2.7.4.3 3T3-L1 cell - 722732 2.7.4.3 adipose tissue - 721943 2.7.4.3 adult - 723336 2.7.4.3 bone marrow mononuclear cell - 705850 2.7.4.3 brain - 642558, 642566, 672502, 762326 2.7.4.3 brain expressed exclusively in brain 762326 2.7.4.3 brain moderate expression 722394 2.7.4.3 brain muscle isozyme 642601 2.7.4.3 brain cortex - 705503 2.7.4.3 bronchus - 762326 2.7.4.3 C2C12 cell - 692228 2.7.4.3 egg - 703297, 723336 2.7.4.3 embryo - 703297 2.7.4.3 embryo embryonic cilia 674861 2.7.4.3 embryo isolated embryonic cilia. A 130000 Dalton isoform is responsible for 93% of nonmitochondrial ATP regeneration from ADP in cilia. Presence of at least one additional adenylate kinase isoform 691686 2.7.4.3 endothelium vascular endothelial cells 674609 2.7.4.3 epidermal cell - 721943 2.7.4.3 epidermis - 721943 2.7.4.3 erythrocyte - 642556, 642558, 642563, 642566, 642567, 642603, 762326 2.7.4.3 fibroblast - 705851 2.7.4.3 flagellate - 691686 2.7.4.3 flagellate most of protein is tightly bound to the axoneme 674861 2.7.4.3 fruit - 642558 2.7.4.3 HaEpi cell - 721943 2.7.4.3 heart - 642558, 642566, 642568, 642569, 642572, 642618, 672502, 693007 2.7.4.3 heart isoform AK2 642621 2.7.4.3 heart muscle isozyme 642601 2.7.4.3 HeLa cell - 723742 2.7.4.3 hemocyte - 721943 2.7.4.3 hepatocyte in primary culture 673004 2.7.4.3 hippocampus - 676166 2.7.4.3 hippocampus hippocampal slices, presence of an ecto-adenylate kinase 676166 2.7.4.3 HUVEC cell - 691397 2.7.4.3 inner ear adenylate kinase 2 is specifically expressed in the stria vascularis region of the inner ear 705851 2.7.4.3 kidney - 642558, 642566 2.7.4.3 kidney liver isozyme 642601 2.7.4.3 larva - 721943 2.7.4.3 leaf - 642558, 642591, 642592 2.7.4.3 leaf MeADK1 and MeADK2 in 2-month-old leaves have similar expression patterns under a diurnal light-dark cycle. MeADK2 transcripts are expressed at much higher levels than MeADK1 in 5-month-old leaves and roots 761742 2.7.4.3 lens - 642566 2.7.4.3 leukocyte - 642558 2.7.4.3 liver - 642556, 642558, 642559, 642560, 642565, 642566, 642573, 642601, 642602, 642620, 672502, 673317 2.7.4.3 liver isoform AK2 642621 2.7.4.3 lung - 642558 2.7.4.3 lymph node - 705850 2.7.4.3 lymph node moderate expression 722394 2.7.4.3 mammary gland high expression level 722394 2.7.4.3 metacercaria - 723336 2.7.4.3 midgut - 721943 2.7.4.3 additional information - 642558 2.7.4.3 additional information cell-free synthesis in mRNA-dependent rabbit reticulocyte lysate system 642595 2.7.4.3 additional information high activities in tissues where turnover of energy from adenine nucleotides is great, e. g. muscle 642558 2.7.4.3 additional information present in all tissues tested 672502 2.7.4.3 additional information rabbit and human carry a minimum of 2 sets of isozymes within an individual: one set in muscle, erythrocytes, brain and another in liver, kidney and spleen 642558 2.7.4.3 additional information tissue distribution 642558, 642601 2.7.4.3 muscle - 642556, 642558, 642559, 642560, 642562, 642564, 642565, 642566, 642570, 642571, 642573, 642596, 642598, 642599, 642601, 642606, 642610, 642617, 672502, 673317, 674609, 675108, 701686, 704850 2.7.4.3 muscle breast muscle 642595, 761112 2.7.4.3 muscle isoform AK2, skeletal muscle 642621 2.7.4.3 muscle lateral muscle 761112 2.7.4.3 muscle mantle muscle 642600 2.7.4.3 muscle skeletal muscle 642597 2.7.4.3 myotube expression level of adenylate kinase 1 and ATP synthase beta is strongly increased during myogenesis 692228 2.7.4.3 neuron - 662839 2.7.4.3 oviduct - 672502 2.7.4.3 pancreas - 692004 2.7.4.3 pancreatic islet cytosolic isoforms AK1 and AK5 are expressed in human islets and INS-1 cells. Elevated concentrations of glucose inhibit AK1 expression 690717 2.7.4.3 peripheral blood cell - 705850 2.7.4.3 peripheral blood mononuclear cell - 704723 2.7.4.3 pharynx moderate expression 722394 2.7.4.3 pituitary gland high expression level 722394 2.7.4.3 promastigote - -, 661631 2.7.4.3 retina - 673195, 673317 2.7.4.3 root MeADK2 transcripts are expressed at much higher levels than MeADK1 in 5-month-old leaves and roots 761742 2.7.4.3 root MeADK2 transcripts ise expressed at much higher levels than MeADK1 in 5-month-old leaves and roots 761742 2.7.4.3 seed - 761621 2.7.4.3 serum - 691397 2.7.4.3 skeletal muscle - 762326 2.7.4.3 skeletal muscle in contrast to decreased levels of pyruvate kinase, enolase and phosphofructokinase, the mitochondrial ATP synthase, succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase and adenylate kinase are increased in senescent fibres 695067 2.7.4.3 skin neonatal rats 642558 2.7.4.3 sperm sperm flagellum. 31% of the nonmitochondrial ATP regeneration are due to the 130000 Dalton adenylate kinase isozyme and 69% due to the flagellar creatine kinase 691686 2.7.4.3 sperm flagellum - 674861 2.7.4.3 sperm flagellum expression is upregulated during late spermiogenesis when the flagellum is being assembled 672502 2.7.4.3 sperm flagellum mRNA is present at low but relatively equivalent levels in pachytene spermatocytes, round spermatids, and condensing spermatids 672502 2.7.4.3 spleen - 642558, 642566, 705850 2.7.4.3 spleen moderate expression 722394 2.7.4.3 spore - 642558 2.7.4.3 TBY-2 cell - 672407 2.7.4.3 TBY-2 cell non-photosynthetic cell 672407 2.7.4.3 testis - 672502, 762326 2.7.4.3 testis high expression level 722394 2.7.4.3 thymus high expression level 722394 2.7.4.3 Tobacco Bright Yellow 2 cell - 672407 2.7.4.3 trachea high expression level 722394 2.7.4.3 tuber - 693418 2.7.4.3 uterus moderate expression 722394 2.7.4.3 vitreous humor - 762326