3.5.3.11 malfunction in vivo knockdown of translation of both ODC1 and AGMAT RNAs resulted in over-expression of genes related to synthesis and transport of polyamines in ovine conceptuses during the peri-implantation period of pregnancy 752459 3.5.3.11 malfunction the role in the agmatinase-like protein (AGM-1) in the alternative pathway to produce polyamines is not its main function since only a slight reduction of polyamines concentration is detected in the DELTAagm-1 het strain. The null mutant DELTAagm-1 (homokaryon strain) is unable to grow and the deficiency of agm-1 in the heterokaryon strain provokes a decrease in elongation rate, conidia and biomass production, despite of having constitutive pathway via the ornithine decarboxylase. Mature hyphae of the DELTAagm-1 het strain presented unusual apical branching and a disorganized Spitzenkörper 753719 3.5.3.11 metabolism the gene agmatine ureohydrolase is involved in polyamine biosynthesis 712287 3.5.3.11 metabolism the role in the agmatinase-like protein (AGM-1) in the alternative pathway to produce polyamines is not its main function since only a slight reduction of polyamines concentration is detected in the DELTAagm-1 het strain. In Neurospora crassa AGM-1 has a close association with the F-actin population via its substrate agmatine, playing an essential role during cell development 753719 3.5.3.11 metabolism utilization of L-arginine in Stichopus japonicus is conducted by three enzymes: nitric oxide synthase, arginase and agmatinase. Balance of the production of these three enzymes is regulated by multiple transcription factors, such as CREB, NF-kappaB/Rel and STAT5, as well as their substrate L-arginine. Stimulation of pathogen LPS disrupts this balance and subsequently influences the immune response conducted by NO 753376 3.5.3.11 physiological function agmatinase-like protein plays a role in the regulation of intracellular concentrations of the neurotransmitter/neuromodulator agmatine 712119 3.5.3.11 physiological function the gene is essential, its deletion failed even in the presence of 1 mM putrescine -, 737576