1.11.1.9	glutathione peroxidase	HPAEC cell	human primary pulmonary artery endothelial cells	
3.2.1.18	exo-alpha-sialidase	HPAEC cell	-	
3.4.21.5	thrombin	HPAEC cell	both thrombin and thrombin receptor agonist peptide enhance the permeability barrier of cells, both exhibit a potent barrier protective effect when cells are treated with inactive mutant S195A of protein C prior to stimulation. Thrombin exhibits a potent cytoprotective activity in the lipopolysaccharide-induced permeability and tumor necrosis factor alpha-induced apoptosis and adhesion assays in the protein C mutant S195A treated cells. Treatment with the cholesterol depleting molecule methyl-beta-cyclodextrin eliminates the protective effect	
4.1.2.27	sphinganine-1-phosphate aldolase	HPAEC cell	-