1.1.1.22 4T1 cell - 760809 1.1.1.22 6DT1 cell - 760809 1.1.1.22 breast - 762065 1.1.1.22 cartilage - -, 286299, 739967 1.1.1.22 cartilage specimens from the knee joints 739967 1.1.1.22 cell culture - 670630, 740715 1.1.1.22 cell suspension culture - 286302 1.1.1.22 chondrocyte articular -, 739967 1.1.1.22 chondrocyte articular chondrocyte 690024 1.1.1.22 chondrocyte overexpression of c-Krox in articular chondrocytes depresses both UDPGD mRNA steady-state level and protein expression 667414 1.1.1.22 embryo silencing of UGDH decreases glycosaminoglycan synthesis causing severe embryonic malformations because of defective gastrulation process. Overexpression of the enzyme from Xenopus laevis in human smooth muscle cells increases the accumulation of hyaluronan 669522 1.1.1.22 fibroblast primary fivbroblast 761985 1.1.1.22 fibroblast cell line enzyme activity depends on growth phase of the culture 286304 1.1.1.22 flower the abundance of enzyme mRNA in pistils is more than 3fold greater than that in other parts, and the abundance in stamens and calyx tubes is relatively high compared with that in sepals and petals 726483 1.1.1.22 fruit changes in the mRNA level during peach fruit development correspond to changes in the amount of cell wall material and the cell wall uronic acid content. These are greater in the fruits of the commercial cultivars compared with the Japanese native peach cultivars, and the expression of enzyme is higher in the fruits of the commercial cultivars 726483 1.1.1.22 leaf - 667513, 670630, 740128 1.1.1.22 leaf the level of mRNA in immature leaves is much higher than that in mature leaves 726483 1.1.1.22 leaf young leaf 654831 1.1.1.22 liver - 286291, 286295, 286296, 286299, 286300, 286303, 286306, 725729 1.1.1.22 liver high expression level 711665 1.1.1.22 LNCaP cell - 711665 1.1.1.22 MCF-7 cell - 697937 1.1.1.22 MDA-MB-231 cell - 760676, 762065 1.1.1.22 additional information the LgUGDH gene is expressed in all larch plant organs, primarily in the larch stems, in addition to its roots and leaves 740128 1.1.1.22 additional information the organism grows optimally in 1.7-2.5 M NaCl -, 740935 1.1.1.22 additional information the organism grows optimally in 3-5 M NaCl, requiring the higher salinity for proper growth and cell shape -, 740935 1.1.1.22 MVT-1 cell - 760809 1.1.1.22 oocyte - 657189 1.1.1.22 PC-3M-LN4 cell prostate tumor cell line derived from PC-3 cells 711665 1.1.1.22 pollen - 286294 1.1.1.22 prostate high expression level 711665 1.1.1.22 prostate cancer cell - 711665 1.1.1.22 prostate gland increased UGDH expression in cancerous acini and decreased expression in normal-appearing acini of the same prostate relative to acini of non-cancerous prostates 698331 1.1.1.22 root - 700488, 740128 1.1.1.22 root nodule - 286307 1.1.1.22 seedling - 700488 1.1.1.22 skin - 286296 1.1.1.22 small intestine - 286303 1.1.1.22 stem - 654351, 740128 1.1.1.22 stem identification of nine putative UGDH genes, more than 77% of the genes are predominantly expressed in the stem 762397 1.1.1.22 TOV-21G cell - 761588 1.1.1.22 vulva enzyme activity increases dramatically in a special subset of vulval cells during vulval morphogenesis 657189 1.1.1.22 xylem differentiating 654831 1.1.1.22 ZR-75-1 cell siRNA for the human enzyme is put into a pRNA-U6.1/Neo vector and chemically transfected into bresat cancer cells. The UGDH siRNA plasmid then knocks down UGDH expression in ZR-75-1 cells 668055