1.1.1.102 3-dehydrosphinganine reductase gill - 721947 1.1.1.146 11beta-hydroxysteroid dehydrogenase gill prominent expression in testis, anterior kidney, liver and gills 725812 1.1.1.28 D-lactate dehydrogenase gill - 286483 1.1.1.43 phosphogluconate 2-dehydrogenase gill - 710781 1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+) gill enzyme is stimulated in presence of 3 mg and 5 mg of Cd on the first day of experiment in gill, liver and kidney tissues. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished after seven days. The G6PD enzyme activity levels are stimulated by approximately 60% in gills 710781 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase gill isozyme 17beta-HSD8 675476 1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase gill - 654932, 655669, 688455, 698084 1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase gill high expression 763470 1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase gill high expression of subunit A, moderate expression of subunit B 762606 1.11.1.24 thioredoxin-dependent peroxiredoxin gill - 686887, 698018, 698025 1.11.1.24 thioredoxin-dependent peroxiredoxin gill the enzyme is expressed in all adult amphioxus tissues except testis, with the highest level found in the gill 758146 1.11.1.24 thioredoxin-dependent peroxiredoxin gill upregulation after anti-white spot syndrome virus challenge 725050 1.11.1.6 catalase gill - 696576, 700588, 724791, 725156, 725932 1.11.1.6 catalase gill constitutive expression for the first 3 h post injection of H2O2 686832 1.11.1.6 catalase gill highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart 744948 1.11.1.9 glutathione peroxidase gill - 724798, 725049, 725051 1.11.1.9 glutathione peroxidase gill highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart 744948 1.11.1.9 glutathione peroxidase gill low expression 725048 1.11.2.2 myeloperoxidase gill - 764550 1.13.11.31 arachidonate 12-lipoxygenase gill - 395412, 395413 1.13.11.33 arachidonate 15-lipoxygenase gill - 639242 1.13.11.52 indoleamine 2,3-dioxygenase gill - 671570 1.14.11.29 hypoxia-inducible factor-proline dioxygenase gill - 741826, 743203 1.14.11.4 procollagen-lysine 5-dioxygenase gill - 724792 1.14.13.39 nitric-oxide synthase (NADPH) gill - 744948 1.14.13.8 flavin-containing monooxygenase gill - 703402 1.14.14.1 unspecific monooxygenase gill - 673315 1.14.14.19 steroid 17alpha-monooxygenase gill - 703775, 705401 1.14.14.32 17alpha-hydroxyprogesterone deacetylase gill weakly present 703775 1.14.16.4 tryptophan 5-monooxygenase gill low levels of TPH-1 705929 1.14.16.4 tryptophan 5-monooxygenase gill low levels of TPH-2 705929 1.14.19.3 acyl-CoA 6-desaturase gill - 659836 1.14.19.3 acyl-CoA 6-desaturase gill weak expression 697459 1.14.19.30 acyl-lipid (8-3)-desaturase gill - 746201 1.14.19.47 acyl-lipid (9-3)-desaturase gill DELTA6fad is constitutively expressed 744748 1.14.19.47 acyl-lipid (9-3)-desaturase gill highest DELTA6fad mRNA expression is detected in liver followed by brain, with lower expression in other tissues including intestine, eye, muscle, adipose, heart kidney and gill, and lowest expression in stomach and spleen 746261 1.15.1.1 superoxide dismutase gill - 657632, 703780, 727563, 745093, 746564 1.15.1.1 superoxide dismutase gill cytoplasmic manganese SOD 745093 1.15.1.1 superoxide dismutase gill low expression level 744746 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) gill low expression level 744945 1.2.1.104 pyruvate dehydrogenase system gill - 695494 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) gill moderate expression 698019 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) gill weak expression 698019 1.2.1.8 betaine-aldehyde dehydrogenase gill - 740335 1.21.99.3 thyroxine 5-deiodinase gill gene expression 644802 1.21.99.4 thyroxine 5'-deiodinase gill - 733894 1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase gill - 740358 1.4.3.1 D-aspartate oxidase gill - 657350 1.4.3.2 L-amino-acid oxidase gill - 711987, 724814, 742345 1.4.3.2 L-amino-acid oxidase gill dominantly expressed 692408 1.4.3.2 L-amino-acid oxidase gill pronounced expression 763047 1.4.3.3 D-amino-acid oxidase gill - 657350 1.4.3.3 D-amino-acid oxidase gill low activity 657350 1.5.1.10 saccharopine dehydrogenase (NADP+, L-glutamate-forming) gill - -, 765188 1.5.1.11 D-octopine dehydrogenase gill - 13302, 741868 1.5.1.11 D-octopine dehydrogenase gill anodally migrating isoform 13293 1.5.1.17 alanopine dehydrogenase gill - 13365, 13371, 13372, 741868 1.5.1.22 Strombine dehydrogenase gill - 741868 1.5.1.23 Tauropine dehydrogenase gill - 741868 1.5.1.26 beta-alanopine dehydrogenase gill - 644725 1.5.1.26 beta-alanopine dehydrogenase gill very low activity 725659 1.5.3.13 N1-acetylpolyamine oxidase gill - 742614 1.5.3.17 non-specific polyamine oxidase gill - 742614 1.6.3.1 NAD(P)H oxidase (H2O2-forming) gill expressed highly in hemocytes, followed by comparable expression in hepatopancreas and moderate expression in brain, eyestalk and intestine, but with relatively low expressions in gill, heart and muscle 744948 1.8.1.7 glutathione-disulfide reductase gill - 699961 1.8.1.7 glutathione-disulfide reductase gill highest mRNA expression of mitochondrial isoform of Liza haematocheila glutathione reductase is observed in the gill tissue under normal physiological conditions 764549 1.8.5.8 eukaryotic sulfide quinone oxidoreductase gill - 764525 2.1.1.137 arsenite methyltransferase gill - 721074 2.1.1.2 guanidinoacetate N-methyltransferase gill - 686291 2.1.1.321 type III protein arginine methyltransferase gill - 757338 2.1.1.325 juvenile hormone-III synthase gill - 738943 2.1.1.6 catechol O-methyltransferase gill - 733893 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase gill - 485494 2.1.4.1 glycine amidinotransferase gill - 686291 2.3.1.21 carnitine O-palmitoyltransferase gill - 735980 2.3.1.37 5-aminolevulinate synthase gill - 756863 2.3.1.57 diamine N-acetyltransferase gill - 737100 2.3.1.87 aralkylamine N-acetyltransferase gill - 673823 2.3.2.13 protein-glutamine gamma-glutamyltransferase gill - 487873, 735731 2.4.1.1 glycogen phosphorylase gill - 706837 2.4.1.11 glycogen(starch) synthase gill - 756508 2.4.1.66 procollagen glucosyltransferase gill - 724792 2.5.1.18 glutathione transferase gill - 674395, 686226, 703306, 738998, 759081, 759685 2.5.1.18 glutathione transferase gill HdGSTO1 703309 2.5.1.18 glutathione transferase gill high expression of isoforms Gsto2, Gstp, Gstm, Gstr1, Mgst3a, and Mgst3b 737546 2.5.1.18 glutathione transferase gill highest expression of isoform GSTrho 759081 2.5.1.18 glutathione transferase gill pi and/or alpha class GSTs are the dominant GST classes in gills 703304 2.5.1.2 thiamine pyridinylase gill - 636845 2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] gill - 703292 2.6.1.1 aspartate transaminase gill - 636732, 739622 2.6.1.2 alanine transaminase gill - 636732 2.7.1.1 hexokinase gill moderate activity 759359 2.7.1.30 glycerol kinase gill - 721260 2.7.1.52 fucokinase gill - 703298 2.7.11.1 non-specific serine/threonine protein kinase gill - 742344 2.7.11.24 mitogen-activated protein kinase gill - 681966, 761111 2.7.11.25 mitogen-activated protein kinase kinase kinase gill highest expression 761109 2.7.11.30 receptor protein serine/threonine kinase gill - 761110 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase gill - 693405, 760910 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase gill high expression 760911 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase gill highest expression of subunit AMPKbeta2 760910 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase gill highest expression of subunit AMPKgamma1 760910 2.7.3.3 arginine kinase gill - 722305 2.7.3.3 arginine kinase gill low expression of PyAK2, high expression of PyAK3 760431 2.7.3.3 arginine kinase gill very low mRNA expression 703776 2.7.4.6 nucleoside-diphosphate kinase gill - 691029 2.7.4.6 nucleoside-diphosphate kinase gill low activity 762220 2.8.2.1 aryl sulfotransferase gill low SULT1,3 expression level 671776 3.1.1.4 phospholipase A2 gill highest activity 650888, 653099 3.1.1.7 acetylcholinesterase gill - 653108 3.1.1.7 acetylcholinesterase gill highest activity in gill tissue 729567 3.1.1.8 cholinesterase gill - 653108, 682854, 714388 3.1.2.6 hydroxyacylglutathione hydrolase gill activity is unchanged after a two-week exposure to a sublethal concentration (1.6 mM) of Cu2+ compared to untreated control specimens in marine water 678112 3.1.22.1 deoxyribonuclease II gill higher enzyme activity in the gills observed in the autumn/winter period can be associated with feeding and cellular adaptation to low seawater temperatures 751444 3.1.3.1 alkaline phosphatase gill - 650882 3.1.3.1 alkaline phosphatase gill high pH-values increase enzyme activity 680124 3.1.3.108 nocturnin gill low expression 755768 3.1.3.11 fructose-bisphosphatase gill very low enzyme expression level 750565 3.1.3.12 trehalose-phosphatase gill gene expression in 695123 3.1.3.2 acid phosphatase gill - 650882, 681740 3.1.3.25 inositol-phosphate phosphatase gill - 701707, 714937 3.1.3.41 4-nitrophenylphosphatase gill - 664640 3.1.3.5 5'-nucleotidase gill - 650886 3.1.4.11 phosphoinositide phospholipase C gill - -, 691897 3.1.4.3 phospholipase C gill - -, 650878 3.1.4.3 phospholipase C gill isoform PLCG2 750568 3.1.4.4 phospholipase D gill - 692410 3.13.2.1 adenosylhomocysteinase gill - 696860, 753615 3.2.1.17 lysozyme gill - 729620, 729763, 750570, 750571 3.2.1.17 lysozyme gill constitutively expressed 677863 3.2.1.17 lysozyme gill contains exclusively g-type lysozyme 729618 3.2.1.17 lysozyme gill high mRNA expression 700107 3.2.1.17 lysozyme gill highest expression 751489 3.4.11.1 leucyl aminopeptidase gill - 698424 3.4.11.2 membrane alanyl aminopeptidase gill high enzyme activity 665836 3.4.11.3 cystinyl aminopeptidase gill - 753723 3.4.11.6 aminopeptidase B gill - 665836 3.4.11.7 glutamyl aminopeptidase gill - 665836 3.4.15.1 peptidyl-dipeptidase A gill - 731940 3.4.18.1 cathepsin X gill - 691910 3.4.19.1 acylaminoacyl-peptidase gill - 731801 3.4.19.12 ubiquitinyl hydrolase 1 gill - 709879 3.4.21.108 HtrA2 peptidase gill - 732873 3.4.21.32 brachyurin gill - 731830, 731881 3.4.21.35 tissue kallikrein gill - 683016 3.4.21.41 complement subcomponent C1r gill - 753598 3.4.21.41 complement subcomponent C1r gill high expression 753377 3.4.21.42 complement subcomponent C1s gill high expression 753377 3.4.21.45 complement factor I gill - 753374 3.4.21.45 complement factor I gill expression shown by RT-PCR 708534 3.4.21.46 complement factor D gill high mRNA expression determined by real-time RT-PCR 708533 3.4.21.46 complement factor D gill moderate expression 753602, 753616 3.4.21.78 granzyme A gill predominant expression 717616 3.4.22.1 cathepsin B gill - 717519, 733697, 733698, 733892, 753327, 753603 3.4.22.1 cathepsin B gill highest expression and high activity in gills 717518 3.4.22.1 cathepsin B gill moderate expression 718097 3.4.22.15 cathepsin L gill - 717615, 731834, 753596, 753600 3.4.22.16 cathepsin H gill high expression level in intestine and gill, but barely in other tissues 698021 3.4.22.27 cathepsin S gill - 753606 3.4.22.36 caspase-1 gill high activity. Bacterial infection leads to a decrease in the mRNA levels of caspase-1 681973 3.4.22.38 cathepsin K gill - 708216, 708535, 753618 3.4.22.41 cathepsin F gill - 708220, 717638 3.4.22.41 cathepsin F gill expressed at a relatively low level 753610 3.4.22.42 cathepsin O gill - 717619 3.4.22.56 caspase-3 gill - 717617, 753607 3.4.22.59 caspase-6 gill - 752585 3.4.22.60 caspase-7 gill and blood, second highest expression level 752586 3.4.22.61 caspase-8 gill high expression 731686 3.4.22.62 caspase-9 gill - 717527 3.4.22.63 caspase-10 gill high exxpression level 731832 3.4.22.63 caspase-10 gill strong expression 679931 3.4.22.B29 calpain 9 gill - 665012 3.4.22.B31 calpain 11 gill weak expression 708582 3.4.22.B37 calpain B gill - 665858 3.4.22.B49 cathepsin L1 gill - 708536 3.4.22.B49 cathepsin L1 gill moderate enzyme content 753379 3.4.23.3 gastricsin gill pepsinogen C transcript is first detected at 41 days post hatching and continuously expressed through to adult fish 686228 3.4.23.5 cathepsin D gill - 698022, 712987, 731700, 731831 3.4.23.5 cathepsin D gill weak expression 753378 3.4.24.21 astacin gill - 669208 3.4.24.24 gelatinase A gill higher expression 753613 3.4.24.71 endothelin-converting enzyme 1 gill - 683713 3.4.24.B4 matrix metalloproteinase-13 gill - 711825 3.5.2.17 hydroxyisourate hydrolase gill - 733937 3.5.3.1 arginase gill tissues grouped based on their expression as follows, from lowest to highest: 1. intestine; 2. adipose tissue, spleen, blood, head kidney, scales and tail fin; 3. adipose fin, brain, heart, gonad, muscle and thymus; 4. skin; 5. gills and liver; 6. posterior kidney 753605 3.5.3.1 arginase gill tissues grouped based on their expression as follows, from lowest to highest: 1. liver; 2. intestine and tail fin; 3. adipose tissue, spleen, gills and scales; 4. adipose fin, skin, blood, posterior kidney, gonad, head kidney and thymus; 5. heart; 6. brain and muscle 753605 3.5.3.1 arginase gill tissues grouped based on their expression as follows, from lowest to highest: 1. liver; 2. tail fin; 3. adipose tissue, intestine, posterior kidney, head kidney, heart and skin; 4. blood, gonad, scales, gills, spleen, brain, thymus; 5. adipose fin and muscle 753605 3.5.3.1 arginase gill tissues grouped based on their expression as follows, from lowest to highest: 1. tail fin, intestine and scales; 2. adipose tissue, spleen and head kidney; 3. adipose fin and posterior kidney; 4. blood, muscle and thymus; 5. gills; 6. brain, skin, heart, gonad and liver 753605 3.5.3.4 allantoicase gill - 664657 3.5.4.5 cytidine deaminase gill - 711824 3.5.4.6 AMP deaminase gill - 209691, 686221 3.6.5.2 small monomeric GTPase gill - 756748 4.1.1.28 aromatic-L-amino-acid decarboxylase gill - 716702 4.1.1.28 aromatic-L-amino-acid decarboxylase gill no expression of ddc gene 694106 4.1.1.29 sulfinoalanine decarboxylase gill - 746717, 746903, 749353 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP) gill - 681148, 747633 4.1.99.13 (6-4)DNA photolyase gill - 747608 4.1.99.3 deoxyribodipyrimidine photo-lyase gill - 747608 4.2.1.1 carbonic anhydrase gill - 33594, 652647, 665857, 678737, 682703, 697451, 748131, 748840 4.2.1.1 carbonic anhydrase gill carbonic anhydrase activity is low and uniform across gills in shrimp acclimated to osmolarity of 30 ppt, but carbonic anhydrase activity increases in all gils after exposure to both low and high salinities. Anterior gills have the largest increases in carbonic anhydrase activity, and levels of increase are approximately the same for low and high salinity exposure. Induction of branchial carbonic anhydrase appears to be functionally important in both hyper- and hypo-osmotic regulations of hemolymph osmotic concentrations 679314 4.2.1.1 carbonic anhydrase gill expression of the cytoplasmic isoform in the posterior gill (CasCAc) undergoes a significantly greater degree of up-regulation after exposure to low salinity (15·p.p.t.) as compared to high salinity. CasCAc has the largest scope of induction (100fold) reported for any transportrelated protein in the gill 681115 4.2.1.1 carbonic anhydrase gill high expression 681114 4.2.1.1 carbonic anhydrase gill intermediate activity 665835 4.2.1.1 carbonic anhydrase gill pavement cells forming the gill epithelial surface layer, mucous cells, pillar cells bordering the vascular channels of the secondary lamellae, chloride cells, mitochondria-rich cells located in the primary epithelium, interlamellar regions, bases of the secondary lamellae 33589 4.2.1.1 carbonic anhydrase gill the membrane associated isoform CasCAg is present in much higher levels of mRNA expression in both anterior and posterior gills in crabs acclimated to high salinity (35·p.p.t.) compared to crabs acclimated to low salinity 681115 4.2.1.24 porphobilinogen synthase gill - 664768 4.3.2.1 argininosuccinate lyase gill - 676120 4.3.2.2 adenylosuccinate lyase gill lowest expression 716175 4.4.1.1 cystathionine gamma-lyase gill - 690376 4.6.1.1 adenylate cyclase gill - 663747, 665877 5.5.1.4 inositol-3-phosphate synthase gill - 746709 5.6.1.6 channel-conductance-controlling ATPase gill apical pits of seawater chloride cells 671770 6.3.2.2 glutamate-cysteine ligase gill - 691912 6.3.4.5 argininosuccinate synthase gill Northern analyses of ass during fruiting body formation and post-harvest development reveals that expression is significantly up-regulated from developmental stage 3 on for all the tissues studied (gills, stip and cap). The expression reaches a maximum at the later stages of fruiting body growth, stages 6 and 7 676120 7.2.2.10 P-type Ca2+ transporter gill - 684657, 750694 7.2.2.10 P-type Ca2+ transporter gill expression and activity during molting cycle, overview 669657 7.2.2.13 Na+/K+-exchanging ATPase gill - 246955, 684363, 686200, 686204, 697452, 697455, 698083, 720113, 733313, 733681, 734461, 734462, 734580, 750006, 750351, 750354, 751228, 751290, 751423, 751559 7.2.2.13 Na+/K+-exchanging ATPase gill acclimation to dilute seawater induces increased expression of Na+K+-ATPase and enzyme activity, with the increase being less in juveniles than in larger crabs. Juveniles maintain osmotic and ionic homeostasis by the expression and utilization of extremely high levels of gill Na+K+ATPase, in posterior, as well in anterior, gills 688107 7.2.2.13 Na+/K+-exchanging ATPase gill following acclimation in dilute seawater, specific activity of Na+K+-ATPase is progressively increased up to 3.9fold. Increased enzyme activity may be modulated by the changed proportion of fatty acids in the purified membranes of posterior gills. Long-term acclimation to dilute seawater results in increase in metallothionein content in posterior gill 686206 7.2.2.13 Na+/K+-exchanging ATPase gill in the apical region of the epithelial pillar cells, and throughout the pillar cell bodies 751290 7.2.2.13 Na+/K+-exchanging ATPase gill Na+K+-ATPase constitutes 80% of total ATPase activity 686205 7.2.2.13 Na+/K+-exchanging ATPase gill neither osmotic pressure, Na+K+-ATPase activity, nor free amino acids are affected by diets rich/low in highly unsaturated fatty acids. Higher water content in gills of shrimp exposed to low salinty is counteracted by increased content in highly unsaturated fatty acids 686203 7.2.2.14 P-type Mg2+ transporter gill - 701311 7.2.2.15 P-type Ag+ transporter gill - 210452 7.2.2.19 H+/K+-exchanging ATPase gill enzyme expression 2.39fold greater in freshwater-acclimated stingrays than seawater stringrays 671211