4.1.3.16 malfunction enzyme deficiency leads to primary hyperoxaluria type 3 728378 4.1.3.16 malfunction enzyme mutations ultimately lead to oxalate accumulation and stone formation in primary hyperoxaluria type 3 747772 4.1.3.16 malfunction mutations are responsible for primary hyperoxaluria type III 713711 4.1.3.16 malfunction primary hyperoxaluria type 3 is due to mutations in the 4-hydroxy-2-oxoglutarate aldolase gene 748294