3.6.1.29	malfunction	a loss of FHIT expression associated with poor prognosis and beta-catenin expression	718972	
3.6.1.29	physiological function	formation of Fhit-substrate complex results in an apoptosis initiation signal while subsequent hydrolysis of ApnA terminates this action	719088	
3.6.1.29	physiological function	the FHIT protein is a tumor suppressor. FHIT/ferrodoxin reductase complex generates reactive oxygen species and increases calcium uptake into the mitochondria to potentiate the effects of apoptotic agents	718972