2.3.1.294	malfunction	an inactive enzyme-deficient mutant has less density of mycolic acid, embedded in periplasmic space, with normal thickness in the cell envelope, which results in loss of acid-fastness	-, 755625	
2.3.1.294	malfunction	enzyme gene deletion in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. An additional outcome of enzyme gene deletion is the loss of ketomycolic acid trans-cyclopropanation and a drastic reduction in methoxymycolic acid trans-cyclopropanation. Although deletion of the enzyme also markedly alters the colony morphology and abolishes classic serpentine growth (cording), the most profound effect of enzyme gene deletion is the ability of the mutant strain to persist in infected immunocompetent mice for up to 600 days without causing disease or mortality	755237	
2.3.1.294	malfunction	enzyme mutants exhibit strikingly altered cell wall permeability, leading to a marked increase in susceptibility to lipophilic antibiotics and the host antimicrobial molecules defensing and lysozyme. The predominant chain lengths are 2-4 carbons shorter for oxygenated mycolates in the absence of the enzyme	-, 754769	
2.3.1.294	metabolism	the enzyme can catalyze both saturated and unsaturated fatty acid biosynthesis	752750	
2.3.1.294	metabolism	the enzyme is involved in fatty acid and mycolic acid biosynthesis	-, 754056	
2.3.1.294	metabolism	when enzyme KasB is coexpressed with KasA, it appears to be capable of facilitating the production of lipids of the length of full meromycolic acids. KasB therefore may accept primers directly from KasA that average 40 carbons in length. KasA and KasB thus function in tandem to carrier out acyl chain elongation to achieve meromycolic acid synthesis from acyl primers provided by type I fatty acid synthase system	-, 755623	
2.3.1.294	physiological function	enzyme-dependent mycolate elongation is essential for cording and cell wall impermeability. Enzyme-dependent cell wall impermeability is essential for antibiotic resistance. The enzyme is essential for resistance to macrophage antimicrobial activity	-, 754769	
2.3.1.294	physiological function	the enzyme is involved in cording and acid-fast staining and is required for survival and virulence in infected mice	-, 754770