2.3.1.B41 5637 cell - 729849 2.3.1.B41 A-375 cell - 756871 2.3.1.B41 adipose tissue - 755904, 755918 2.3.1.B41 artery - 756672 2.3.1.B41 astrocyte - 756691 2.3.1.B41 BEL-7402 cell - 757530 2.3.1.B41 brain - 729145, 756392 2.3.1.B41 BxPC-3 cell - 756689 2.3.1.B41 C2C12 cell - -, 755766, 758395 2.3.1.B41 carcinoma cell - 756689 2.3.1.B41 cardiac fibroblast - 739733 2.3.1.B41 cardiac muscle fiber - 756879, 756973, 758395 2.3.1.B41 cardiomyocyte - 738170 2.3.1.B41 embryo - 757931 2.3.1.B41 embryoid body - 756879 2.3.1.B41 embryonic fibroblast - 730101 2.3.1.B41 embryonic stem cell - 739132, 756407, 756879 2.3.1.B41 endothelial cell - 756672 2.3.1.B41 endothelium - 756672 2.3.1.B41 G-361 cell - 756871 2.3.1.B41 gastrocnemius - -, 755766 2.3.1.B41 HCCLM-3 cell - 757530 2.3.1.B41 heart - 738170, 756672, 758395 2.3.1.B41 HEK-293 cell - 757236 2.3.1.B41 HeLa cell - 730527, 755787 2.3.1.B41 HEP-3B cell - 757530 2.3.1.B41 Hep-G2 cell - 737977, 756689, 757883 2.3.1.B41 hepatocellular carcinoma cell - 737977 2.3.1.B41 hepatocyte - 757644 2.3.1.B41 hepatoma cell - 757883 2.3.1.B41 hippocampus - 756392 2.3.1.B41 HL-7702 cell - 757530, 757644 2.3.1.B41 HS-294T cell - 756871 2.3.1.B41 Huh-7 cell - 737977, 757883 2.3.1.B41 HUVEC cell - 729362, 756672 2.3.1.B41 kidney - -, 756672, 756689, 756973 2.3.1.B41 liver - 756672, 756689, 757530, 757644, 757883 2.3.1.B41 lung - 756672, 756689 2.3.1.B41 MCF-7 cell - 756689, 757667 2.3.1.B41 MEF cell - 758437 2.3.1.B41 melanocyte - 756871 2.3.1.B41 mesenchymal stem cell - 756407 2.3.1.B41 MHCC-97H cell - 757530 2.3.1.B41 MHCC97-L cell - 757530 2.3.1.B41 muscle fibre - 755766, 758395 2.3.1.B41 myoblast - -, 755766 2.3.1.B41 neural stem cell - 757931 2.3.1.B41 neuron - 756392 2.3.1.B41 ovarian cancer cell - 738169 2.3.1.B41 OVCAR-3 cell - 738169 2.3.1.B41 pancreas - 756689 2.3.1.B41 podocyte - 756973 2.3.1.B41 retinal microvascular endothelial cell - 738283 2.3.1.B41 SH-SY5Y cell - 756392 2.3.1.B41 SK-MEL-2 cell - 756871 2.3.1.B41 SK-MEL-28 cell - 756871 2.3.1.B41 skeletal muscle - -, 755766, 756973, 758395 2.3.1.B41 skin - 729520, 756871 2.3.1.B41 SKOV-3 cell - 738169 2.3.1.B41 soleus - -, 755766 2.3.1.B41 spinal cord - 756691 2.3.1.B41 spleen - 756672, 756689 2.3.1.B41 squamous cell carcinoma cell - 729520 2.3.1.B41 temporal lobe - 756392 2.3.1.B41 THP-1 cell - 757667 2.3.1.B41 UM-UC-3 cell - 729849 2.3.1.B41 umbilical vein endothelial cell - 756672 2.3.1.B41 vascular endothelial cell - 756672 2.3.1.B41 white adipose tissue - 756689 2.3.1.B41 WM-115 cell - 756871 2.3.1.B41 WM-35 cell - 756871 2.3.1.B41 WM-451Lu cell - 756871 2.3.1.B41 podocyte a dramatic reduction in Sirt6 is detected in the podocytes in diabetic mice relative to those in control mice -, 756973 2.3.1.B41 keratinocyte epidermal 729520 2.3.1.B41 lung fetal 757294 2.3.1.B41 hepatoma cell HCC cell, SIRT6 upregulation is quite prevalent in HCC tissues and closely correlated with worse overall survival, disease-relapse free survival, and HCC metastasis 757530 2.3.1.B41 multiple myeloma cell high expression 737930 2.3.1.B41 brain highly expressed in cortical and hippocampal regions and enriched in the synaptosomal membrane fraction 730473 2.3.1.B41 hepatoma cell increased SIRT6 expression in HCC, SIRT6 expression pattern and its association with HCC metastasis, overview 757644 2.3.1.B41 myofibroblast lung, level of SIRT6 in in vitro model of myofibroblast differentiation, overview 757294 2.3.1.B41 embryonic fibroblast MEF cells 755978 2.3.1.B41 additional information most of the melanoma cell lines exhibit significantly higher expression of SIRT6 protein and mRNA as assessed by immunoblot and RT-qPCR analyses, respectively 756871 2.3.1.B41 bladder transitional cell carcinoma cell line muscle invasive urothelial carcinoma of the bladder. Decline of SIRT6 expression when bladder cancer progresses from stage T2 to stage T4 729849 2.3.1.B41 melanoma cell overexpression of SIRT6 in human melanoma tissues 756871 2.3.1.B41 additional information SIRT6 and PP2A regulatory subunit (PPP2AR1A, the main Tau phosphatase) expression are positively correlated in normal brains, but this correlation is lost in Alzheimer's disease brains 756392 2.3.1.B41 additional information Sirt6 expression and Sirt6-wild-type-1 colocalization is suppressed in the glomeruli of patients with diabetic nephropathy (DN) 756973 2.3.1.B41 additional information Sirt6 expression is reduced in the kidney of streptozotocin(STZ)-induced diabetic mice -, 756973 2.3.1.B41 additional information SIRT6 expression levels regulate NAD+ levels in different organs 756689 2.3.1.B41 preadipocyte SIRT6 expression pattern analysis during bovine preadipocyte differentiation, overview 755904 2.3.1.B41 glioma cell SIRT6 is down-regulated in human glioma tissues 729145 2.3.1.B41 brain SIRT6 is highly expressed in human brains but reduced in Alzheimer's disease patients, SIRT6 mRNA and protein levels are reduced in patients with Alzheimer's disease in temporal cortex and hippocampus 756392 2.3.1.B41 retina SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation 730790 2.3.1.B41 additional information SIRT6 promoted HCC metastasis, expression analysis in HCC cell lines, overview. SIRT6 expression is significantly increased. SIRT6 is also upregulated in Hep3B and LO2 cells 757530 2.3.1.B41 skin sun-protected normal skin 729520