2.6.1.19	additional information	active site structure analysis, the epsilon-amino group of Lys288, the catalytic residue of CgGABA-AT, may form an internal aldimine with the aldehydic carbon of PLP, which is required for catalysis	-, 758736	
2.6.1.19	physiological function	Arabidopsis thaliana GABA-T functionally complements a Saccharomyces cerevisiae Uga1 mutant lacking GABA transaminase activity, despite mitochondrial localization of the Arabidopsis thaliana enzyme and cytosolic localization of the yeast enzyme. Recombinant GABA-T rescues mutant yeast's GABA growth defect, thermosensitivity and limiting production of reactive oxygen species, but GABA-T is about half as efficient in doing so Saccharomyces cerevisiae Uga1 gene product	739761	
2.6.1.19	additional information	bioinformatic analysis of lncRNAs correlated to enzyme ABAT	759881	
2.6.1.19	malfunction	constitutive overexpression lines of GABA-T are generated in Arabidopsis. Brief cold treatments increases leaf GABA concentrations in both the WT and transgenic line OX1, but the concentrations in OX1 is consistently lower. These findings confirm that GABA-T limits the catabolism of GABA when its production is stimulated by stress, and suggest a bioengineering strategy for improving the availability of succinate semialdehyde for the Krebs cycle or GLYR1, a potential redox-modulating reaction during stress	721953	
2.6.1.19	malfunction	deletion of the gabT gene encoding GABA-T cannot prevent GABA from decomposing at neutral pH. An additional transaminase gene, NCgl2515, is deleted in a gabT-deleted GAD strain, but the GABA concentration in this gabT NCgl2515-deleted GAD strain remains unaltered when pH is maintained at pH 7.5-7.8, demonstrating that GABA decomposition is reduced	-, 760076	
2.6.1.19	malfunction	deletion of the gabT gene encoding GABA-T cannot prevent GABA from decomposing at neutral pH. An additional transaminase gene, NCgl2515, is deleted in a gabT-deleted GAD strain, but the GABA concentration in this gabT-deleted GAD strain NCgl2515 remains unaltered when pH is maintained at pH 7.5-8.0, demonstrating that GABA decomposition is reduced	-, 760076	
2.6.1.19	evolution	EctB-type proteins are highly conserved	-, 759234	
2.6.1.19	evolution	enzyme Atu3300 is predicted by Pfam to include an Aminotrans_3 (aminotransferase class-III) domain, which is characteristic of aminotransferases	-, 760153	
2.6.1.19	metabolism	GABA metabolism	698627	
2.6.1.19	metabolism	GABA transaminase (GABAT) is the key catabolic enzyme of GABA metabolism	-, 759852