3.4.21.7 A-549 cell plasmin is generated by the plasmin/u-PA system on surfaces of A-549 alveolar lining cells 688780 3.4.21.7 artery vessel wall 717165 3.4.21.7 astrocyte plasmin evokes an increase in both phosphoinositide hydrolysis and Fura-2/AM fluorescence in cultured cortical astrocytes. Plasmin activiates extracellular signal-regulated kinase and induces a rise in intracellular Ca2+ concentration and phopho-ERK1/2 levels 698776 3.4.21.7 blood - 652141, 732405 3.4.21.7 blood plasma - 669210, 731263, 732904 3.4.21.7 blood plasma plasma obtained from coronary artery disease patients contains 1.7fold more plasmin compared to controls 670064 3.4.21.7 blood serum - 697405 3.4.21.7 bone marrow cell - 717866 3.4.21.7 commercial preparation - 695548, 698862, 698888, 699204, 699867, 701162, 717259, 717386, 717469, 717845, 717866 3.4.21.7 commercial preparation purified enzyme 718272 3.4.21.7 endometrial stromal cell - 708672 3.4.21.7 eye - 687206, 701187 3.4.21.7 fibroblast - 709033 3.4.21.7 flexor tendon - 732222 3.4.21.7 heart - 732904 3.4.21.7 hepatic stellate cell - 718070 3.4.21.7 hippocampus plasmin has no effect on ERK1/2 signaling or Ca2+ concentraion in primary cultured hippocampal neurons or hippocampal slices 698776 3.4.21.7 HSC-180 cell originally isolated from a cirrhotic liver 718070 3.4.21.7 HT-29 cell plasmin induces scattering of HT-29-M6 cells in the presence of 12-myristate 13-acetate 668502 3.4.21.7 HUVEC cell plasmin induces a concentration-dependent transient elevation in the cytosolic Ca2+ concentrations 684784 3.4.21.7 L-5178-Y cell leukaemic cell line. In L5178Y cells with knock-out of the gene for annexin A2, the mRNA level of plasminogen is not substantially changed, but the protein level of plasmin is significantly lowered. mRNA and protein levels of S100A10 and fascin are lower in annexin A2 knock-out cells than in wild-type L5178Y cells 697079 3.4.21.7 macrophage plasmin triggers expression and release of proinflammatory cytokines such as TNF-alpha and IL-6 in human monocyte-derived macrophages with a somewhat lower potency than the standard stimulus lipopolysaccharide. Plasmin-induced activation of JAK1, p38, ERK1/2, and NF-kappaB is indispensable for the cytokine expression 684778 3.4.21.7 mesangial cell - 688737 3.4.21.7 milk - 668957, 669643, 669645, 717666, 753817, 754267, 95554 3.4.21.7 milk plasmin is the principal protease in milk 712488 3.4.21.7 monocyte - 688153, 717165 3.4.21.7 additional information ECM 688737 3.4.21.7 additional information high level of plasmin activity in high electrolyte ratio breast cysts, which have a low risk for cancer development 685923 3.4.21.7 additional information in PC-3 cells, processing of pro-brain-derived neurotrophic factor by plasmin occurs in the pericellular environment 686775 3.4.21.7 additional information in PCAEC cells, plasmin induces an endothelium-dependent relaxation and a concentration-dependent transient elevation in the cytosolic Ca2+ concentrations. Plasmin concentration-dependently induces NO production 684784 3.4.21.7 additional information plasmin is abundant in human atherosclerotic lesions, where it colocalizes with dendritic cells 717165 3.4.21.7 additional information tubular epithelial cell 684328 3.4.21.7 neuron - 707135 3.4.21.7 peridontium - 717069 3.4.21.7 plasma - 650728, 685074, 685797, 707847, 718272, 95548, 95553, 95555 3.4.21.7 plasma in blood as zymogen plasminogen 717469 3.4.21.7 pyramidal neuron in CA1 pyramidal neuron, plasmin application potentiates the N-methyl-D-aspartate receptor-dependent component of miniature excitatory postsynaptic currents recorded from CA1 pyramidal neurons but has no effect on -amino-3-hydroxy-5-methyl-4-isoxazole propionate- or -aminobutyric acid receptor-mediated synaptic currents. Plasmin also increased N-methyl-D-aspartate-induced whole cell receptor currents recorded from CA1 pyramidal cells 698776 3.4.21.7 RAW-264.7 cell - 717866 3.4.21.7 serum - 687206, 95548 3.4.21.7 serum plasmin activity and alpha1-antitrypsin activity increase with age with a direct correlation between body mass index and elastase and plasmin activity, and alpha1-antitrypsin concentration. Plasmin and elastase activity and cholesterol concentration inversely correlate with trypsin activity and matrix metalloproteinase-9 concentration 695428 3.4.21.7 skin - 718272 3.4.21.7 skin of the ears 718272 3.4.21.7 tenocyte - 732222 3.4.21.7 urine - 731900 3.4.21.7 uterus steroid-treated ovariectomized mice deficient in tissue inhibitor of metalloprotease-1 and exposed to estrogen show a significant increase in plasmin activity. Increase is probably due to reduced expression of plasmin inhibitors serpinb7 and serpinb2 700313 3.4.21.7 vitreous humor normal eyes have a low, albeit detectable, level of plasmin. Levels of plasmin are higher in eyes from rabbits with proliferative vitreoretinopathy. Amounts correlate with the stage of proliferative vitreoretinopathy 687206 3.4.21.7 vitreous humor vitreous from patients with proliferative vitreoretinopathy have readily detectable levels of plasmin. Presence of plasmin is not unique to patients with proliferative vitreoretinopathy, but also present in a patient undergoing retinal surgery unrelated to proliferative vitreoretinopathy 687206