelatinase A heart - 683045, 683846, 752865 3.4.24.24 gelatinase A heart low expression 753613 3.4.24.35 gelatinase B heart - 697726 3.4.24.35 gelatinase B heart enzyme activity and expression analysis, overview 683111 3.4.24.56 insulysin heart - 683567, 710682 3.4.24.59 mitochondrial intermediate peptidase heart - 668830 3.4.24.61 nardilysin heart - 31365 3.4.24.7 interstitial collagenase heart the MMP-1 levels are altered in the left ventricle and serum in case of hypertrophy through hyperthyroid conditions with 3,5,3'-triiodo-L-thyroine or dexamethasone application, tissue distribution, overview 683845 3.4.24.71 endothelin-converting enzyme 1 heart - 683965, 733056 3.4.24.71 endothelin-converting enzyme 1 heart no increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse -, 699415 3.4.24.71 endothelin-converting enzyme 1 heart quantitative immunohistochemic analysis of enzyme distribution in autopsy specimen of post-percutaneous coronary intervention, PCI, sites and restenotic sites, the enzyme is detectable in the first 3 months after PCI, overview 683725 3.4.24.79 pappalysin-1 heart - 683359, 683969 3.4.24.79 pappalysin-1 heart coronary artery smooth muscle cells 683504 3.4.24.80 membrane-type matrix metalloproteinase-1 heart MT1-MMP is increased in myocardial ischemia and reperfusion, myocardial, interstitial enzyme, microdialysis analysis, overview 677477 3.4.24.82 ADAMTS-4 endopeptidase heart mRNA is present in heart tissue 638955 3.4.24.84 Ste24 endopeptidase heart - 670378 3.4.24.86 ADAM 17 endopeptidase heart - 638981 3.4.24.87 ADAMTS13 endopeptidase heart - 679396 3.4.24.87 ADAMTS13 endopeptidase heart enzyme expression 650709 3.4.24.B11 ADAMTS1 endopeptidase heart - 651941, 754567 3.4.24.B11 ADAMTS1 endopeptidase heart low expression level 651525 3.4.24.B11 ADAMTS1 endopeptidase heart tissue containing a 62 kDa fragment of ADAMTS-1 667103 3.4.24.B14 neprilysin-2 heart isozymes SEP and SEPDELTA 651958 3.4.24.B4 matrix metalloproteinase-13 heart - 711825 3.4.24.B9 ADAM9 endopeptidase heart expression of full length and short enzyme form 649598 3.4.25.1 proteasome endopeptidase complex heart - 137336, 649426, 684668, 686124 3.4.25.1 proteasome endopeptidase complex heart specific activities of the three standard proteasome subtypes II-2, II-3, and II-4 from rat heart exhibit high chymotrypsin-like activity, whereas the trypsin-like activity of these three subtypes account for only 1-2% compared with the chymotrypsin-like activity, their caspase-like activities overexceed the latter by 35-50%, overview 711690 3.4.99.B1 RCE1 heart - 669285 3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase heart less expression 710809 3.5.1.12 biotinidase heart - 171917, 669619 3.5.1.15 aspartoacylase heart - -, 208998, 209002 3.5.1.17 acyl-lysine deacylase heart - 171965 3.5.1.2 glutaminase heart - 209015, 209028, 209031 3.5.1.2 glutaminase heart GLS1 669950 3.5.1.21 N-acetyl-beta-alanine deacetylase heart - 171973 3.5.1.23 ceramidase heart - 669761, 711799, 733093, 752416 3.5.1.23 ceramidase heart high CDase expression 656010 3.5.1.23 ceramidase heart high expression level of neutral ceramidase 733408 3.5.1.23 ceramidase heart high expression of neutral ceramidase 719197 3.5.1.3 omega-amidase heart - 288893 3.5.1.31 formylmethionine deformylase heart - 393796 3.5.1.4 amidase heart FAAH-2 687528 3.5.1.48 acetylspermidine deacetylase heart - 172046 3.5.1.48 acetylspermidine deacetylase heart 10% activity of that in liver 172054 3.5.1.6 beta-ureidopropionase heart - 172056, 172069 3.5.1.68 N-formylglutamate deformylase heart moderate activity -, 209222 3.5.1.92 pantetheine hydrolase heart - 659867 3.5.1.98 histone deacetylase heart - 680610, 680620, 697354 3.5.1.99 fatty acid amide hydrolase heart highly expressed 687528 3.5.2.17 hydroxyisourate hydrolase heart - 733937 3.5.2.2 dihydropyrimidinase heart - 209292 3.5.2.3 dihydroorotase heart - 697580 3.5.3.1 arginase heart - 752912 3.5.3.1 arginase heart heart homogenate 670700 3.5.3.1 arginase heart normal and hypertrophied feline myocardium, both isoforms arginase-I and arginase-II in crude myocardial homogenate. Arginase-I is downregulated in left ventricular hypertrophy 667157 3.5.3.1 arginase heart tissues grouped based on their expression as follows, from lowest to highest: 1. intestine; 2. adipose tissue, spleen, blood, head kidney, scales and tail fin; 3. adipose fin, brain, heart, gonad, muscle and thymus; 4. skin; 5. gills and liver; 6. posterior kidney 753605 3.5.3.1 arginase heart tissues grouped based on their expression as follows, from lowest to highest: 1. liver; 2. intestine and tail fin; 3. adipose tissue, spleen, gills and scales; 4. adipose fin, skin, blood, posterior kidney, gonad, head kidney and thymus; 5. heart; 6. brain and muscle 753605 3.5.3.1 arginase heart tissues grouped based on their expression as follows, from lowest to highest: 1. liver; 2. tail fin; 3. adipose tissue, intestine, posterior kidney, head kidney, heart and skin; 4. blood, gonad, scales, gills, spleen, brain, thymus; 5. adipose fin and muscle 753605 3.5.3.1 arginase heart tissues grouped based on their expression as follows, from lowest to highest: 1. tail fin, intestine and scales; 2. adipose tissue, spleen and head kidney; 3. adipose fin and posterior kidney; 4. blood, muscle and thymus; 5. gills; 6. brain, skin, heart, gonad and liver 753605 3.5.3.15 protein-arginine deiminase heart - 733680 3.5.3.18 dimethylargininase heart - 697831, 698209, 720369 3.5.3.18 dimethylargininase heart DDAH II is highly expressed 288965 3.5.3.18 dimethylargininase heart DDAH1 RNA is expressed in the left ventricle, cardiac outflow tract and developing vasculature. DDAH2 expression is seen in the developing left ventricle and cardiac outflow tract, and additionally in the peripheral nervous system 712183 3.5.3.18 dimethylargininase heart in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS 710771 3.5.4.16 GTP cyclohydrolase I heart - -, 718548, 720858 3.5.4.16 GTP cyclohydrolase I heart cardiac GTP cyclohydrolase 1 is degraded in remodeled hearts after myocardial infarction, concomitant with increases in the thickness of interventricular septum, interstitial fibrosis, and phosphorylated p38 mitogen-activated protein kinase and decreases in left ventricular anterior wall thickness, cardiac contractility, tetrahydrobiopterin, the dimers of nitric oxide synthase, sarcoplasmic reticulum Ca2+ release, and the expression of sarcoplasmic reticulum Ca2+ handling proteins 758404 3.5.4.3 guanine deaminase heart - 209590, 209598 3.5.4.36 mRNA(cytosine6666) deaminase heart low level 719788 3.5.4.4 adenosine deaminase heart - 667361 3.5.4.4 adenosine deaminase heart atrium 689374 3.5.4.5 cytidine deaminase heart - 209533, 209648 3.5.4.6 AMP deaminase heart - 209690, 209701, 209705, 209711, 209712, 700512 3.5.4.6 AMP deaminase heart cardiac myocytes 209708 3.5.4.6 AMP deaminase heart potential major role for increased AMP deaminase activity in diastolic dysfunction 669999 3.6.1.1 inorganic diphosphatase heart - 685433 3.6.1.1 inorganic diphosphatase heart high expression level of isozyme PPase2 668747 3.6.1.1 inorganic diphosphatase heart higher expression level of isozyme PPase1 668747 3.6.1.10 endopolyphosphatase heart low activity 209837 3.6.1.12 dCTP diphosphatase heart enzyme is ubiquitously expressed. Expression is highest in the liver and heart, and to a lesser extent the salivary gland 722230 3.6.1.13 ADP-ribose diphosphatase heart - 209946, 655991 3.6.1.14 adenosine-tetraphosphatase heart - 209871 3.6.1.15 nucleoside-triphosphate phosphatase heart expression in 696153 3.6.1.28 thiamine-triphosphatase heart - 210006, 210007, 655198, 668963 3.6.1.28 thiamine-triphosphatase heart 217 nmol per min per mg of wet weight 655198 3.6.1.45 UDP-sugar diphosphatase heart - 711078 3.6.1.5 apyrase heart - 210150, 696153 3.6.1.5 apyrase heart cardiac vasulature, endothelium, endocardium and to a lesser extent in vascular smooth muscle 655122 3.6.1.5 apyrase heart ventricle, detected by immunoblotting in smooth muscle cells and endothelial cells 210157 3.6.1.5 apyrase heart ventricle, sarcolemma 210158 3.6.1.52 diphosphoinositol-polyphosphate diphosphatase heart - 668226 3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming) heart - 714610 3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming) heart low activity 714610 3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase heart - 716218 3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase heart Dcp2 is present in embryonic brain, heart, liver, and kidney. A substantial decrease of Dcp2 is evident in heart, liver, and kidney at birth and a continual decrease to undetectable levels in the adult 716218 3.6.1.7 acylphosphatase heart - 246781, 246800 3.6.1.7 acylphosphatase heart cardiac muscle 246793 3.6.1.7 acylphosphatase heart common-type enzyme 246773 3.6.1.74 mRNA 5'-phosphatase heart - 760471 3.6.1.9 nucleotide diphosphatase heart - -, 720117, 757130 3.6.1.9 nucleotide diphosphatase heart intermediate NPP1 enzyme expression 696406 3.6.5.1 heterotrimeric G-protein GTPase heart Go-alpha subunit 644099 3.6.5.2 small monomeric GTPase heart - 720356, 734348, 756748 3.6.5.2 small monomeric GTPase heart barely detectable mRNA expression 644112 3.7.1.3 kynureninase heart - 289278 3.9.1.3 phosphohistidine phosphatase heart - 735627, 736044, 736550 4.1.1.12 aspartate 4-decarboxylase heart - 3962 4.1.1.15 glutamate decarboxylase heart - 700110 4.1.1.17 ornithine decarboxylase heart - 4009, 680217, 709921, 713733 4.1.1.17 ornithine decarboxylase heart basal ornithine decarboxylase activity in isolated left atria shows differences in the four groups of animals studied, being higher in males than estrogenized females, and increased in both sexes by castration, though not significantly changed in females 697772 4.1.1.28 aromatic-L-amino-acid decarboxylase heart - 693382 4.1.1.28 aromatic-L-amino-acid decarboxylase heart no expression of ddc gene 694106 4.1.1.28 aromatic-L-amino-acid decarboxylase heart novel imprinted dopa decarbylase gene on chromosome 11 is a 2kb transcript variant that initiates from an alternative first exon in intron 1 of the canonical Ddc transcript, it is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Imprinted gene expression is progressively downregulated in the heart during postnatal development and occurs only at low basal levels in the adult heart. 694156 4.1.1.28 aromatic-L-amino-acid decarboxylase heart right atrium, left atrium, right ventriculum, left ventriculum -, 666464 4.1.1.29 sulfinoalanine decarboxylase heart - 746903 4.1.1.29 sulfinoalanine decarboxylase heart strong expression 746903 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP) heart - 680841 4.1.1.33 diphosphomevalonate decarboxylase heart - 650498, 715787 4.1.1.33 diphosphomevalonate decarboxylase heart low activity 650486 4.1.1.36 phosphopantothenoylcysteine decarboxylase heart - 4408 4.1.1.37 uroporphyrinogen decarboxylase heart - 4423 4.1.1.40 hydroxypyruvate decarboxylase heart - 4542 4.1.1.42 carnitine decarboxylase heart - 4555 4.1.1.9 malonyl-CoA decarboxylase heart - 4844, 4849, 4860, 681284, 691657, 694551, 726656 4.1.1.9 malonyl-CoA decarboxylase heart high expression level 727260 4.1.1.90 peptidyl-glutamate 4-carboxylase heart - 715064 4.1.1.90 peptidyl-glutamate 4-carboxylase heart expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues 697786 4.1.2.13 fructose-bisphosphate aldolase heart - 4910, 4933 4.1.2.27 sphinganine-1-phosphate aldolase heart - 5112, 5119, 5122, 682957, 713721, 748220 4.1.2.27 sphinganine-1-phosphate aldolase heart low expression 713688 4.1.2.27 sphinganine-1-phosphate aldolase heart mRNA expression is temporally regulated during embryonal development 663853 4.1.3.4 hydroxymethylglutaryl-CoA lyase heart - 5364, 5367 4.1.3.6 citrate (pro-3S)-lyase heart - 649579 4.1.99.13 (6-4)DNA photolyase heart - 747608 4.1.99.3 deoxyribodipyrimidine photo-lyase heart - -, 664901, 747608 4.2.1.1 carbonic anhydrase heart - 652546, 665834, 714462, 748270 4.2.1.1 carbonic anhydrase heart carbonic anhydrase XIV 679413 4.2.1.1 carbonic anhydrase heart contains carbonic anhydrase I, II and III 33541 4.2.1.1 carbonic anhydrase heart low activity 665835 4.2.1.1 carbonic anhydrase heart very low expression level of isozyme pentraxin-carbonic anhydrase 748840 4.2.1.11 phosphopyruvate hydratase heart - 33611, 703811 4.2.1.11 phosphopyruvate hydratase heart back and hind legs 3247 4.2.1.11 phosphopyruvate hydratase heart enolase I and III 33604 4.2.1.17 enoyl-CoA hydratase heart - 33713, 5866 4.2.1.2 fumarate hydratase heart - 33728, 33745, 33750, 33752, 33753, 33755, 33759, 33760, 33761, 650370, 680069, 703151, 715610 4.2.1.3 aconitate hydratase heart - -, 33784, 33788, 33789, 33796, 33798, 33799, 33800, 33801, 33802, 33805, 33813, 650198, 677832, 679969, 681626, 696168, 697220, 747087 4.2.1.3 aconitate hydratase heart aconitase-specific activity increases by 12% at 2% O2 compared to 21% O2 729779 4.2.1.3 aconitate hydratase heart changes in enzyme activity in myocardial ischemia are coupled to accumulation of citrate, overview 696162 4.2.1.47 GDP-mannose 4,6-dehydratase heart - 5732 4.2.1.48 D-glutamate cyclase heart - 749348 4.2.1.48 D-glutamate cyclase heart highly expressed in the mitochondrial matrix in the heart 746927 4.2.1.74 medium-chain-enoyl-CoA hydratase heart - 5866, 5868, 5869, 698680 4.2.1.93 ATP-dependent NAD(P)H-hydrate dehydratase heart lowest enzyme content 747020 4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase heart - 648681 4.3.1.20 erythro-3-hydroxy-L-aspartate ammonia-lyase heart - 210868 4.3.2.1 argininosuccinate lyase heart - 650800, 709968 4.3.2.2 adenylosuccinate lyase heart - 716175 4.3.2.5 peptidylamidoglycolate lyase heart - 648703 4.3.2.9 gamma-glutamylcyclotransferase heart - 687744, 705761 4.4.1.1 cystathionine gamma-lyase heart - 690376, 695134 4.4.1.16 selenocysteine lyase heart - 648740, 648745, 648747, 648750 4.4.1.16 selenocysteine lyase heart low activity 648740 4.4.1.17 Holocytochrome-c synthase heart - 691983 4.4.1.20 leukotriene-C4 synthase heart - 644496, 644508, 664566 4.4.1.5 lactoylglutathione lyase heart - 37413, 729179 4.6.1.1 adenylate cyclase heart - -, 34788, 34791, 34795, 34797, 34818, 679659, 680097, 681603, 691723, 691835, 693180, 693847, 694874, 714051 4.6.1.1 adenylate cyclase heart cardiac isozyme AC5 -, 692815 4.6.1.1 adenylate cyclase heart expression of isozyme adenylyl cyclase VI, ACVI, at the left ventricular 692782 4.6.1.1 adenylate cyclase heart high activity in sinoatrial nodal cells, and less in ventricular myocytes 693052 4.6.1.1 adenylate cyclase heart isoforms AC3, AC5, and AC7 are detected in heart, AC5 is an important adenylyl cyclase isoform in heart 709677 4.6.1.1 adenylate cyclase heart isozyme AC2 694405 4.6.1.1 adenylate cyclase heart isozyme AC2 is localized to the same structures in adult mice 691717 4.6.1.1 adenylate cyclase heart isozyme AC3 694405 4.6.1.1 adenylate cyclase heart isozyme AC5 694405 4.6.1.1 adenylate cyclase heart isozyme AC5 is localized to the same structures in adult mice 691717 4.6.1.1 adenylate cyclase heart isozyme AC6 694405 4.6.1.1 adenylate cyclase heart isozyme ACVI 693180 4.6.1.1 adenylate cyclase heart isozymes AC6, AC5, AC2 and AC3 694405 4.6.1.18 pancreatic ribonuclease heart weak expression 681841 4.6.1.19 ribonuclease T2 heart - -, 707879, 729845 4.6.1.2 guanylate cyclase heart - 690679, 691656, 691926, 692083, 692546, 692929, 693087, 693364, 693365, 693821, 694411, 708337 4.6.1.2 guanylate cyclase heart at both tissue and single myocyte levels, sGC protein expression is heterogeneous, being high in sinoatrial node, right atrium, right ventricle and left ventricular subepicardium, but markedly reduced to absent in left atrium and left ventricular subendocardium 691727 4.6.1.2 guanylate cyclase heart from lean and obese rats, enzyme localization at left ventricle and coronary arteriole 690358 4.6.1.2 guanylate cyclase heart isozymes GC-A 692548 4.6.1.6 cytidylate cyclase heart - -, 648785, 648786, 648790, 648792 4.98.1.1 protoporphyrin ferrochelatase heart - 34936 5.1.1.13 aspartate racemase heart - 706558 5.1.1.13 aspartate racemase heart high expression level 728034 5.1.1.18 serine racemase heart - 747888 5.1.1.18 serine racemase heart peripheral expression in cardiac myocyte 661409 5.1.99.4 alpha-methylacyl-CoA racemase heart weak 2449 5.3.1.21 corticosteroid side-chain-isomerase heart - 2655 5.3.1.6 ribose-5-phosphate isomerase heart two electrophorectic forms 2777 5.3.1.8 mannose-6-phosphate isomerase heart - 2826 5.3.1.9 glucose-6-phosphate isomerase heart - 2838, 2851 5.3.2.1 phenylpyruvate tautomerase heart - 2868 5.3.2.2 oxaloacetate tautomerase heart - 2877, 2878, 2879, 2880 5.3.3.12 L-dopachrome isomerase heart - 727347 5.3.3.21 DELTA3,5-DELTA2,4-dienoyl-CoA isomerase heart - 745267 5.3.3.3 vinylacetyl-CoA DELTA-isomerase heart - 2960 5.3.3.8 DELTA3-DELTA2-enoyl-CoA isomerase heart - 3002, 3009, 3014, 3019 5.3.4.1 protein disulfide-isomerase heart - 3049, 701629 5.3.4.1 protein disulfide-isomerase heart activities in adult tissues are only 10-40% of those found in newborn 3049 5.3.99.2 Prostaglandin-D synthase heart - 702057 5.3.99.3 prostaglandin-E synthase heart - 3134, 661310, 690714, 693551, 694942 5.3.99.3 prostaglandin-E synthase heart faint expression levels 661310 5.3.99.3 prostaglandin-E synthase heart mPEGS-2 667830 5.3.99.5 thromboxane-A synthase heart low activity 3183 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) heart - 3248, 703862 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) heart in early fetal life PGAM-BB is the only isozyme present in all tissues, in myogenesis these phenotypes undergo transition to MM-type via an MB-hybrid, all isozymes are present in mature heart tissue, enzyme activity increases with administration of 3,3'-triiodo-D-thyronine to the animal 3227 5.4.3.7 leucine 2,3-aminomutase heart - 3413, 3415, 3416 5.4.99.B22 multisite-specific tRNA pseudouridine synthase heart - 660654 5.5.1.4 inositol-3-phosphate synthase heart - 746709 5.5.1.4 inositol-3-phosphate synthase heart low expression 704640 5.6.1.1 microtubule-severing ATPase heart - 675537, 699690 5.6.1.1 microtubule-severing ATPase heart lower levels of spastin expression compared with neuronal tissues 699690 5.6.1.3 plus-end-directed kinesin ATPase heart - 210549 5.6.1.5 proteasome ATPase heart - 688447 5.6.1.6 channel-conductance-controlling ATPase heart - 675628 5.6.1.8 myosin ATPase heart - 751816 5.6.1.8 myosin ATPase heart conduction system and ventricular tissue 246994 5.6.1.8 myosin ATPase heart fibres from papillary muscle 699785 5.6.1.8 myosin ATPase heart left ventricular myocardium 655279 5.6.1.8 myosin ATPase heart left ventricular myofibril 656780 5.6.2.3 DNA 5'-3' helicase heart - 756521 6.1.1.11 serine-tRNA ligase heart high expression 660869 6.1.1.12 aspartate-tRNA ligase heart - 744436 6.1.1.2 tryptophan-tRNA ligase heart - 288 6.1.1.2 tryptophan-tRNA ligase heart about 0.02% of total soluble protein 306 6.1.1.20 phenylalanine-tRNA ligase heart - 649540 6.1.1.21 histidine-tRNA ligase heart - 745301 6.1.1.4 leucine-tRNA ligase heart - 693987 6.2.1.1 acetate-CoA ligase heart - 563, 567, 570, 572 6.2.1.1 acetate-CoA ligase heart AceCS2, high activity 652101 6.2.1.2 medium-chain acyl-CoA ligase heart - 675, 677 6.2.1.24 phytanate-CoA ligase heart - 702 6.2.1.3 long-chain-fatty-acid-CoA ligase heart - 649789, 671244, 671335, 672421, 733, 756 6.2.1.3 long-chain-fatty-acid-CoA ligase heart highly expressed in vascular endothelium 650399 6.2.1.4 succinate-CoA ligase (GDP-forming) heart - 652820, 662256, 727203, 744272, 785, 787, 789, 793 6.2.1.4 succinate-CoA ligase (GDP-forming) heart newborn and adult 794 6.2.1.5 succinate-CoA ligase (ADP-forming) heart - 702332, 744272, 799, 803 6.2.1.5 succinate-CoA ligase (ADP-forming) heart high level 693488 6.2.1.6 glutarate-CoA ligase heart - 828 6.3.1.2 glutamine synthetase heart - 37496, 691904 6.3.2.11 carnosine synthase heart - 744004, 988, 989, 995 6.3.2.18 gamma-glutamylhistamine synthase heart less than 10% enzyme activity in heart compared to ganglia 1102 6.3.2.2 glutamate-cysteine ligase heart - 649263, 672367, 692058 6.3.2.25 tubulin-tyrosine ligase heart - 663250 6.3.2.3 glutathione synthase heart - 691925, 705634 6.3.2.41 N-acetylaspartylglutamate synthase heart very low expression 727869 6.3.2.61 tubulin-glutamate ligase heart - 763305 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase heart low enzyme expression 652430 6.3.4.21 nicotinate phosphoribosyltransferase heart - -, 637754, 680797 6.3.4.21 nicotinate phosphoribosyltransferase heart 1.9 kb mRNA detected by Northern blot analysis, moderate expression -, 680797 6.3.4.21 nicotinate phosphoribosyltransferase heart significant endogenous activity 680797 6.3.4.4 adenylosuccinate synthase heart - 1537, 1543, 673163 6.3.4.4 adenylosuccinate synthase heart weak expression level of ADSS2 mRNA 673163 6.3.5.1 NAD+ synthase (glutamine-hydrolysing) heart - 1627 6.3.5.1 NAD+ synthase (glutamine-hydrolysing) heart the major sites of NADsyn1 gene expression are the small intestine, kidney, liver, and testis, whereas the skeletal muscle, spleen, lung, heart, and brain show a weak signal 652364 6.3.5.2 GMP synthase (glutamine-hydrolysing) heart - 1354, 1384 6.3.5.3 phosphoribosylformylglycinamidine synthase heart - 1664 6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing) heart - 1743 6.4.1.1 pyruvate carboxylase heart moderate activity 649667 6.4.1.2 acetyl-CoA carboxylase heart - 37599, 664193, 671950, 675028, 702619 6.4.1.2 acetyl-CoA carboxylase heart isozyme Acc2 664193, 664564 6.4.1.3 propionyl-CoA carboxylase heart - 1870 6.4.1.4 methylcrotonoyl-CoA carboxylase heart only trace levels 662759 7.1.1.1 proton-translocating NAD(P)+ transhydrogenase heart - 764052, 764194 7.1.1.2 NADH:ubiquinone reductase (H+-translocating) heart - 391082, 392676, 392684, 392691, 392692, 392699, 392703, 392717, 392718, 392721, 658174, 658265, 659106, 659108, 659109, 659946, 671827, 671882, 671993, 672013, 672126, 672176, 672291, 672348, 672597, 674694, 676868, 690886, 691037, 696270, 696312, 696510, 696745, 707505, 711290, 714281, 714993, 724252, 724383, 724564, 725002, 725003, 725491, 741606, 743263 7.1.1.8 quinol-cytochrome-c reductase heart - 395300, 396001, 439942, 439943, 439944, 439945, 439946, 439947, 439948, 439950, 439952, 439953, 439955, 439956, 439958, 439960, 439961, 439962, 439964, 439966, 439967, 439970, 439975, 439980, 439983, 439985, 439986, 439988, 439989, 439990, 439991, 439993, 440000, 440003, 440006, 440009, 440012, 440016, 440018, 440023, 440025, 440026, 440027, 440028, 440029, 440030, 440035, 657683, 658009, 658165, 658674, 659673, 672379, 696100, 724452, 725396, 742055 7.1.1.8 quinol-cytochrome-c reductase heart heart muscle 439944 7.1.1.8 quinol-cytochrome-c reductase heart highly expressed in heart, the expression increases in hearts of 4-, 10-, and 28-week-old spontaneously hypertensive rats. UCCR7.2 expression is reduced in the absence of ovarian hormones, but is not directly regulated by estrogen in the heart. UCCR7.2 is a steroid hormone-responsive gene in the heart, with expression increased in cardiac hypertrophy and in response to hypertension 685905 7.1.1.8 quinol-cytochrome-c reductase heart Keilin-Hartree muscle preparation 439957 7.1.1.9 cytochrome-c oxidase heart - 395999, 396016, 396019, 396028, 396033, 396035, 396037, 396039, 396040, 396041, 396043, 396049, 396052, 396055, 396058, 396063, 396064, 396065, 396067, 396077, 396080, 396083, 396084, 396092, 396104, 396117, 396118, 396121, 396126, 657655, 658173, 658620, 659582, 673702, 676865, 686054, 690359, 691023, 691038, 691404, 691758, 693006, 693787, 694175, 695076, 711289, 741541, 742002, 742031, 743264, 752934, 755271 7.1.1.9 cytochrome-c oxidase heart downregulation of enzyme activity in the neonatal period by factor 3 672953 7.1.1.9 cytochrome-c oxidase heart thyroid hormone T3 has no effect on COX Vb expression 657516 7.1.2.2 H+-transporting two-sector ATPase heart - 210232, 210233, 210237, 210239, 210244, 210245, 210249, 210264, 671243, 672313, 673318, 696051, 698676, 711328, 712401, 720931 7.1.2.2 H+-transporting two-sector ATPase heart healthy and ischemic 698308 7.2.2.10 P-type Ca2+ transporter heart - 210479, 210482, 210485, 670757, 695858, 697167, 718751, 720121, 733277, 733416, 734372, 750281, 751396 7.2.2.10 P-type Ca2+ transporter heart methods to employ tissue homogenates to study sarcoplasmatic reticulum Ca2+ transport function in individual mouse hearts 210494 7.2.2.10 P-type Ca2+ transporter heart PMCA2 is expressed at a lower level in the heart 695858 7.2.2.10 P-type Ca2+ transporter heart predominant expression of splice variant PMCA4e 734295 7.2.2.10 P-type Ca2+ transporter heart the PMCA4 pump is expressed in heart, PMCA2 is expressed at a lower level in the heart 695858 7.2.2.13 Na+/K+-exchanging ATPase heart - 246962, 246969 7.2.2.13 Na+/K+-exchanging ATPase heart adult 656021 7.2.2.13 Na+/K+-exchanging ATPase heart fetal 656021 7.2.2.13 Na+/K+-exchanging ATPase heart muscle 696017 7.2.2.13 Na+/K+-exchanging ATPase heart Na+K+-ATPase activity is positively regulated via an N-terminal phosphorylation site that is necessary for correct heart morphogenesis to occur, and maintenance of Zonula occludens-1 junction belts requires ion pump activity 687903 7.2.2.14 P-type Mg2+ transporter heart - 289134, 699744, 700652 7.2.2.19 H+/K+-exchanging ATPase heart - 654149 7.2.2.9 P-type Cu2+ transporter heart - 246908, 699709 7.3.2.2 ABC-type phosphonate transporter heart - 289158 7.6.2.2 ABC-type xenobiotic transporter heart - 697587 7.6.2.3 ABC-type glutathione-S-conjugate transporter heart - 748624