5.4.99.33	evolution	SgCbQ clusters with the other three functionally characterized cucurbitadienol synthases and forms a new subfamily that lies between the branches of cycloartenol synthase and lanosterol synthase, non-rooted phylogenetic tree analysis, overview	746038	
5.4.99.33	metabolism	cucurbitadienol synthase and a multifunctional P450, CYP87D18, are involved in biosynthesis of mogrosides in Siraitia grosvenorii. Cucurbitadienol synthase synthesizes cucurbitadienol, that is oxidized by CYP87D18 (EC 1.14.14.71) at C-11 to produce 11-oxo cucurbitadienol and 11-hydroxy cucurbitadienol. Proposed biosynthetic pathway of mogrosides, overview	746042	
5.4.99.33	metabolism	cucurbitadienol synthase and triterpene glycosyltransferase are involved in biosynthesis of mogrosides in Siraitia grosvenorii. Mogrosides, the major bioactive components isolated from the fruits of Siraitia grosvenorii, are a family of cucurbitane-type tetracyclic triterpenoid saponins that are used worldwide as high-potency sweeteners and possess a variety of notable pharmacological activities. Mogrosides are synthesized from 2,3-oxidosqualene via a series of reactions catalyzed by cucurbitadienol synthase (CbQ), Cyt P450s (P450s), and UDP glycosyltransferases (UGTs) in vivo, proposed biosynthetic pathway of mogrosides, overview	746038	
5.4.99.33	metabolism	cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis	716949	
5.4.99.33	physiological function	cyclization of 2,3-oxidosqualene to cucurbitadienol catalyzed by cucurbitadienol synthase SgCbQ in the biosynthesis of mogrosides, the major bioactive components isolated from the fruits of Siraitia grosvenorii. Mogrosides are a family of cucurbitane-type tetracyclic triterpenoid saponins that are used worldwide as high-potency sweeteners and possess a variety of notable pharmacological activities	746042