2.3.1.B43 protein-lysine desuccinylase (NAD+) 16-HBE14o cell 2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase 16-HBE14o cell 3.4.21.B25 PACE4 proprotein convertase 16-HBE14o cell