4.1.1.6	evolution	the enzyme belongs to the MmgE/PrpD family	-, 727576	
4.1.1.6	metabolism	in the first steps of the citric acid cycle, citrate and cis-aconitate are formed, the enzymes preceding in the pathway, namely citrate synthase and aconitase, are found in the mitochondria. In the last step, the only itaconic acid pathway dedicated step, cis-aconitate decarboxylase (CadA) forms itaconic acid releasing carbon dioxide in the cytosol	-, 727576