3.4.21.B26	evolution	the enzyme belongs to the Ca2+-dependent proprotein convertase family of enzymes	731899	
3.4.21.B26	evolution	the enzyme is a serine protease of the proprotein convertase family	732515	
3.4.21.B26	malfunction	complete knockout of PC5/6 is lethal between E4.5-7.5	718009	
3.4.21.B26	malfunction	enzyme-knockout endometrial epithelial cells show reduced capacity to attach to trophoblast spheroids and bind to fibronectin compared with control. Knockdown of the enzyme decreases cell surface presentation of functional integrins-alpha1, alpha2, alpha5, alphaV and alphaVbeta5	731899	
3.4.21.B26	malfunction	gene inactivation of PC5/6 leads to lethality at birth, the lack of PC5/6 in enterocytes results in a significantly higher tumor number in the duodenum, the absence of PC5/6 is also associated with a premature mortality of ApcMin/+ mice that harbor a heterozygote multiple intestinal neoplasia mutation in the adenomatous polyposis coli gene	709911	
3.4.21.B26	malfunction	PC5/6-knockout mouse embryos show developmental abnormalities, and reduced overall mineralization	753112	
3.4.21.B26	malfunction	PC6 knockdown reduces removal of alpha-dystroglycan N-terminus from endometrial epithelial cell surface and blastocyst adhesion	753529	
3.4.21.B26	malfunction	specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases BMP-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers	752449	
3.4.21.B26	malfunction	specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases bone morphogenetic protein-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers. Enzyme inhibition by decanoyl-Arg-Val-Lys-Arg-chloromethylketone and bone morphogenetic protein receptor inhibition by LDN-193189 suppress squamous differentiation, promote mucociliary differentiation, and down-regulate the BMP-2/Smad1/5/8/p38 signaling pathways	731111	
3.4.21.B26	metabolism	the enzyme in the human endometrium is tightly regulated during receptivity for embryo implantation	731899