4.2.1.10 evolution There are two distinct dehydroquinases, designated as type I DHQ1, and type II DHQ2, which have different biochemical and biophysical properties and exhibit little sequence similarity. Both subtypes catalyze the same overall reaction through independent mechanisms and with opposite stereochemistry. Type I DHQ occurs in Escherichia coli and Salmonella typhimurium, type II DHQ in Mycobacterium tuberculosis, Streptomyces coelicolor and Helicobacter pylori 714749 4.2.1.10 metabolism dehydroquinase catalyzes the third step in the shikimate pathway, the reversible dehydration of 3-dehydroquinate to 3-dehydroshikimate 714751 4.2.1.10 metabolism dehydroquinase is the third enzyme in the shikimic acid pathway and catalyzes the reversible dehydration of 3-dehydroquinic acid to form 3-dehydroshikimic acid 714749 4.2.1.10 metabolism the enzyme is the third enzyme of the shikimate pathway, which is essential in Mycobacterium tuberculosis -, 714105