2.7.2.2	metabolism	carbamate kinase catalyzes the last step of the essential L-arginine pathway, converting ADP and carbamoyl phosphate to ATP and ammonium carbamate	739466	
2.7.2.2	metabolism	carbamoyl-phosphate synthetase and ornithine carbamoyltransferase form an efficient channeling cluster for carbamoyl phosphate, an extremely thermolabile and potentially toxic metabolic intermediate. Therefore, by physically interacting with each other, carbamoyl-phosphate synthetase and ornithine carbamoyltransferase prevent the thermodenaturation of carbamoyl phosphate in the aqueous cytoplasmic environment	745268	
2.7.2.2	metabolism	the enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP and carbamoyl phosphate to ATP and carbamate	738607	
2.7.2.2	metabolism	the enzyme is part of the the arginine deiminase system, overview	735216	
2.7.2.2	additional information	mdelling of the environment of Cys242 superposed in three conformational states, the AMP-PNP bound structure, the citric acid bound structure, and the thiocarbamoylated structure, overview. Modification of Cys242 interferes with the conformational transition that accompanies nucleotide binding, whereas the citric acid binding remains unaltered and the auxiliary domain is in the closed conformation	738607	
2.7.2.2	physiological function	carbamate kinase is an essential Giardia lamblia enzyme	738607	
2.7.2.2	physiological function	physically interacting with each other, carbamate kinase and ornithine carbamoyltransferase prevent thermodenaturation of carbamoyl phosphate (a precursor of pyrimidines and arginine, which is an extremely labile and potentially toxic intermediate) in the aqueous cytoplasmic environment. The carbamoyl phosphate channelling complex involves carbamate kinase, ornithine carbamoyltransferase and aspartate carbamoyltransferase	-, 721560