1.1.1.38	malfunction	enzyme inactivation improves the anaerobic production of four-carbon dicarboxylic acids by recombinant Escherichia coli strains expressing oxaloacetate-forming pyruvate carboxylase	760378	
1.1.1.38	malfunction	knockdown of isoform Me2 markedly reduces the glycolytic flux and impairs osteoblast proliferation and differentiation	760840	
1.1.1.38	malfunction	knockdown of ME2 does not inhibit insulin release stimulated by glucose, pyruvate or 2-aminobicyclo [2,2,1]heptane-2-carboxylic acid-plus-glutamine	741010	
1.1.1.38	metabolism	isoform Me2 funnels glucose carbons into malate-aspartate shuttle to sustain glycolysis	760840	
1.1.1.38	additional information	the molecular basis for the different allosteric properties and quaternary structural stability of m-NAD(P)-ME, EC 1.1.1.38 and c-NADP-ME, EC 1.1.1.40. The structural features near the fumarate binding site and the dimer interface are highly related to the quaternary structural stability of c-NADP-ME and m-NAD(P)-ME. Lys57 plays functional roles in both the allosteric regulation and the subunit-subunit interaction of humanm-NAD(P)-ME	737754	
1.1.1.38	physiological function	the mitochondrial malic enzyme isoform Me2 functionally couples the mitochondria with aerobic glycolysis in osteoblasts	760840