6.2.1.65 physiological function disruption of the SdgA gene blocks salicylate degradation. Cell extracts from Escherichia coli transformants expressing each of the SdgABCDEFGHR genes show that SdgA, SdgC, ATP, CoA, and NADH are necessary to convert salicylate to gentisate. SdgA requires CoA and ATP as cofactors 755838