5.1.99.1 physiological function second step in the pathway responsible for the degradation of branched amino acids and odd chain fatty acids, MMCE participated in autotrophic CO2 fixation via the 3-hydroxypropionate pathway, in propionate fermentation, the regeneration of glyoxylate and in the biosynthesis of polyketide antibiotics 706660 5.1.99.1 physiological function methylmalonyl-CoA epimerase and methylmalonyl-CoA mutase are responsible for producing succinyl-CoA from (S)-methylmalonyl-CoA. Succinyl-CoA is an intermediate connecting the 3-hydroxypropionate/4-hydroxybutyrate cycle and general carbon metabolism. Methylmalonyl-CoA epimerase and methylmalonyl-CoA mutase may also be involved in degradation of propionate and branched-chain amino acids (valine, isoleucine, methionine). The enzyme has a role in CO2 fixation -, 726729 5.1.99.1 physiological function the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway -, 726729 5.1.99.1 physiological function in Escherichia coli, production of propionic acid through the sbm operon requires the activity of a methylmalonyl-CoA epimerase. Expression of MCE finally leads to production of propionic acid from glucose -, 748590