1.14.20.4 malfunction an insertion in the PgLDOX gene (leucoanthocyanidin dioxygenase/anthocyanidin synthase) is responsible for the white anthocyanin-less phenotype. None of the analyzed white pomegranate tissues are able to synthesize mRNA corresponding to the PgLDOX gene 743595 1.14.20.4 malfunction lack of enzyme encoding gene BjANS expression blocks biosynthesis of proanthocyanidins in the yellow seed coat, and therefore seeds appear yellow because of transparent testa 725953 1.14.20.4 malfunction two inactive alleles are reported: a mutant anthocyanidin synthase allele containing a 4-bp insertion at the end of exon1 is identified from yellow bulbs of the F2 population in which the DFR-A (dihydroflavonol 4-reductase) genotype is homozygous for an active allele. The 4-bp insertion causes a frame-shift mutation and results in creation of a premature stop codon at the start of exon2. This mutant anthocyanidin synthase allele is designated ANSPS allele. RT-PCR results show that transcripts of the ANSPS allele are almost undetectable in yellow F2 bulbs, implying the involvement of nonsense-mediated mRNA decay. Another inactive anthocyanidin synthase allele is identified from the light-red F1 populations showing complementation between DFR-A (dihydroflavonol 4-reductase) and anthocyanidin synthase genes. A critical amino acid change of the strictly conserved serine residue into leucine is found in this mutant allele designated ANSS188L 742427 1.14.20.4 metabolism anthocyanidin synthase is one of the key enzymes in the biosynthesis of both anthocyanins and proanthocyanidins in grapevine -, 713486 1.14.20.4 metabolism anthocyanidin synthase is the key enzyme in anthocyanin biosynthesis 743789 1.14.20.4 metabolism anthocyanidin synthase, a 2-oxoglutarate iron-dependent oxygenase, converts leucoanthocyanidins into 3-hydroxyanthocyanidin in late flavonoid biosynthesis 725953 1.14.20.4 metabolism key enzyme in biosynthesis of anthocyanins 742599 1.14.20.4 metabolism part of flavonoid biosynthetic pathway 701213 1.14.20.4 metabolism Reaumuria trigyna leucoanthocyanidin dioxygenase is one of three dioxygenases in the flavonoid pathway that catalyzes the formation of anthocyanidins from leucoanthocyanidins. It is involved in enhancing plant response to NaCl stress 743507 1.14.20.4 metabolism the enzyme catalyzes the conversion of colorless leucoanthocyanins into colored anthocyanins 741645