4.3.1.B2	metabolism	key metabolic enzyme,which links amino acid and nucleottide biosynthesis. It uses the substrates glutamine and N'-[(5-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide-ribonucleotide to catalyze the closure of the imidazole ring within histidine biosynthesis and additionally provides 5-aminoimidazole-4-carboxamide ribotide for use in the de novo synthesis of purines	-, 728807	
4.3.1.B2	metabolism	the enzyme catalyzes the fifth step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis	-, 727791	
4.3.1.B2	metabolism	the enzyme links histidine and de novo purine biosynthesis	-, 748148	
4.3.1.B2	physiological function	the enzyme represents a junction between histidine biosynthesis and de novo purine biosynthesis	728731