1.3.1.34	malfunction	the gene disruption of fadH, which 2,4-dienoyl-CoA reductase, impairs production of eicosapentaenoic acid under docosahexaenoic acid-supplemented conditions, and the estimated conversion rate decreases by 86% compared to that of the parent strain	-, 763076	
1.3.1.34	physiological function	DECR is the major reductase involved in polyunsaturated fatty acid beta-oxidation. DECR is related to bacterial reductases. A DECR null mutant is unable to catabolize unsaturated fatty acids and accumulates the intermediate 2,4-decadienoyl-CoA. The mutant is unable to survive in macrophages and is avirulent in BALB/c mice	759709