4.2.1.174	evolution	diterpene synthases transcriptome analysis of Marrubium vulgare leaves, phylogenetic analysis, overview. CPS1 is a class II diterpene synthase, phylogenetic analysis	743469	
4.2.1.174	metabolism	enzyme CPS1 produces a precursor for marrubiin biosynthesis, pathway overview	743469	
4.2.1.174	additional information	enzyme CPS1 contains a DIDD functional motif	743469	
4.2.1.174	physiological function	in contrast with previously known diterpene synthases that introduce a hydroxyl group at carbon C-8 of the labdane backbone, the MvCPS1-catalyzed reaction proceeds via oxygenation of an intermediate carbocation at C-9, yielding the bicyclic peregrinol diphosphate. A labdane-type diterpene structure bearing an oxygen functionality at carbon C-9 is characteristic for marrubiin and many of the specialized diterpenoids in the genus Marrubium. Enzyme CPS1 produces a precursor for marrubiin biosynthesis	743469