1.2.1.36	evolution	aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of the aldehyde dehydrogenase superfamily that oxidizes aldehydes to their corresponding acids, reactions that are coupled to the reduction of NAD+ to NADH	763529	
1.2.1.36	evolution	the enzyme is a member of the ALDH1 protein family	743375	
1.2.1.36	malfunction	ablation of retinoic acid signaling in host dencritic cells by deletion of isoform RALDH2 protects mice from acute graft-versus-host disease. Isoform RALDH1 deletion fails to reduce acute graft-versus-host disease	763337	
1.2.1.36	malfunction	acute inflammation rapidly downregulates ALDH1A1 expression in whole liver while increasing its expression in periportal macrophages	743375	
1.2.1.36	malfunction	H-1299 cells expressing C302A, E107G, and I304K mutant forms of ALDH1A1 lacked aldehyde-dehydrogenase activity	763529	
1.2.1.36	metabolism	ALDH1A1 and ALDH3A1 have the same GSH/DHLA-dependent NAD+-reduction activity	763529	
1.2.1.36	metabolism	both isoforms Raldh1 and -2 contribute to atRA biosynthesis in hippocampus astrocytes	725461	
1.2.1.36	metabolism	retinaldehyde dehydrogenase 1 induction impairs glucose metabolism partly via modulating phosphoenolpyruvate carboxykinase 1 and glucokinase expressions	762688	
1.2.1.36	metabolism	the enzyme plays a role in the physiological metabolism of apocarotenoids	763752	
1.2.1.36	additional information	enzyme structure comparisons, overview	763136