1.7.1.B3	evolution	analysis of evolutionary or molecular mechanism of divergence of the nitroreductase/flavin reductase family, overview. The enzyme is similar to NfsA from Escherichia coli, overview	-, 742109	
1.7.1.B3	evolution	nitroreductases are a family of flavoproteins that catalyze the NAD(P)H-dependent reduction of nitro groups to hydroxylamino and/or amino groups on various nitro-substituted compounds	743709	
1.7.1.B3	additional information	comparisons of the quantitative structure-activity relationships of single-electron reduction of quinones and nitroaromatic compounds by dehydrogenase (electron transferase) flavoenzymes, overview	741786	
1.7.1.B3	additional information	the enzyme crystal structure of NfsA, PDB ID 1F5V, is used for molecular ligand docking studies	743709	
1.7.1.B3	physiological function	enzyme is a flavoprotein with NADPH-dependent quinone reductase and nitroreductase activities	-, 765499	
1.7.1.B3	physiological function	NfsA has potential applications in the biodegradation of nitroaromatic environment pollutants, e.g. explosives, and is also of interest for the anticancer strategy gene-directed enzyme prodrug therapy	741786	
1.7.1.B3	physiological function	residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA, Phe42 is important for maintaining NfsA activity and structure	742167