1.6.3.5 adipose tissue - 742004 1.6.3.5 adrenal gland - 742004 1.6.3.5 adrenal gland substantial expression cortex of adrenal gland 728281 1.6.3.5 blood - 742961, 743215 1.6.3.5 blood enzyme is secreted into the blood by the kidney 728036 1.6.3.5 blood plasma - 741775, 742454 1.6.3.5 brain - 743215 1.6.3.5 cardiomyocyte - 743188 1.6.3.5 granulosa cell substantial expression in granulosa 728281 1.6.3.5 heart - 741788, 743215 1.6.3.5 heart besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine 728036 1.6.3.5 HEK-293T cell - 743189 1.6.3.5 HK-2 cell proximal renal tubular epithelial cell 764894 1.6.3.5 kidney - 741574, 741788, 741869, 742004, 743215 1.6.3.5 kidney enzyme is secreted into the blood by the kidney. Gene expression is highest in the kidney 728036 1.6.3.5 liver - 741788 1.6.3.5 additional information renalase is predominantly expressed in reproductive/steroidogenic systems, with particularly substantial expression in oocytes, granulosa, interstitial and luteal cells of ovary, spermatogenic cells of testis, and cortex of adrenal gland 728281 1.6.3.5 nerve - 742004 1.6.3.5 oocyte substantial expression in oocytes 728281 1.6.3.5 ovary substantial expression in interstitial and luteal cells of ovary. Expression increases in testes and ovaries as mice develop and is further enhanced in the ovaries of pregnant mice 728281 1.6.3.5 pancreas little to no renalase is detected by histochemistry in the normal pancreatic head in the absence of abdominal trauma. In chronic pancreatitis, renalase immunoreactivity localizes to peri-acinar spindle-shaped cells in some samples 765662 1.6.3.5 skeletal muscle - 741788, 743215 1.6.3.5 skeletal muscle besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine 728036 1.6.3.5 small intestine besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine 728036 1.6.3.5 testis substantial expression spermatogenic cells of testis. Expression increases in testes and ovaries as mice develop 728281 1.6.3.5 urine - 741869, 742454, 742685