1.1.1.300 NADP-retinol dehydrogenase glioma cell high RDH10 expression level, 13.89%, 43.59%, 70.59%, and 90.24% expression of RDH10 in glioma of grade I, II, III, and IV (WHO grading), respectively 762073 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) glioma cell - 761332 1.1.1.41 isocitrate dehydrogenase (NAD+) glioma cell - 712180 1.1.1.42 isocitrate dehydrogenase (NADP+) glioma cell - 712180, 712574, 712614, 713113, 739984 1.1.1.42 isocitrate dehydrogenase (NADP+) glioma cell IDH1, diffuse gliomas graded II-IV 713508 1.1.1.42 isocitrate dehydrogenase (NADP+) glioma cell of grade II-III gliomas 713100 1.1.1.42 isocitrate dehydrogenase (NADP+) glioma cell progressive gliomas 711107 1.13.11.31 arachidonate 12-lipoxygenase glioma cell - 688759 1.13.11.34 arachidonate 5-lipoxygenase glioma cell - 688512 1.13.11.34 arachidonate 5-lipoxygenase glioma cell high enzyme expression level 686278 1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase glioma cell - 756531 1.14.14.14 aromatase glioma cell - 726047 1.14.14.18 heme oxygenase (biliverdin-producing) glioma cell - 690140 1.14.15.18 calcidiol 1-monooxygenase glioma cell - 659811 1.14.16.4 tryptophan 5-monooxygenase glioma cell - 687604 1.14.19.17 sphingolipid 4-desaturase glioma cell - 744686 1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+) glioma cell astrocytomas and oligodendrogliomas 763330 1.2.1.3 aldehyde dehydrogenase (NAD+) glioma cell - 741427 1.4.1.3 glutamate dehydrogenase [NAD(P)+] glioma cell gene expression profiling reveals that GLUD2 is selectively and consistently upregulated in glioma cells harboring IDH mutations 762783 1.4.3.4 monoamine oxidase glioma cell activity selectively increases in MAO-B activity in human gliomas when compared with meningiomas or non-tumoural tissue 689175 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase glioma cell - 673219, 701644, 705897 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase glioma cell biopsies 688740 2.1.2.1 glycine hydroxymethyltransferase glioma cell expression of SHMT2 in ischemic tumor zones 736882 2.1.2.2 phosphoribosylglycinamide formyltransferase 1 glioma cell the enzyme is frequently overexpressed in glioma, enzyme immunohistochemic analysis in 70 cases of human gliomas and normal brain tissues, overview 736945 2.3.1.299 sphingoid base N-stearoyltransferase glioma cell - 757888 2.3.1.48 histone acetyltransferase glioma cell - 756850 2.3.1.57 diamine N-acetyltransferase glioma cell - 757876 2.3.1.B41 protein-long-chain fatty-acyl-lysine deacylase (NAD+) glioma cell SIRT6 is down-regulated in human glioma tissues 729145 2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase glioma cell cell proliferation and migration analysis, overview 759196 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase glioma cell of brain with subarachnoid spread. Distinct POMT1 alterations may contribute to a functional impairment of protein-omannosyltransferase activity. In individual tumor specimens selective alterations of the POMT1 gene may be compatible with clonal evolution of distinct sublocations 689201 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase glioma cell - 736507 2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase glioma cell CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival 759875 2.4.1.212 hyaluronan synthase glioma cell cell line 395258 2.4.1.224 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase glioma cell - 759360 2.4.1.225 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase glioma cell - 759360 2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase glioma cell CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival 759875 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase glioma cell - 685932, 718736 2.4.1.47 N-acylsphingosine galactosyltransferase glioma cell human fetal glioma cell line 489221 2.4.1.47 N-acylsphingosine galactosyltransferase glioma cell N-370 FG cells 489221, 489224 2.4.2.12 nicotinamide phosphoribosyltransferase glioma cell - 735872 2.4.2.3 uridine phosphorylase glioma cell UPP1 is significantly upregulated in glioma, especially in glioblastoma 758991 2.5.1.26 alkylglycerone-phosphate synthase glioma cell - 737578, 739210 2.6.1.42 branched-chain-amino-acid transaminase glioma cell - 758657 2.7.1.1 hexokinase glioma cell hexokinase I, predominant in normal brain 640259 2.7.1.1 hexokinase glioma cell hexokinase II, increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line 640259 2.7.1.105 6-phosphofructo-2-kinase glioma cell - 739621, 761915 2.7.1.127 inositol-trisphosphate 3-kinase glioma cell human glioma cell line HTB-138, InsP3 3-kinase B mRNA 640751 2.7.1.137 phosphatidylinositol 3-kinase glioma cell - 709276 2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase glioma cell - 709907 2.7.1.3 ketohexokinase glioma cell expressed at significantly higher level in glioma tissues than in non-tumor brain 758732 2.7.1.94 acylglycerol kinase glioma cell - 761230 2.7.10.2 non-specific protein-tyrosine kinase glioma cell - 721489 2.7.11.11 cAMP-dependent protein kinase glioma cell - 662380 2.7.11.13 protein kinase C glioma cell - 676323 2.7.11.20 elongation factor 2 kinase glioma cell - 760810 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase glioma cell - 760351 2.7.12.2 mitogen-activated protein kinase kinase glioma cell MKK3 i s upregulated and activated in invasive glioma cells in vitro, overexpression and phosphorylation of MKK3 are linked to glioma invasion, MKK3 is overexpressed in invasive glioma cells in situ and correlates with active p38 681871 2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase glioma cell - 645316 2.7.8.27 sphingomyelin synthase glioma cell - 737747 2.8.2.17 chondroitin 6-sulfotransferase glioma cell - 761061 2.8.2.23 [heparan sulfate]-glucosamine 3-sulfotransferase 1 glioma cell - 759360 2.8.2.29 [heparan sulfate]-glucosamine 3-sulfotransferase 2 glioma cell - 759360 2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase glioma cell - 759360 3.1.1.89 protein phosphatase methylesterase-1 glioma cell in human glioma cell, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance 749865 3.1.3.16 protein-serine/threonine phosphatase glioma cell - 692085, 750280 3.1.3.5 5'-nucleotidase glioma cell - 694138 3.1.3.7 3'(2'),5'-bisphosphate nucleotidase glioma cell in glioma tissues, phosphocholine(36:1) is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated, quantitative real-time polymerase chain reaction (qRT-PCR) expression analysis. Gene expression of enzymes associated with pAp metabolism 752237 3.1.3.77 acireductone synthase glioma cell - 751767 3.1.4.11 phosphoinositide phospholipase C glioma cell C6Bu-1 rat glioma cell, isoenzyme PI-PLC-beta1 668867 3.1.4.12 sphingomyelin phosphodiesterase glioma cell C6-glioma cells 652974 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase glioma cell - 135401 3.1.4.4 phospholipase D glioma cell - 708012 3.1.6.13 iduronate-2-sulfatase glioma cell - 650371 3.2.1.143 poly(ADP-ribose) glycohydrolase glioma cell primary culture, highest ratio of nuclear to cytoplasmic enzyme activity 664476 3.2.1.166 heparanase glioma cell - 693320, 759360 3.2.1.45 glucosylceramidase glioma cell - 751699 3.3.2.6 leukotriene-A4 hydrolase glioma cell - 752495 3.4.14.5 dipeptidyl-peptidase IV glioma cell - 703784 3.4.19.12 ubiquitinyl hydrolase 1 glioma cell - 710451 3.4.21.109 matriptase glioma cell - 717799 3.4.21.26 prolyl oligopeptidase glioma cell - 669933, 683344 3.4.21.73 u-Plasminogen activator glioma cell - 710121 3.4.21.75 Furin glioma cell - 708753 3.4.21.B28 fibroblast activation protein alpha subunit glioma cell - 707629 3.4.21.B28 fibroblast activation protein alpha subunit glioma cell increased enzyme expression in a subgroup of high-grade gliomas. The enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth 755628 3.4.22.1 cathepsin B glioma cell astrocytic 707558 3.4.22.15 cathepsin L glioma cell - 712921 3.4.22.60 caspase-7 glioma cell - 700938 3.4.22.61 caspase-8 glioma cell - 664508 3.4.22.61 caspase-8 glioma cell stem-cell-like and non-stem-cell-like glioma cell 695401 3.4.22.61 caspase-8 glioma cell stem-cell-like glioma cell, low enzyme expression levels due to hypermethylation of the CASP8 promoter, also expressed in non-stem-like glioma cell 695401 3.4.22.62 caspase-9 glioma cell - 665736 3.4.22.B70 SENP1 peptidase glioma cell - 753729 3.4.24.17 stromelysin 1 glioma cell - 708089 3.4.24.23 matrilysin glioma cell highly variable MMP-7 expression in the glioma population 683864 3.4.24.24 gelatinase A glioma cell high expression level of MMP-2 increasing during growth 683427 3.4.24.35 gelatinase B glioma cell high expression level of MMP-9 increasing during growth 683427 3.4.24.82 ADAMTS-4 endopeptidase glioma cell - 638956 3.4.24.B4 matrix metalloproteinase-13 glioma cell - 711163 3.4.24.B7 matrix metalloproteinase-26 glioma cell - 713160, 754946 3.6.1.9 nucleotide diphosphatase glioma cell - 246803 3.6.1.9 nucleotide diphosphatase glioma cell homologue to plasma cell membrane glycoprotein PC-1 246804 4.1.1.17 ornithine decarboxylase glioma cell - 680217, 682982, 697101, 697861 4.3.2.9 gamma-glutamylcyclotransferase glioma cell - 735619 4.4.1.5 lactoylglutathione lyase glioma cell - 709654 4.6.1.1 adenylate cyclase glioma cell - 694258 5.1.1.18 serine racemase glioma cell - 705283 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase glioma cell - 759360 5.3.99.3 prostaglandin-E synthase glioma cell - 681868 5.3.99.5 thromboxane-A synthase glioma cell - 705275 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) glioma cell - 748795 6.3.1.2 glutamine synthetase glioma cell - 671608, 745832 6.3.5.4 asparagine synthase (glutamine-hydrolysing) glioma cell - 745756