1.5.1.6 formyltetrahydrofolate dehydrogenase PPC-1 cell - 3.4.23.34 cathepsin E PPC-1 cell - 3.5.1.23 ceramidase PPC-1 cell - 3.5.1.23 ceramidase PPC-1 cell acid ceramidase is closely associated with malignant progression in human prostate cancer tissues. Acid ceramidase upregulation generates tumor cells that are resistant to normal homeostatic control mechanisms, have an increased number of metastatic characteristics and exhibit resistance to chemotherapy