2.1.3.1 metabolism the enzyme is one of three biotin-dependent carboxylases in the dicarboxylic acid pathway controlling the carbon fluxin the Wood-Werkman cycle, metabolic flux analysis -, 737181 2.1.3.1 metabolism the enzyme provides an alternative pathway for malonyl-CoA synthesis and increases fatty acid production. The enzyme efficiently directs tricarboxylic acid cycle intermediates towards fatty acid synthesis during the acetyl-CoA carboxylation bypass -, 756213 2.1.3.1 physiological function the enzyme is involved in production of anticancer ansamitocin P-3, AP-3 by submerged cultures of Actinosynnema pretiosum in medium containing agro-industrial residues. The production is increased by addition of metal ions, especially Mg2+ -, 719105