2.7.7.9	drug target	since the eukaryotic UDP-glucose pyrophosphorylases are completely unrelated to their prokaryotic counterparts, it is propose that the GalU enzyme is a critical target to fight the pneumococcal disease. Inactivation of the galU gene completely abolishes the formation of the capsule, and, therefore, renders the pneumococcus completely avirulent. The proposed colorimetric test is as appropriate to screen and characterize specific inhibitors of GalU enzyme in the search of antipneumococcal drugs	761608	
2.7.7.9	drug target	UDP-mediated decrease in the virulence of Streptococcus pneumoniae. UDP is an effective inhibitor of pneumococcal UGPase	760971	
2.7.7.9	evolution	a feature that discriminates UGPs of different species is the quaternary organization. While UGPs in protists are monomers, di- and tetrameric forms exist in bacteria, and the enzyme from yeast and human are octameric UGPs	722370	
2.7.7.9	evolution	the plant UGPases belongs to the so called UGPase-A family	723370	
2.7.7.9	malfunction	in comparison with wild-type strain V07DF2 and complementation strains, the UGP knocked down mutant 24C9 exhibits sensitivity to sodium dodecyl sulfate (perturbing membrane integrity) and high sodium chloride concentration (high osmotic pressure stress). More than 25% of the conidia of the mutant developed into short and swollen hypha and formed hyperbranching and compact colonies. The mutant exhibits decreased virulence on cotton and tobacco seedlings. The germination of the mutant spores is significantly delayed compared with the wild-type strain on the host roots	-, 761188	
2.7.7.9	malfunction	knockdown of rml-1, rml-4 and rml-5 (but not rml-2 and rml-3) causes lethality of the embryo	747027	
2.7.7.9	malfunction	lack of sulfoquinovosyldiacylglycerol in the Arabidopsis ugp3 knockout mutant. The mutant does not show significant differences in glycosides and saccharides between wild type and ugp3 mutants	723680	
2.7.7.9	metabolism	essential enzyme involved in carbohydrate metabolism	-, 761188	
2.7.7.9	metabolism	in sugarcane, UDP-glucose (the product of the reaction) is a branch-point in the carbon channelling into other carbohydrates, such as sucrose and cellulose, which are the major factors for sugarcane productivity	762236	
2.7.7.9	metabolism	involved in cell envelope precursor synthesis	-, 706591